四種第二代抗組胺藥物的衛生技術評估_《中國循證醫學雜志》

作者：

孫鑫 ¹ , 曹立亞 ⁴ , 馬濤 ² , 蘭奮 ⁴ , 李夏 ² , 肖愛麗 ⁴ , 陳心足 ² , 李幼平 ¹³

1. 四川大學華西醫院,衛生部移植工程與移植免疫重點實驗室,成都,6100412. 四川大學華西臨床醫學院,成都,6100413. 四川大學華西醫院,中國循征醫學中心,成都,6100414. 國家食品與藥品監督管理局,藥品評價中心,北京,100038;

關鍵詞：

阿司咪唑氯雷他丁西替利嗪特非那定過敏性鼻炎蕁麻疹衛生技術評估

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目的　本研究旨在評價阿司咪唑、氯雷他丁、西替利嗪和特非那定四種第二代抗組胺藥物的安全性、有效性和經濟性,為國家基本藥物目錄調整提供依據.
檢索策略 　檢索Medline,Cochrane圖書館,Embase和中國生物醫學文獻數據庫.另檢索14個藥物安全性和經濟學研究數據庫.
納入標準 　中文和英文研究.有效性研究納入比較四種藥物中的兩種用于過敏性鼻炎和蕁麻疹的的高質量隨機對照試驗和系統評價,經濟學研究同時納入非隨機研究.安全性研究納入四種抗組胺藥物用于過敏性疾病導致心臟不良反應的各種級別證據;質量評價隨機對照試驗使用Jadad評價表,另評價分配隱藏和意向性分析.
數據提取和分析 　有效性研究使用固定效應模型,并進行敏感性分析.安全性評價收集不良反應病例數、癥狀和心電圖特征.
結果　尚無經濟學研究.分別有27和6個隨機對照試驗評價抗組胺藥物用于過敏性鼻炎和蕁麻疹.西替利嗪較其他三種藥物總體上更優.分別收集到73和27例有關阿司咪唑和特非那定的心臟不良反應,西替利嗪和氯雷他丁的心臟不良反應報道極少,特非那定和阿司咪唑與其他藥物合用可引起QTc延長.
結論　總體上,西替利嗪較其他三種藥物更有效,阿司咪唑和特非那定易導致心臟不良反應.

引用本文： 孫鑫,曹立亞,馬濤,蘭奮,李夏,肖愛麗,陳心足,李幼平. 四種第二代抗組胺藥物的衛生技術評估. 中國循證醫學雜志, 2003, 03(3): 195-206. doi: 復制

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《中國循證醫學雜志》

四種第二代抗組胺藥物的衛生技術評估

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《中國循證醫學雜志》

四種第二代抗組胺藥物的衛生技術評估

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