降壓治療對腦卒中二級預防的臨床證據_《中國循證醫學雜志》

作者：

王文 , 鄧卿 , 何華 , 馬麗媛

中國醫學科學院阜外心血管病醫院,心血管病研究所,北京,100037;

關鍵詞：

降壓治療腦卒中二級預防臨床證據

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目的　綜合分析與腦卒中有關的降壓治療大樣本隨機對照試驗,為腦卒中二級預防提供臨床證據.
方法　計算機檢索Medline(1966～2003年6月),對已公開發表的大樣本隨機對照降壓治療預防腦卒中再發的臨床試驗進行綜合分析.分析指標為腦卒中事件、冠心病事件及總死亡率等.
結果　共納入腦卒中后抗高血壓治療的隨機對照試驗(PATS)、多中心培哚普利降壓治療腦卒中/一過性腦缺血發作的隨機對照臨床試驗(PROGRESS)和心臟結局預防評估研究(HOPE)3個試驗進行綜合分析.結果顯示:降壓治療組較安慰劑對照組降低腦卒中再發危險率28%,降低冠心病危險率15%,降低總死亡率11%;降壓治療不僅能降低腦血管病或心血管病高危者伴高血壓的腦卒中再發危險,而且對未伴高血壓者也能降低其腦卒中危險.
結論　降壓治療對腦卒中二級預防是有益的.

引用本文： 王文,鄧卿,何華,馬麗媛. 降壓治療對腦卒中二級預防的臨床證據. 中國循證醫學雜志, 2004, 04(5): 355-358. doi: 復制

1.	［1］Wang W, Lin LS. Relationship between blood pressure level and stroke recurrence[J]. Chin J Hypertens, 2003; 11:106 -108.
2.	［2］PATS Collaborating Group. Post-stroke antihypertensive treatment study (PATS) , a preliminary result [ J ]. Chin Med J (Engl), 1995; 108(9) :710 -717.
3.	［3］PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood pressure-lowering regimen among 6 105 individuals with previous stroke or transient ischemic attack[J]. Lancet, 2001; 358(9 287):1 033-1 041.
4.	［4］Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G.Effects of an angiotensin-eonverting-enzyme inhibitor, ramipril,on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators[ J]. N Engl J Med, 2000; 342(3):145-153.
5.	［5］Dutch TIA Trial Group. Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke[J]. Stroke, 1993; 24(4) :543 -548.
6.	［6］Rodgers A, Neal B, MacMahon S. The effects of blood pressure lowering in cerebrovascular disease [ J ]. Neurol Rev Int,1997; 2:12-15.
7.	［7］Hypertension Stroke Cooperative Study Group. Effect of antihypertensive treatment on stroke recurrence[J]. J Am Med Assoc, 1974; 229:409 - 418.

1. ［1］Wang W, Lin LS. Relationship between blood pressure level and stroke recurrence[J]. Chin J Hypertens, 2003; 11:106 -108.
2. ［2］PATS Collaborating Group. Post-stroke antihypertensive treatment study (PATS) , a preliminary result [ J ]. Chin Med J (Engl), 1995; 108(9) :710 -717.
3. ［3］PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood pressure-lowering regimen among 6 105 individuals with previous stroke or transient ischemic attack[J]. Lancet, 2001; 358(9 287):1 033-1 041.
4. ［4］Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G.Effects of an angiotensin-eonverting-enzyme inhibitor, ramipril,on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators[ J]. N Engl J Med, 2000; 342(3):145-153.
5. ［5］Dutch TIA Trial Group. Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke[J]. Stroke, 1993; 24(4) :543 -548.
6. ［6］Rodgers A, Neal B, MacMahon S. The effects of blood pressure lowering in cerebrovascular disease [ J ]. Neurol Rev Int,1997; 2:12-15.
7. ［7］Hypertension Stroke Cooperative Study Group. Effect of antihypertensive treatment on stroke recurrence[J]. J Am Med Assoc, 1974; 229:409 - 418.

《中國循證醫學雜志》

降壓治療對腦卒中二級預防的臨床證據

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《中國循證醫學雜志》

降壓治療對腦卒中二級預防的臨床證據

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料