抗菌藥物與細胞色素P450的相關研究_《華西醫學》

作者：

孫家鈺 ,  苗佳

四川大學華西醫院國家藥物臨床試驗機構·GCP中心（成都，610041）;

關鍵詞：

細胞色素P450 抗菌藥物藥物代謝藥物相互作用

視頻：

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抗菌藥物廣泛地應用于臨床各個科室，常常與多種藥物聯合應用而產生藥物相互作用。肝微粒體細胞色素P450是藥物代謝最重要的酶系之一，藥物作用影響其活性是發生藥物相互作用的重要分子機制。了解抗菌藥物與細胞色素P450的相關關系，有助于明確藥物相互作用的分子基礎，有助于指導臨床合理聯合用藥，保障臨床治療更加安全有效。現就抗菌藥物與細胞色素P450的相關研究作一綜述。

引用本文： 孫家鈺,苗佳. 抗菌藥物與細胞色素P450的相關研究. 華西醫學, 2012, 27(7): 982-984. doi: 復制

1.	茹建華, 吳伯鏞. 細胞色素P450酶與用藥選擇[J]. 醫藥導報, 2005, 24(3): 241-242.
2.	楊海峰, 江善祥. 苯巴比妥對雞肝微粒體CYP450活性的影響[J]. 江西農業學報, 2010, 22(5): 138-140.
3.	毛萍, 喬定君, 馬欣榮. 細胞色素P450和醫學[J]. 中國抗生素雜志, 2011, 36(2): 93-101.
4.	崔穎, 張永旺. P450酶的研究進展[J]. 中國新技術新產品, 2009(16): 7-8.
5.	范嵐, 彭向東, 郭志華, 等. CYP450氧化還原酶的遺傳多態對藥物代謝的影響[J]. 中國藥理學通報, 2009, 25(9): 1131-1133.
6.	陳杰, 陳孝. 細胞色素P450基因多態性對藥物療效和安全性的影響[J]. 藥品評價, 2010, 7(4): 58-62.
7.	Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes[J]. Curr Drug Metab, 2009, 10(6): 567-578.
8.	徐田雪, 楊信怡, 趙昆, 等. 藥物代謝酶細胞色素P450 2D6的遺傳多態性研究進展[J]. 中國抗生素雜志, 2009, 34(7): 385-391.
9.	孫宜鋒, 方渡. 新型細胞色素P450氧化酶的發現與篩選[J]. 中國醫藥生物技術, 2011, 6(3): 214-217.
10.	張慧鋒, 王月鵬, 李妍. 細胞色素P450的研究進展[J]. 吉林醫藥學院學報, 2005, 26(3): 174-177.
11.	Hersh EV, Moore PA. Drug interactions in dentistry: the importance of knowing your CYPs[J]. J Am Dent Assoc, 2004, 135(3): 298-311.
12.	Chhun S, Verstuyft C, Rizzo-Padoin N, et al. Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers[J]. Br J Clin Pharmacol, 2009, 68(2): 226-237.
13.	Galetin A, Gertz M, Houston JB. Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions[J]. Drug Metab Pharmacokinet, 2010, 25(1): 28-47.
14.	Vandenbrink BM, Isoherranen N. The role of metabolites in predicting drug-drug interactions: focus on irreversible cytochrome P450 inhibition[J]. Curr Opin Drug Discov Devel, 2010, 13(1): 66-77.
15.	Zhang L, Wei MJ, Zhao CY, et al. Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes[J]. Acta Pharmacol Sin, 2008, 29(12): 1507-1514.
16.	Westphal JF. Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin[J]. Br J Clin Pharmacol, 2000, 50(4): 285-295.
17.	Grönlund J, Saari T, Hagelberg N, et al. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone[J]. J Clin Pharmacol, 2010, 50(1): 101-108.
18.	鄒文, 周文, 歐揚. 琥乙紅霉素和阿司匹林合用對大鼠肝臟細胞色素P450酶的影響[J]. 中國醫院藥學雜志, 2008, 28(7): 505-508.
19.	劉荔, 劉嶸, 吳暢烜, 等. 乳酸卡德沙星對大鼠肝P450酶活性的影響[J]. 中國藥科大學學報, 2007, 38(2): 144-148.
20.	Granfors MT, Backman JT, Neuvonen M, et al. Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism[J]. Clin Pharmacol Ther, 2004, 76(6): 598-606.
21.	Scholz I, Oberwittler H, Riedel KD, et al. Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype[J]. Br J Clin Pharmacol, 2009, 68(6): 906-915.
22.	Shon JH, Yeo CW, Liu KH, et al. Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants[J]. J Clin Pharmacol, 2010, 50(2): 195-204.
23.	Uttayamakul S, Likanonsakul S, Manosuthi W, et al. Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults[J]. AIDS Res Ther, 2010, 7: 8.
24.	Kim SH, Kim SH, Bahn JW, et al. Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis[J]. Pharmacogenomics, 2009, 10(11): 1767-1779.
25.	Shin KH, Kim BH, Kim TE, et al. The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study[J]. Clin Ther, 2009, 31(12): 3009-3020.
26.	Skerjanec A, Wang J, Maren K, et al. Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral Iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers[J]. J Clin Pharmacol, 2010, 50(2): 205-213.

