糖尿病患者神經損害及其危險因素分析_West China Medical Journal

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楊明正 , 徐大雄

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Keywords：

糖尿病; 神經損害; 因素分析

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【摘要】　目的　總結糖尿病（diabetes mellitus，DM）患者神經損害特點及危險因素。　方法　將2009年7月-2010年7月收治的300例DM患者按有無合并糖尿病神經病變（diabetic neuropathy，DN）分為研究組和對照組各150例，進行空腹血糖水平測定，并對每位患者體重指數、血脂水平、吸煙史、血壓水平、DM病程、神經病變家族史進行統計；對疑似有相關病變的DN患者進行脛神經的感覺及運動神經傳導速度測定。　結果　 DM患者伴有體重指數、血脂水平、吸煙、血壓、神經病變家族史異常者更易患DN。DN患者神經損害程度與患者血糖水平及DM病程呈正相關。　結論　血糖越高，病程越長神經損傷越重，肥胖、高血脂、吸煙、高血壓、有神經病變家族史是DN發生的危險因素。

Citation： 楊明正,徐大雄. 糖尿病患者神經損害及其危險因素分析. West China Medical Journal, 2011, 26(2): 242-243. doi: Copy

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2.	Bruce SG, Young TK. Prevalence and risk factors for neuropathy in a Canadian First Nation community[J]. Diabetes Care, 2008, 31(9): 1837-1841.
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6.	Feng Y, Schlosser FJ, Sumpio BE. The Semmes Wein-stein monofilament examination as a screening tool for diabetic peripheral neuropathy[J]. J Vasc Surg, 2009, 50(3): 675-682.
7.	Dros J, Wewerinke A, Bindels P J, et al. Accuracy of monofilament testing to diagnose peripheral neuropathy: asystematic review[J]. Ann Faro Med, 2009, 7(6): 555-558.
8.	Wooten K. Clinical features and electrodiagnosis of diabet-ic peripheral neuropathy in the dysvascular patient[J]. Phys Med Rehabil Clin N Am, 2009, 20(4): 657-676.
9.	Hyllienmark L, Jonsson B, Ekberg K, et al. Abnormal cold perception in the lower limbs: a sensitive indicator for detection of polyneuropathy in patients with type 1 diabetes mellitus[J]. Diabetes Res Clin Pract, 2009, 85(3): 298-303.
10.	Sommer C. Skin biopsy as a diagnostic tool[J]. Curr Opin Neurol, 2008, 21(5): 563-568.
11.	薛瑩, 劉超. 糖尿病神經病變發病機制的研究進展[J]. 醫學綜述, 2007, 13(10): 761.
12.	馬蓮茹. 糖尿病神經病變的認識和評估方法[J]. 山西醫藥雜志, 2010, 39(4): 324.

1. 　Hsu WC, Yen AM, Liou HH, et al. Prevalence and risk factors of somatic and autonomic neuropathy in predia-betic and diabetic patients[J]. Neuroepidemiology, 2009, 33(4): 344-349.
2. 　Bruce SG, Young TK. Prevalence and risk factors for neuropathy in a Canadian First Nation community[J]. Diabetes Care, 2008, 31(9): 1837-1841.
3. 　Pradeepa R, Rema M, Vignesh J, et al. Prevalence and risk factors for diabetic neuropathy in an urban south Indian pop-ulation: the Chennai Urban Rural Epidemiology Study (CURES-55)[J]. Diabet Med, 2008, 25(4): 407-412.
4. 　Tres GS, Lisboa HR, Syllos R, et al. Prevalence and characteristics of diabetic po1yneuropathy in Passo Fundo, South of Brazil[J]. Arq Bras Endocrinol Metabol, 2007, 51(6): 987-992.
5. 　姚丹珍, 王立, 修雙玲. 糖尿病周圍神經病變檢測方法的研究進展[J]. 臨床誤診誤治, 2010, 23(10): 978-979.
6. 　Feng Y, Schlosser FJ, Sumpio BE. The Semmes Wein-stein monofilament examination as a screening tool for diabetic peripheral neuropathy[J]. J Vasc Surg, 2009, 50(3): 675-682.
7. 　Dros J, Wewerinke A, Bindels P J, et al. Accuracy of monofilament testing to diagnose peripheral neuropathy: asystematic review[J]. Ann Faro Med, 2009, 7(6): 555-558.
8. 　Wooten K. Clinical features and electrodiagnosis of diabet-ic peripheral neuropathy in the dysvascular patient[J]. Phys Med Rehabil Clin N Am, 2009, 20(4): 657-676.
9. 　Hyllienmark L, Jonsson B, Ekberg K, et al. Abnormal cold perception in the lower limbs: a sensitive indicator for detection of polyneuropathy in patients with type 1 diabetes mellitus[J]. Diabetes Res Clin Pract, 2009, 85(3): 298-303.
10. 　Sommer C. Skin biopsy as a diagnostic tool[J]. Curr Opin Neurol, 2008, 21(5): 563-568.
11. 　薛瑩, 劉超. 糖尿病神經病變發病機制的研究進展[J]. 醫學綜述, 2007, 13(10): 761.
12. 　馬蓮茹. 糖尿病神經病變的認識和評估方法[J]. 山西醫藥雜志, 2010, 39(4): 324.

West China Medical Journal

糖尿病患者神經損害及其危險因素分析

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