納米級超聲造影劑的技術進展_《華西醫學》

作者：

張美琴 ¹ , 周彩云 ² ,  羅紅 ¹

1四川大學華西第二醫院超聲科（成都，610041）;2浙江大學醫學院附屬婦產醫院超聲科;

關鍵詞：

納米造影劑載藥高分子聚合物脂質體

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納米級超聲造影劑是指直徑＜1 000 nm的超聲造影劑。與微米級微泡相比，納米造影劑粒徑較小，滲透能力極強，可以通過血管內皮間隙，進行病變部位血管外顯影。同時因為納米系統具有一定的靶向能力，將納米級造影系統與臨床治療相結合可以在腫瘤治療方面表現出其特定的靶向治療優勢。現就納米級超聲造影劑的特征、國內外制備方法及研究前景進行總結。

引用本文： 張美琴,周彩云,羅紅. 納米級超聲造影劑的技術進展. 華西醫學, 2012, 27(10): 1585-1587. doi: 復制

1.	Gramiak R, Shah PM, Kramer DH. Ultrasound cardiography: contrast studies in anatomy and function[J]. Radiology, 1969, 92(5): 939-948.
2.	鄭平. 超聲對比造影的應用[J].中國分子心臟病學雜志, 2010, 10(4): 241-244.
3.	Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma[J]. J Hepatol , 2008, 48(5): 848-857.
4.	Görg C. The forgotten organ: contrast enhanced sonography of the spleen[J]. Eur J Radiol, 2007, 64(2): 189-201.
5.	李凱,鄭榮琴.輸卵管的超聲造影表現[J].中國超聲診斷雜志, 2006,7(10): 745-747.
6.	Gaur U, Sahoo SK, De TK, et al. Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system[J]. Int J Pharm, 2000, 202(1-2): 1-10.
7.	Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis[J]. Adv Drug Deliv Rev, 2002, 54(5): 631-651.
8.	Lanza GM, Winter PM, Caruthers SD, et al. Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions[J] . Angiogenesis, 2010, 13(2): 189-202.
9.	杜永峰, 于銘, 閆燁. 微泡超聲造影劑材料研究進展[J].功能材料, 2004, 35(增刊): 2473-2476.
10.	曹銀, 張洪波.超聲造影劑制備方法[J],中國超聲醫學雜志, 2010, 26(9): 858-862.
11.	Hadinoto K. Mechanical stability of hollow spherical nano-aggregates as ultrasound contrast agent[J]. Int J Pharm, 2009, 374(1-2): 153-161.
12.	Wang Y, Li X, Zhou Y, et al. Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery[J]. Int J Pharm, 2010, 384(1-2): 148-53.
13.	Forsberg F, Lathia JD, Merton DA, et al. of shell type on the in vivo backscatter from polymer-encapsulated microbubbles[J]. Ultrasound Med Biol, 2004, 30 (10): 1281-1287.
14.	Sciallero C, Paradossi G, Trucco A. A preliminary in vitro assessment of polymer-shelled microbubbles in contrast-enhanced ultrasound imaging[J]. Ultrasonics, 2012, 52 (3): 456-464.
15.	Néstor MM, Kei NP, Guadalupe NA, et al. Preparation and in vitro evaluation of poly(D, L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging[J]. Ultrasonics, 2011, 51(7): 839-845.
16.	劉欣欣, 王衍戈，朱佩娟，等. 納米級載藥微泡的制備及其超聲介導下的抑瘤研究[J]. 廈門大學學報(自然科學版), 2010, 49(6): 874-879.
17.	Wheatley MA, Lewandowski J. Nano-sized ultrasound contrast agent:salting-out method[J]. Mol Imaging, 2010, 9(2): 96-107.
18.	Rapoport N, Gao Z, Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy[J]. J Natl Cancer Inst, 2007, 99(14): 1095-1106.
19.	Rapoport N, Kennedy AM, Shea JE, et al. Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging[J]. Mol Pharm, 2010, 7(1): 22-31.
20.	Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions[J]. J Control Release, 2011, 153(1): 4-15.
21.	Mohan P, Rapoport N. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intra cellular delivery[J]. Mol Pharm, 2010, 7(6): 1959-1973.
22.	Díaz-López R, Tsapis N, Santin M, et al. The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent[J]. Biomaterials, 2010, 31(7): 1723-1731.
23.	王平, 尹庭輝, 鄭榮琴. 新型納米微泡超聲造影劑的制備及超聲顯像研究[J]. 中山大學學報（醫學科學版）, 2011, 32(3): 327-330.
24.	馮敏, 趙洪洋, 張麗, 等.納米級脂質微泡的制備及其在動脈血栓檢測中的應用[J].臨床心血管病雜志, 2009, 25(12): 896-898.
25.	Marxer EE, Brüssler J, Becker A, et al. Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents[J]. Eur J Pharm Biopharm, 2011, 77 (3): 430-437.
26.	Wang D, Yang K, Gao YH, et al. Preparation and characterization of a nanoscale ultrasound contrast agent[J]. Clin Imaging, 2010, 34(4): 288-292.
27.	Becker A, Marxer E, Brüssler J, et al. Ultrasound active nanoscaled lipid formulations for thrombus lysis[J]. Eur J Pharm Biopharm, 2011, 77(3): 424-429.

