多發性肌炎外周血白細胞中細胞因子信號轉導蛋白抑制因子基因表達的初步研究_《華西醫學》

作者：

孫月池 ¹ , 鄧林 ² , 孫文翠 ² , 吳永強 ² ,  石桂秀 ^1,2

四川大學華西醫院（成都，610041）1 風濕免疫科，2生物治療國家重點實驗室;

關鍵詞：

細胞因子信號轉導蛋白抑制因子細胞因子誘導的含SH2區域蛋白多發性肌炎

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目的　研究活動期多發性肌炎患者外周血白細胞細胞因子信號轉導蛋白抑制因子（SOCS）1、SOCS2、SOCS3和細胞因子誘導的含SH2區域蛋白1（CIS）與正常人表達的差異，探討SOCS在多發性肌炎發病中可能的作用。方法　2011年6月－12月，采用實時熒光定量聚合酶鏈反應法檢測了14例活動期多發性肌炎患者和14例正常人外周血白細胞中SOCS1、SOCS2、SOCS3和CIS1基因的相對表達量。結果　與對照組相比，多發性肌炎癥患者外周血白細胞基因SOCS 1～3表達明顯降低（P值均＜0.05），CIS1基因的表達較對照組明顯升高（P＜0.05），差異有統計學意義。結論　SOCS基因家族可能參與了多發性肌炎的發病，該蛋白分子家族的成員可能會成為多發性肌炎治療的一種新的候選基因。

引用本文： 孫月池,鄧林,孫文翠,吳永強,石桂秀. 多發性肌炎外周血白細胞中細胞因子信號轉導蛋白抑制因子基因表達的初步研究. 華西醫學, 2012, 27(4): 481-484. doi: 復制

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3.	Endo TA, Masuhara M, Yokouchi M, et al. A new protein containing an SH2 domain that inhibits JAK kinases[J]. Nature, 1997, 387(6636): 921-924.
4.	Yoshimura A, Nishinakamura H, Matsumura Y, et al. Negative regulation of cytokine signaling and immune responses by SOCS proteins[J]. Arthritis Res Ther, 2005, 7(3): 100-110.
5.	Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system[J]. Nat Rev Immunol, 2002, 2(6): 410-416.
6.	Alexander WS, Hilton DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response[J]. Annu Rev Immunol, 2004, 22: 503-529.
7.	Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity[J]. Nat Immunol, 2003, 4(12): 1169-1176.
8.	Bohan A, Peter JB.Polymyositis and dermatomyositis (second of two parts) [J]. N Engl J Med, 1975, 292(8): 403-407.
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10.	Miller FW, Rider LG, Chung YL, et al. Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies[J]. Rheumatology (Oxford), 2001, 40(11): 1262-1273.
11.	Hanada T, Kinjyo I, Inagaki-Ohara K, et al. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases[J]. Rev Physiol Biochem Pharmacol, 2003, 149: 72-86.
12.	Chan HC, Ke LY, Chang LL, et al. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus[J]. Lupus, 2010, 19(6): 696-702.
13.	Isomaki P, Alanärä T, Isohanni P, et al. The expression of SOCS is altered in rheumatoid arthritis[J]. Rheumatology (Oxford), 2007, 46(10): 1538-1546.
14.	Walker JG, Smith MD. The Jak-STAT pathway in rheumatoid arthritis[J]. J Rheumatol, 2005, 32(9): 1650-1653.
15.	李蘇芬, 方敬愛, 孫艷艷, 等. 阿托伐他汀對糖尿病腎病大鼠腎組織中JAK/STAT信號通路及其抑制因子SOCS-1表達的影響[J]. 中國中西醫結合腎病雜志, 2011, 12(9): 765-768.
16.	Veenbergen S, Bennink MB, Affandi AJ, et al. A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis[J]. Ann Rheum Dis, 2011, 70(12): 2167-2175.
17.	Ramgolam VS, Markovic-Plese S. Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis[J]. J Signal Transduct, 2011, 2011: doi: IO.1155/2011/635721.
18.	Matsumoto A, Masuhara M, Mitsui K, et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation[J]. Blood, 1997, 89(9): 3148-3154.
19.	Tsao JT, Kuo CC, Lin SC. The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients[J]. Clin Exp Med, 2008, 8(4): 179-185.

1. 　Lundberg IE. New possibilities to achieve increased understanding of disease mechanisms in idiopathic inflammatory myopathies[J]. Curr Opin Rheumatol, 2002, 14(6): 639-642.
2. 　Starr R, Willson TA, Viney EM, et al. A family of cytokine-inducible inhibitors of signalling[J]. Nature, 1997, 387(6636): 917-921.
3. 　Endo TA, Masuhara M, Yokouchi M, et al. A new protein containing an SH2 domain that inhibits JAK kinases[J]. Nature, 1997, 387(6636): 921-924.
4. 　Yoshimura A, Nishinakamura H, Matsumura Y, et al. Negative regulation of cytokine signaling and immune responses by SOCS proteins[J]. Arthritis Res Ther, 2005, 7(3): 100-110.
5. 　Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system[J]. Nat Rev Immunol, 2002, 2(6): 410-416.
6. 　Alexander WS, Hilton DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response[J]. Annu Rev Immunol, 2004, 22: 503-529.
7. 　Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity[J]. Nat Immunol, 2003, 4(12): 1169-1176.
8. 　Bohan A, Peter JB.Polymyositis and dermatomyositis (second of two parts) [J]. N Engl J Med, 1975, 292(8): 403-407.
9. 　Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts) [J]. N Engl J Med, 1975, 292(7): 344-347.
10. 　Miller FW, Rider LG, Chung YL, et al. Proposed preliminary core set measures for disease outcome assessment in adult and juvenile idiopathic inflammatory myopathies[J]. Rheumatology (Oxford), 2001, 40(11): 1262-1273.
11. 　Hanada T, Kinjyo I, Inagaki-Ohara K, et al. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases[J]. Rev Physiol Biochem Pharmacol, 2003, 149: 72-86.
12. 　Chan HC, Ke LY, Chang LL, et al. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus[J]. Lupus, 2010, 19(6): 696-702.
13. 　Isomaki P, Alanärä T, Isohanni P, et al. The expression of SOCS is altered in rheumatoid arthritis[J]. Rheumatology (Oxford), 2007, 46(10): 1538-1546.
14. 　Walker JG, Smith MD. The Jak-STAT pathway in rheumatoid arthritis[J]. J Rheumatol, 2005, 32(9): 1650-1653.
15. 　李蘇芬, 方敬愛, 孫艷艷, 等. 阿托伐他汀對糖尿病腎病大鼠腎組織中JAK/STAT信號通路及其抑制因子SOCS-1表達的影響[J]. 中國中西醫結合腎病雜志, 2011, 12(9): 765-768.
16. 　Veenbergen S, Bennink MB, Affandi AJ, et al. A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis[J]. Ann Rheum Dis, 2011, 70(12): 2167-2175.
17. 　Ramgolam VS, Markovic-Plese S. Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis[J]. J Signal Transduct, 2011, 2011: doi: IO.1155/2011/635721.
18. 　Matsumoto A, Masuhara M, Mitsui K, et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation[J]. Blood, 1997, 89(9): 3148-3154.
19. 　Tsao JT, Kuo CC, Lin SC. The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients[J]. Clin Exp Med, 2008, 8(4): 179-185.

《華西醫學》

多發性肌炎外周血白細胞中細胞因子信號轉導蛋白抑制因子基因表達的初步研究

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《華西醫學》

多發性肌炎外周血白細胞中細胞因子信號轉導蛋白抑制因子基因表達的初步研究

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