蜂毒主動免疫對預防蜂蜇傷嚴重毒效應的研究進展_《華西醫學》

作者：

劉鵬 , 倪芬 , 許樹云 ,  曹鈺

四川大學華西醫院急診科（成都，610041）;

關鍵詞：

蜂蜇傷速發型過敏反應蜂毒液主動免疫療效

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蜂蜇傷屬于常見動物致傷病，傷后輕者可出現局部紅腫熱痛，部分患者中毒癥狀明顯，甚至因感染或多臟器功能不全而死亡。目前國內對蜂蜇傷的治療基本局限于對癥治療和支持治療，很少采取主動免疫方式防患于未然。蜂毒液主動免疫即是將少量蜂毒提取液對高危人群進行注射，以使其獲得主動免疫的方法，效果確切，安全性高，已成為國外防治蜂蜇傷嚴重中毒反應的最主要方法。現就蜂毒液主動免疫的應用機制、安全性、應用范圍、使用方法等作一闡述。

引用本文： 劉鵬,倪芬,許樹云,曹鈺. 蜂毒主動免疫對預防蜂蜇傷嚴重毒效應的研究進展. 華西醫學, 2012, 27(10): 1575-1577. doi: 復制

1.	Bilò BM, Bonifazi F. Epidemiology of insect – venomanaphylaxis[J]. Curr Opin Allergy Clin Immunol, 2008, 8(4): 330-337.
2.	Przybilla B, Ruëff F. Desensitization of allergy to hymenoptera venoms[J]. Wien Med Wochenschr, 1999, 149(14-15): 421-428.
3.	Golden D. Stinging insect allergy[J]. Am Fam Physician, 2003, 67 (12): 2541-2546.
4.	Prado M, Quirós D, Lomonte B. Mortality due to hymenoptera stings in Costa Rica, 1985-2006[J]. Rev Panam Salud Publica, 2009, 25(5): 389-393.
5.	Blacklow B, Escoubas P, Nicholson GM. Characterisation of theheterotrimeric presynaptic hospholipaseA(2) neurotoxin complex from the venom of the common death adder (Acanthophis antarcticus) [J]. Biochem Pharmacol, 2010, 80(2): 277-287.
6.	Roy M, Chatterjee M, Deb S, et al. Encephalitis following wasp sting[J]. Indian J Pediatr, 2010, 77(10): 1193-1194.
7.	Mondal N, Krishnamurthy S, Narayanan P, et al. Bilateral Ptosis in a child following massive attack by a swarm of wasps[J]. J Child Neurol, 2011, 26(10): 1322-1324.
8.	鄒翎, 李崢艷, 孫家瑜, 等. 磁共振成像在蜂蜇傷致橫紋肌溶解診斷中的應用[J].華西醫學, 2010, 25(5): 898-900.
9.	陳懿, 秦敏, 洪蕓. 連續性血液凈化治療蜂蜇傷致急性腎功能衰竭的臨床觀察與護理體會[J]. 華西醫學, 2009, 24(6): 1526-1564.
10.	Rebecca S, Gruchalla. Immunotherapy in allergy to insect stings in children[J]. N Engl J Med, 2004, 351(7): 707-709.
11.	Celikel S, Karakaya G, Yurtsever N, et al. Bee and bee products allergy in Turkish beekeepers: determination of risk factors for systemic reactions[J]. Allergol Immunopathol (Madr), 2006, 34(5): 180-184.
12.	Hamilton RG. Diagnosis and treatment of allergy to hymenoptera venoms[J]. Curr Opin Allergy Clin Immunol, 2010, 10(4): 323-329.
13.	Sabatos-Peyton CA, Verhagen J, Wraith DC. Antigen-specific immunotherapy of autoimmune and allergic diseases[J]. Curr Opin Immunol, 2010, 22(5): 609-615.
14.	Brathwaite N, du Toit G, Lloydhope K, Sinnott L, et al. The RCPCH care pathway for children with venom allergies: an evidence and consensus based national approach[J]. Arch Dis Child, 2011, 96(Suppl 2): 38-40.
15.	何韶衡, 劉志剛. 基礎過敏反應學[M].北京: 科學出版社, 2009: 877-878.
16.	Jackola DR, Pierson-Mullany LK, Liebeler CL, et al. Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans[J]. Mol Immunol, 2002, 39(5-6): 367-377.
17.	Pierson-Mullany LK, Jackola D, Blumenthal M, et al. Altered allergen binding capacities of Amb 1- specific IgE and IgG4 from ragweed-sensitive patiens receiving immunotherapy[J]. Ann Alergy Asthma Immunol, 2000, 84(2): 241-243.
18.	Freeman TM.. Clinical practice. Hypersensitivity to hymenoptera stings[J]. N Engl J Med, 2004, 351(19): 1978-1984.
19.	Roll A, Hofbauer G, Ballmer-Weber BK, et al. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy [J]. J Investig Allergol Immunol, 2006, 16(2): 79-85.
20.	Goldberg A, Con?no-Cohen R. Bee venom immunotherapy—how early is it effective?[J]. Allergy, 2010, 65(3): 391-395 .
21.	Golden DB, Kelly D, Hamilton RG, et al. Venom immunotherapy reduces large local reactions to insect stings[J]. J Allergy Clin Immunol, 2009, 123(6): 1371-1375.

