【摘要】 目的 探討后程適形放射治療（3 dimensional comformal radiation therapy，3D-CRT）同步化學療法治療Ⅲ期非小細胞肺癌（non-small-cell lung cancer，NSCLC）的近期療效。 方法 搜集2005年1月-2008年6月NSCLC患者共115例，其中53例行單純后程3D-CRT（單放組），62例行后程3D-CRT聯合同步化學療法（聯合組），所有患者均經病理證實為Ⅲ期NSCLC。兩組放射治療方案均采用常規分割治療加后程3D-CRT，DT 62～72 Gy。聯合組化學療法采用TP（紫杉醇 + 順鉑）方案。 結果 單放組和聯合組近期療效（完全緩解+部分緩解）分別為75.47%、91.94%，差異有統計學意義（P lt;0.05）。單放組和聯合組的治療不良反應主要有白細胞、血小板減少，放射性食管炎，放射性氣管炎，惡心、嘔吐等胃腸道反應。骨髓抑制和消化道反應，聯合組稍高于單放組。經對癥治療后，所有患者均可耐受。 結論 后程3D-CRT聯合TP方案化學療法較單純后程適形放射治療明顯提高Ⅲ期NSCLC近期療效。患者耐受性尚可。
【Abstract】 Objective To observe the recent therapeutic effect of late course 3 dimensional conformal therapy concomitant with chemotherapy on locally advanced stage Ⅲ non-small-cell lung cancer (NSCLC). Methods From January 2005 to June 2008, 115 patients with stage Ⅲ NSCLC were confirmed by pathology, in whom 53 only underwent late course conformal therapy (radiotherapy group), and another 62 underwent late course conformal therapy concomitant with chemotherapy (combined group). The radiotherapy schema of the two groups was routine division plus late course conformal therapy (with DT 62-72 Gy). The chemotherapy schema in the combined group was performed with TP (paclitaxel and DDP). Results The recent curative effect (complete remission plus partial remission) in radiotherapy group and combined group was 75.47% and 91.94%, respectively (P lt;0.05). The frequent adverse reactions in the two groups included leucocytopenia, thrombocytopenia, radioactive esophagitis, radioactive tracheitis, nauseated, and emesia. The rate of bone marrow depression and alimentary canal reaction in combined group was higher than that in the radiotherapy group. In the two groups, all patients could tolerance the treatments. Conclusion Late course 3 dimensional conformal therapy concomitant with TP schema chemotherapy for NSCLC could raise the recent curative effect. The patients could tolerance the treatments.
引用本文： 趙彩霞,任勇軍,文世民,李光明,潘榮強. 后程適形放射治療聯合化學療法治療Ⅲ期非小細胞肺癌近期療效觀察. 華西醫學, 2011, 26(2): 216-218. doi: 復制