1. 　Gramiak R, Shah PM, Kramer DH. Ultrasound cardiography: contrast studies in anatomy and function[J]. Radiology, 1969, 92(5): 939-948.
2. 　鄭平. 超聲對比造影的應用[J].中國分子心臟病學雜志, 2010, 10(4): 241-244.
3. 　Lencioni R, Piscaglia F, Bolondi L. Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma[J]. J Hepatol , 2008, 48(5): 848-857.
4. 　Görg C. The forgotten organ: contrast enhanced sonography of the spleen[J]. Eur J Radiol, 2007, 64(2): 189-201.
5. 　李凱,鄭榮琴.輸卵管的超聲造影表現[J].中國超聲診斷雜志, 2006,7(10): 745-747.
6. 　Gaur U, Sahoo SK, De TK, et al. Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system[J]. Int J Pharm, 2000, 202(1-2): 1-10.
7. 　Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis[J]. Adv Drug Deliv Rev, 2002, 54(5): 631-651.
8. 　Lanza GM, Winter PM, Caruthers SD, et al. Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions[J] . Angiogenesis, 2010, 13(2): 189-202.
9. 　杜永峰, 于銘, 閆燁. 微泡超聲造影劑材料研究進展[J].功能材料, 2004, 35(增刊): 2473-2476.
10. 　曹銀, 張洪波.超聲造影劑制備方法[J],中國超聲醫學雜志, 2010, 26(9): 858-862.
11. 　Hadinoto K. Mechanical stability of hollow spherical nano-aggregates as ultrasound contrast agent[J]. Int J Pharm, 2009, 374(1-2): 153-161.
12. 　Wang Y, Li X, Zhou Y, et al. Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery[J]. Int J Pharm, 2010, 384(1-2): 148-53.
13. 　Forsberg F, Lathia JD, Merton DA, et al. of shell type on the in vivo backscatter from polymer-encapsulated microbubbles[J]. Ultrasound Med Biol, 2004, 30 (10): 1281-1287.
14. 　Sciallero C, Paradossi G, Trucco A. A preliminary in vitro assessment of polymer-shelled microbubbles in contrast-enhanced ultrasound imaging[J]. Ultrasonics, 2012, 52 (3): 456-464.
15. 　Néstor MM, Kei NP, Guadalupe NA, et al. Preparation and in vitro evaluation of poly(D, L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging[J]. Ultrasonics, 2011, 51(7): 839-845.
16. 　劉欣欣, 王衍戈，朱佩娟，等. 納米級載藥微泡的制備及其超聲介導下的抑瘤研究[J]. 廈門大學學報(自然科學版), 2010, 49(6): 874-879.
17. 　Wheatley MA, Lewandowski J. Nano-sized ultrasound contrast agent:salting-out method[J]. Mol Imaging, 2010, 9(2): 96-107.
18. 　Rapoport N, Gao Z, Kennedy A. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy[J]. J Natl Cancer Inst, 2007, 99(14): 1095-1106.
19. 　Rapoport N, Kennedy AM, Shea JE, et al. Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging[J]. Mol Pharm, 2010, 7(1): 22-31.
20. 　Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions[J]. J Control Release, 2011, 153(1): 4-15.
21. 　Mohan P, Rapoport N. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intra cellular delivery[J]. Mol Pharm, 2010, 7(6): 1959-1973.
22. 　Díaz-López R, Tsapis N, Santin M, et al. The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent[J]. Biomaterials, 2010, 31(7): 1723-1731.
23. 　王平, 尹庭輝, 鄭榮琴. 新型納米微泡超聲造影劑的制備及超聲顯像研究[J]. 中山大學學報（醫學科學版）, 2011, 32(3): 327-330.
24. 　馮敏, 趙洪洋, 張麗, 等.納米級脂質微泡的制備及其在動脈血栓檢測中的應用[J].臨床心血管病雜志, 2009, 25(12): 896-898.
25. 　Marxer EE, Brüssler J, Becker A, et al. Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents[J]. Eur J Pharm Biopharm, 2011, 77 (3): 430-437.
26. 　Wang D, Yang K, Gao YH, et al. Preparation and characterization of a nanoscale ultrasound contrast agent[J]. Clin Imaging, 2010, 34(4): 288-292.
27. 　Becker A, Marxer E, Brüssler J, et al. Ultrasound active nanoscaled lipid formulations for thrombus lysis[J]. Eur J Pharm Biopharm, 2011, 77(3): 424-429.

《華西醫學》

納米級超聲造影劑的技術進展

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《華西醫學》

納米級超聲造影劑的技術進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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