1. 　Bilò BM, Bonifazi F. Epidemiology of insect – venomanaphylaxis[J]. Curr Opin Allergy Clin Immunol, 2008, 8(4): 330-337.
2. 　Przybilla B, Ruëff F. Desensitization of allergy to hymenoptera venoms[J]. Wien Med Wochenschr, 1999, 149(14-15): 421-428.
3. 　Golden D. Stinging insect allergy[J]. Am Fam Physician, 2003, 67 (12): 2541-2546.
4. 　Prado M, Quirós D, Lomonte B. Mortality due to hymenoptera stings in Costa Rica, 1985-2006[J]. Rev Panam Salud Publica, 2009, 25(5): 389-393.
5. 　Blacklow B, Escoubas P, Nicholson GM. Characterisation of theheterotrimeric presynaptic hospholipaseA(2) neurotoxin complex from the venom of the common death adder (Acanthophis antarcticus) [J]. Biochem Pharmacol, 2010, 80(2): 277-287.
6. 　Roy M, Chatterjee M, Deb S, et al. Encephalitis following wasp sting[J]. Indian J Pediatr, 2010, 77(10): 1193-1194.
7. 　Mondal N, Krishnamurthy S, Narayanan P, et al. Bilateral Ptosis in a child following massive attack by a swarm of wasps[J]. J Child Neurol, 2011, 26(10): 1322-1324.
8. 　鄒翎, 李崢艷, 孫家瑜, 等. 磁共振成像在蜂蜇傷致橫紋肌溶解診斷中的應用[J].華西醫學, 2010, 25(5): 898-900.
9. 　陳懿, 秦敏, 洪蕓. 連續性血液凈化治療蜂蜇傷致急性腎功能衰竭的臨床觀察與護理體會[J]. 華西醫學, 2009, 24(6): 1526-1564.
10. 　Rebecca S, Gruchalla. Immunotherapy in allergy to insect stings in children[J]. N Engl J Med, 2004, 351(7): 707-709.
11. 　Celikel S, Karakaya G, Yurtsever N, et al. Bee and bee products allergy in Turkish beekeepers: determination of risk factors for systemic reactions[J]. Allergol Immunopathol (Madr), 2006, 34(5): 180-184.
12. 　Hamilton RG. Diagnosis and treatment of allergy to hymenoptera venoms[J]. Curr Opin Allergy Clin Immunol, 2010, 10(4): 323-329.
13. 　Sabatos-Peyton CA, Verhagen J, Wraith DC. Antigen-specific immunotherapy of autoimmune and allergic diseases[J]. Curr Opin Immunol, 2010, 22(5): 609-615.
14. 　Brathwaite N, du Toit G, Lloydhope K, Sinnott L, et al. The RCPCH care pathway for children with venom allergies: an evidence and consensus based national approach[J]. Arch Dis Child, 2011, 96(Suppl 2): 38-40.
15. 　何韶衡, 劉志剛. 基礎過敏反應學[M].北京: 科學出版社, 2009: 877-878.
16. 　Jackola DR, Pierson-Mullany LK, Liebeler CL, et al. Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans[J]. Mol Immunol, 2002, 39(5-6): 367-377.
17. 　Pierson-Mullany LK, Jackola D, Blumenthal M, et al. Altered allergen binding capacities of Amb 1- specific IgE and IgG4 from ragweed-sensitive patiens receiving immunotherapy[J]. Ann Alergy Asthma Immunol, 2000, 84(2): 241-243.
18. 　Freeman TM.. Clinical practice. Hypersensitivity to hymenoptera stings[J]. N Engl J Med, 2004, 351(19): 1978-1984.
19. 　Roll A, Hofbauer G, Ballmer-Weber BK, et al. Safety of specific immunotherapy using a four-hour ultra-rush induction scheme in bee and wasp allergy [J]. J Investig Allergol Immunol, 2006, 16(2): 79-85.
20. 　Goldberg A, Con?no-Cohen R. Bee venom immunotherapy—how early is it effective?[J]. Allergy, 2010, 65(3): 391-395 .
21. 　Golden DB, Kelly D, Hamilton RG, et al. Venom immunotherapy reduces large local reactions to insect stings[J]. J Allergy Clin Immunol, 2009, 123(6): 1371-1375.

《華西醫學》

蜂毒主動免疫對預防蜂蜇傷嚴重毒效應的研究進展

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《華西醫學》

蜂毒主動免疫對預防蜂蜇傷嚴重毒效應的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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