【摘要】 目的 探討成都市成華區中老年人群血脂水平、分布特點及其與胰島素抵抗指數（HOMA-IR）的關系。 方法 2007年5月在此區中老年（50~79歲）人群中隨機抽取672人進行心血管危險因素研究調查，對其血脂水平及HOMA-IR進行統計分析。 結果 人群當中①女性各血脂項目的水平均比男性高，其中總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）的差異有統計學意義（P lt;0.05）；②三酰甘油（TG）升高的比例較高，其中男性為30.0%，女性為27.6%；大部分人群HDL-C、低密度脂蛋白膽固醇（LDL-C）水平處于合適范圍，HDL-C降低的比例為6.0%，LDL-C升高的比例為7.3%；③隨著TG水平的升高、HDL-C 水平的降低，HOMA-IR呈升高趨勢；LDL-C水平的升高，HOMA-IR呈升高趨勢，僅在女性人群中差異有統計學意義（P lt;0.05），在男性人群中差異無統計學意義；④TG與HOMA-IR呈正相關，相關系數為0.185（P=0.000）；HDL-C與HOMA-IR呈負相關，相關系數為-0.145（P=0.000）。LDL-C與HOMA-IR呈正相關，相關系數為0.099（P=0.010）。 結論 TG增高是成都市成華區中老年人群的顯著特點，女性HDL-C比男性高；血脂紊亂與胰島素抵抗相關。
【Abstract】 Objective To investigate the relationship between blood lipids level and homeostasis model assessment-insulin resistance (HOMA-IR) in elder people in Chengdu. Methods In May 2007, 672 people aged from 50 to 79 years in Chengdu were recruited by random sampling methods for the survey of cardiovascular risk factors. The blood lipids level and HOMA-IR were statistically analyzed. Results ① The serum total cholesterol (TC) and high density lipoprotein chole sterol (HDL-C) were obviously higher in women than those in men (P lt;0.05). ② Triacylglycerol (TG) increased in 30.0% of men and 27.6% of women; HDL-C and low density lipoprotein cholesterin (LDL-C) in most of the involved people were appropriate. ③ HOMA-IR increased as the TG level increased and HDL-C decreased; HOMA-IR increased as the LDL-C level increased, which was significant in the females (P lt;0.05). ④ HDL-C was positively correlated with HOMA-IR (r=-0.145, P=0.000); LDL-C was positively correlated with HOMA-IR (r=0.099, P=0.010). Conclusion The increase of hypertriglyceridemia was the most frequent type of the dislipidemia in the elder people in Chengdu; HDL-C level is higher in women than in men. Dyslipidemia is correlated with insulin resistance.
引用本文： 陳小妮,陳曉平,吳凱,王斯,李龍心,萬里艷. 成都市成華區中老年人群血脂水平及其與胰島素抵抗指數的關系. 華西醫學, 2011, 26(3): 328-330. doi: 復制