1. 　茹建華, 吳伯鏞. 細胞色素P450酶與用藥選擇[J]. 醫藥導報, 2005, 24(3): 241-242.
2. 　楊海峰, 江善祥. 苯巴比妥對雞肝微粒體CYP450活性的影響[J]. 江西農業學報, 2010, 22(5): 138-140.
3. 　毛萍, 喬定君, 馬欣榮. 細胞色素P450和醫學[J]. 中國抗生素雜志, 2011, 36(2): 93-101.
4. 　崔穎, 張永旺. P450酶的研究進展[J]. 中國新技術新產品, 2009(16): 7-8.
5. 　范嵐, 彭向東, 郭志華, 等. CYP450氧化還原酶的遺傳多態對藥物代謝的影響[J]. 中國藥理學通報, 2009, 25(9): 1131-1133.
6. 　陳杰, 陳孝. 細胞色素P450基因多態性對藥物療效和安全性的影響[J]. 藥品評價, 2010, 7(4): 58-62.
7. 　Chen Y, Goldstein JA. The transcriptional regulation of the human CYP2C genes[J]. Curr Drug Metab, 2009, 10(6): 567-578.
8. 　徐田雪, 楊信怡, 趙昆, 等. 藥物代謝酶細胞色素P450 2D6的遺傳多態性研究進展[J]. 中國抗生素雜志, 2009, 34(7): 385-391.
9. 　孫宜鋒, 方渡. 新型細胞色素P450氧化酶的發現與篩選[J]. 中國醫藥生物技術, 2011, 6(3): 214-217.
10. 　張慧鋒, 王月鵬, 李妍. 細胞色素P450的研究進展[J]. 吉林醫藥學院學報, 2005, 26(3): 174-177.
11. 　Hersh EV, Moore PA. Drug interactions in dentistry: the importance of knowing your CYPs[J]. J Am Dent Assoc, 2004, 135(3): 298-311.
12. 　Chhun S, Verstuyft C, Rizzo-Padoin N, et al. Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers[J]. Br J Clin Pharmacol, 2009, 68(2): 226-237.
13. 　Galetin A, Gertz M, Houston JB. Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions[J]. Drug Metab Pharmacokinet, 2010, 25(1): 28-47.
14. 　Vandenbrink BM, Isoherranen N. The role of metabolites in predicting drug-drug interactions: focus on irreversible cytochrome P450 inhibition[J]. Curr Opin Drug Discov Devel, 2010, 13(1): 66-77.
15. 　Zhang L, Wei MJ, Zhao CY, et al. Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes[J]. Acta Pharmacol Sin, 2008, 29(12): 1507-1514.
16. 　Westphal JF. Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin[J]. Br J Clin Pharmacol, 2000, 50(4): 285-295.
17. 　Grönlund J, Saari T, Hagelberg N, et al. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone[J]. J Clin Pharmacol, 2010, 50(1): 101-108.
18. 　鄒文, 周文, 歐揚. 琥乙紅霉素和阿司匹林合用對大鼠肝臟細胞色素P450酶的影響[J]. 中國醫院藥學雜志, 2008, 28(7): 505-508.
19. 　劉荔, 劉嶸, 吳暢烜, 等. 乳酸卡德沙星對大鼠肝P450酶活性的影響[J]. 中國藥科大學學報, 2007, 38(2): 144-148.
20. 　Granfors MT, Backman JT, Neuvonen M, et al. Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism[J]. Clin Pharmacol Ther, 2004, 76(6): 598-606.
21. 　Scholz I, Oberwittler H, Riedel KD, et al. Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype[J]. Br J Clin Pharmacol, 2009, 68(6): 906-915.
22. 　Shon JH, Yeo CW, Liu KH, et al. Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants[J]. J Clin Pharmacol, 2010, 50(2): 195-204.
23. 　Uttayamakul S, Likanonsakul S, Manosuthi W, et al. Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults[J]. AIDS Res Ther, 2010, 7: 8.
24. 　Kim SH, Kim SH, Bahn JW, et al. Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis[J]. Pharmacogenomics, 2009, 10(11): 1767-1779.
25. 　Shin KH, Kim BH, Kim TE, et al. The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study[J]. Clin Ther, 2009, 31(12): 3009-3020.
26. 　Skerjanec A, Wang J, Maren K, et al. Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral Iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers[J]. J Clin Pharmacol, 2010, 50(2): 205-213.

《華西醫學》

抗菌藥物與細胞色素P450的相關研究

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《華西醫學》

抗菌藥物與細胞色素P450的相關研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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