精神分裂癥高危人群認知功能研究_《中國循證醫學雜志》

作者：

 姚靜 ¹ , 郭蘭婷 ² , 孫錦華 ² , 周為 ¹ , 王強 ² , 馬小紅 ² , 劉協和 ² , 黃宣銀 ¹ , 李濤 ²

1. 四川省綿陽市第三人民醫院精神科（綿陽 621000） 2. 四川大學華西醫院精神科（成都 610041）;

關鍵詞：

精神分裂癥高危人群認知功能神經心理學測驗

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目的　探討精神分裂癥高危人群認知功能的特點。
方法　選用14項神經心理測驗對222例精神分裂癥高危個體及331名正常對照個體進行認知功能的評定與比較。
結果　在知識總分、算術總分、數字符號總分、木塊拼圖總分、即刻邏輯記憶分、延遲邏輯記憶分、即刻視覺記憶A分、即刻視覺記憶B分、言語流暢正確數、Hanoi塔計劃時間、Hanoi塔執行時間、Hanoi塔總分、WCST分類數、WCST持續錯誤數和CPT反應時上，精神分裂癥高危組的成績明顯差于正常對照組（P lt;0.01）；高危組在連線測驗A完成時間上長于正常對照組（P lt;0.05）。
結論　精神分裂癥高危人群存在廣泛的認知功能損害。精神分裂癥高危人群所具有的持續注意和執行功能障礙，可考慮作為精神分裂癥的“內表型”指標。

引用本文： 姚靜,郭蘭婷,孫錦華,周為,王強,馬小紅,劉協和,黃宣銀,李濤. 精神分裂癥高危人群認知功能研究. 中國循證醫學雜志, 2006, 06(8): 563-566. doi: 復制

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1. Byrne M, Clafferty BA, Cosway R, et al. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia. J Abnorm Psychol, 2003; 112(1): 38-48.
2. Gottesman II, McGue M. Mixed and mixed-up models for the transmission of schizophrenia. Minneapolis: University of Minnesota Press.1991.
3. Compton DM，Bachman LD，Brand D, et al. Age-associated changes in cognitive function in highly educated adults：emerging myths and realities．Int J Geriatr Psychiatry, 2000; 15(1): 75-85.
4. Archila A, Moreno S. Neuropsychological test performance in Auuaco Indians：an exploratory study．J Int Neuropsychol Soc, 2001; 7(4): 510-515.
5. Georgopoulos AP, Whang K, Georgopoulos MA, et al. Functional magnetic resonance imaging of visual object construction and shape discrimination: relations among task, hemispheric lateralization and gender. J Cogn Neurosci, 2001; 13(1): 72-89.
6. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophreia. Am J Med Genet, 2000; 97: 52-57.
7. Hoff AL, Svetina C, Maurizio AM, et al. Familial cognitive deficits in schizophrenia. Am. J. Med. Genet., 2005; 133B: 43-49.
8. Akdede B, Alptekin K, Kiti A, et al. Effects of quetiapine on cognitive functions in schizophrenia.Prog. Neuropsychopharmacol. Biol. Psychiatry, 2005; 29: 233-238.
9. Bustini M, Stratta P, Daneluzzo E, et al. Tower of Hanoi and WCST performance in schizophrenia: problem-solving capacity and clinical correlates. J Psychiatr Res, 1999; 33(3): 285-290.

《中國循證醫學雜志》

精神分裂癥高危人群認知功能研究

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《中國循證醫學雜志》

精神分裂癥高危人群認知功能研究

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