胃癌腫瘤干細胞研究現狀及相關問題_《華西醫學》

作者：

張明鳴 , 夏霖 , 楊平 ,  伍曉汀

四川大學華西醫院胃腸外科中心（成都，610041）;

關鍵詞：

腫瘤干細胞胃癌胃癌干細胞

視頻：

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腫瘤干細胞學說是近年來快速發展和備受關注的一個理論，根據該學說，具有自我更新、多向分化、無限生長和很強成瘤能力的癌干細胞可能是腫瘤發生、發展、侵襲和復發轉移的根源。當前，已有多種類型的癌干細胞被證實或探討，然而胃癌干細胞的研究尚存在困難，相關報道很少。現就國內外近年來關于癌干細胞和胃癌干細胞的相關研究進展進行綜述，探討胃癌干細胞的培養、分離、確認鑒定及其復雜的生物學特征研究中尚面臨的一些亟待解決的問題。

引用本文： 張明鳴,夏霖,楊平,伍曉汀. 胃癌腫瘤干細胞研究現狀及相關問題. 華西醫學, 2012, 27(3): 452-454. doi: 復制

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8.	Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumor initiating cells[J]. Nature, 2004, 432(7015): 396-401.
9.	Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells[J]. Cancer Res, 2005, 65(23): 10946-10951.
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15.	Hiraga T, Ito S, Nakamura H. Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential[J]. Oncol Rep, 2011, 25(1): 289-296.
16.	Hadnagy A, Gaboury L, Beaulieu R, et al. SP analysis May be used to identify cancer stem cell populations[J]. Exp Cell Res, 2006, 312(19): 3701-3710.
17.	Triel C, Vestergaard ME, Bolund L, et al. Side population cells in human and mouse epidermis lack stem cell characteristics[J]. Exp Cell Res, 2004, 295(1): 79-90.
18.	Gaston-Massuet C, Andoniadou CL, Signore M, et al. Increased wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans[J]. Proc Natl Acad Sci USA, 2011, 108(28): 11482-11487.
19.	Lei Y, Huang K, Gao C, et al. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells[J]. Mol Cell Proteomics, 2011, 10(10): M110.005397.
20.	Dolai S, Xu Q, Liu F, et al. Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells[J]. Proteomics, 2011, 11(13): 2683-2692.
21.	Izumiya M, Okamoto K, Tsuchiya N, et al. Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs[J]. Carcinogenesis, 2010, 31(8): 1354-1359.
22.	Krutovskikh VA, micrornas HO. As a new class of cancer biomarkers[J]. Bioessays, 2010, 32(10): 894-904.
23.	張祖斌, 顧振綸, 蔣小崗, 等. miRNA在腫瘤及腫瘤干細胞中作用的研究進展[J]. 中國藥理學通報, 2009, 25(3): 297-299.
24.	Kitade Y, Akao Y. MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug[J]. J Pharmacol Sci, 2010, 114(3): 276-280.
25.	Akao Y, Nakagawa Y, Hirata I, et al. Role of anti-oncomirs miR-143 and -145 in human colorectal tumors[J]. Cancer Gene Ther, 2010, 17(6): 398-408.

1. 　Bhattacharyya S, Khanduja KL. New hope in the horizon: cancer stem cells[J]. Acta Biochim Biophys Sin (Shanghai), 2010, 42(4): 237-242.
2. 　Velasco-Velázquez MA, Popov VM, Lisanti MP, et al. The role of breast cancer stem cells in metastasis and therapeutic implications[J]. Am J Pathol, 2011, 179(1): 2-11.
3. 　Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859): 105-111.
4. 　Scopelliti A, Cammareri P, Catalano V, et al. Therapeutic implications of cancer iitiating cells[J]. Expert Opin Biol Ther, 2009, 9(8): 1005-1016.
5. 　Subramaniam D, Ramalingam S, Houchen CW, et al. Cancer stem cells: a novel paradigm for cancer prevention and treatment[J]. Mini Rev Med Chem, 2010, 10(5): 359-371.
6. 　Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J]. Nat Med, 1997, 3(7): 730-737.
7. 　Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells[J]. Proc Natl Acad Sci USA, 2003, 100(7): 3983-3988.
8. 　Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumor initiating cells[J]. Nature, 2004, 432(7015): 396-401.
9. 　Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells[J]. Cancer Res, 2005, 65(23): 10946-10951.
10. 　Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells[J]. Methods Mol Biol, 2009, 568: 161-173.
11. 　Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells[J]. Nature, 2007, 445(7123): 111-115.
12. 　Guo R, Wu Q, Liu F, et al. Description of the CD133+ subpopulation of the human ovarian cancer cell line OVCAR3[J]. Oncol Rep, 2011, 25(1): 141-146.
13. 　Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells[J]. Cell, 2007, 131(6): 1109-1123.
14. 　Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors[J]. Proc Natl Acad Sci USA, 2003, 100(25): 15178-15183.
15. 　Hiraga T, Ito S, Nakamura H. Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential[J]. Oncol Rep, 2011, 25(1): 289-296.
16. 　Hadnagy A, Gaboury L, Beaulieu R, et al. SP analysis May be used to identify cancer stem cell populations[J]. Exp Cell Res, 2006, 312(19): 3701-3710.
17. 　Triel C, Vestergaard ME, Bolund L, et al. Side population cells in human and mouse epidermis lack stem cell characteristics[J]. Exp Cell Res, 2004, 295(1): 79-90.
18. 　Gaston-Massuet C, Andoniadou CL, Signore M, et al. Increased wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans[J]. Proc Natl Acad Sci USA, 2011, 108(28): 11482-11487.
19. 　Lei Y, Huang K, Gao C, et al. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells[J]. Mol Cell Proteomics, 2011, 10(10): M110.005397.
20. 　Dolai S, Xu Q, Liu F, et al. Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells[J]. Proteomics, 2011, 11(13): 2683-2692.
21. 　Izumiya M, Okamoto K, Tsuchiya N, et al. Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs[J]. Carcinogenesis, 2010, 31(8): 1354-1359.
22. 　Krutovskikh VA, micrornas HO. As a new class of cancer biomarkers[J]. Bioessays, 2010, 32(10): 894-904.
23. 　張祖斌, 顧振綸, 蔣小崗, 等. miRNA在腫瘤及腫瘤干細胞中作用的研究進展[J]. 中國藥理學通報, 2009, 25(3): 297-299.
24. 　Kitade Y, Akao Y. MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug[J]. J Pharmacol Sci, 2010, 114(3): 276-280.
25. 　Akao Y, Nakagawa Y, Hirata I, et al. Role of anti-oncomirs miR-143 and -145 in human colorectal tumors[J]. Cancer Gene Ther, 2010, 17(6): 398-408.

《華西醫學》

胃癌腫瘤干細胞研究現狀及相關問題

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《華西醫學》

胃癌腫瘤干細胞研究現狀及相關問題

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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