【摘要】　目的　 觀察根除幽門螺桿菌對糖尿病胃輕癱（DGP）的治療作用。　方法　 選擇2008年3月-2010年1月100例幽門螺桿菌陽性DGP患者。隨機分為A、B兩組。A組給予莫沙比利5 mg，3次/d，4周，及根除幽門螺桿菌治療（埃索美拉唑 20 mg+克拉霉素 500 mg+阿莫西林1.0 g，12次/d）2周。B組采用莫沙比利5 mg，3次/d，4周。記錄患者治療前、治療4周及停藥4周時的癥狀積分。　結果　 92例完成實驗。A組癥狀積分治療4周后明顯下降（P lt;0.01），與停藥4周后相比差異無統計學意義（P gt;0.05），二者均明顯低于B組同期（P lt;0.05、 lt;0.01）。B組癥狀積分治療4周后明顯下降（P lt;0.01），停藥4周后明顯高于治療4周后（P lt;0.05），但仍低于治療前（P lt;0.05）。A組治療4周及停藥4周后顯效率及總有效率分別為57.4%及91.5%、40.4%及83%，明顯高于B組35.6%及75.6%、15.6%及53.3%（P lt;0.05）。　結論　 對幽門螺桿菌陽性的DGP患者根除幽門螺桿菌可明顯提高療效，并有效防止停藥后癥狀復發。
【Abstract】　Objective　 To explore the therapeutic effect of helicobacter pylori (H.pylori) eradication on diabetic gastroparesis (DGP) patients.　Methods　 A total of 100 DGP patients with H.pylori infection diagnosed between March 2008 and January 2010 were included and randomly divided into two groups. The patients in group A underwent the treatment with mosapride 5 mg (thrice per day) for four weeks and H.pylori eradication therapy (esomeprazole 20 mg, twice per day; clarithromycin 500 mg, twice per day; amoxicillin 1.0 g, twice per day for two weeks). The patients in group B was administered with mosapride 5 mg (thrice per day) for four weeks. The symptom scores (SS) were recorded pretreatment, 4 weeks later and 4 weeks after stopping treatment.　Results　 Ninety-two patients finished the study. The SS in group A decreased significantly (P lt;0.01) 4 weeks after the treatment and didn’t differ much from that 4 weeks after stopping the treatment. Both of the SS were lower than those in group B at the same time. In group B, compared with that before the treatment, the SS were much lower than that 4 weeks after the treatment (P lt;0.01) and 4 weeks after stopping the treatment (P lt;0.05); the former was significantly lower than the latter (P lt;0.05). The marked efficacy rate and total efficacy rate in group A were higher than those in group B (4-week treatment: 57.4% and 91.5% vs. 35.6% and 75.6%, 4 weeks after stopping the treatment: 40.4% and 83% vs. 15.6% and 53.3%) (P lt;0.05).　Conclusion　 H.pylori eradication can increase the therapeutic effect on H.pylori positive patients with DGP and reduce the recurrence of the symptoms remarkably.

Citation： JIN Hong,SI Ke. herapeutic Effect of Helicobacter Pylori Eradication on Diabetic Gastroparesis. West China Medical Journal, 2011, 26(2): 189-191. doi: Copy

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