【摘要】 目的 探討女性類風濕關節炎（rheumatoid arthritis，RA）患者性激素的變化及其與炎癥指標的關系。 方法 2008年1月-2009年12月檢測RA組45例女性患者（絕經期組16例、黃體期組14例和濾泡期組15例）和正常對照組40例女性（絕經期組14例、黃體期組、濾泡期組各13例）血清性激素水平，同時檢測RA組血沉（SR）、C反應蛋白（CRP）、類風濕因子（RF）、抗環瓜氨酸肽（抗CCP） 抗體的水平。 結果 RA患者絕經期雌二醇（E2）濃度明顯高于正常對照組（P lt;0.05）；RA組黃體期泌乳素（PRL）的濃度明顯高于正常對照組（P lt;0.05）；RA組孕酮（PROG）濃度明顯低于正常對照組（P lt;0.05）；RA組濾泡期PRL明顯高于正常對照組（P lt;0.05）。RA組黃體期PRL與其孕酮（PROG）呈正相關（r=0.754，P=0.031），絕經期E2，黃體期PRL和PROG以及濾泡期PRL與SR、CRP、RF、抗CCP無相關性（P gt;0.05）。 結論 女性RA患者月經周期的不同階段，性激素水平的改變不同，絕經期以雌激素升高明顯，黃體期和濾泡期則以孕激素改變明顯。黃體期PRL與其PROG呈正相關；女性RA患者性激素的變化與其炎癥指標無相關性。
【Abstract】 Objective To explore the change of sex hormone levels in female patients with rheumatoid arthritis (RA) and its relationship with inflammatory markers. Methods The serum sex hormones of 45 female patients with RA (RA group, including menopausal group of 16 patients, luteal phase group of 14 patients and follicular phase group of 15 patients) and 40 females (control group: including menopausal group of 14 females, luteal phase group of 13 females and follicular phase group of 13 females) in the control group between January 2008 and December 2009 were detected. The inflammatory makers of erythrocyte sedimentation rate (SR), C-reactive protein (CRP), rheumatoid factor (RF), and anti-cyclic citrullinated peptide antibodies (anti-CCP) of patients in the RA group were also detected. Results The menopausal estradiol (E2) level and the concentration of prolactin (PRL) of patients with RA were significantly higher than that of patients in the normal control group (P lt;0.05), while the progesterone (PROG) level was significantly lower than that of patients in the control group (P lt;0.05). The PRL level of follicular phase group was significantly higher than that of the normal control group (P lt;0.05). PRL level in the luteal phase was positively correlated with its PROG level (r=0.754, P=0.031). The menopausal E2, the luteal PRL and PROG as well as the follicular phase PRL had no correlation with SR, C-reactive protein, RF, or anti-CCP antibodies (P gt;0.05). Conclusions At different stages of the menstrual cycle in women with RA, the changes of sex hormone levels were different. The concentration of estrogen has increased significantly in menopause, while the progesterone has changed markedly in luteal and follicular phases. PRL in luteal phase is positively correlated with PROG. The changes of sex hormones in female patients with RA show no correlation with inflammatory markers.
引用本文： 劉德芳,郭明陽,劉太華,贠明東,郭玲林. 女性類風濕關節炎患者性激素變化及與炎癥指標關系的研究. 華西醫學, 2011, 26(3): 341-343. doi: 復制