托吡酯治療難治性癲癇的臨床證據_《中國循證醫學雜志》

作者：

張鉥纓 , 鄒曉毅

四川大學華西醫院神經內科, 成都 610041　;

關鍵詞：

托吡酯癲癇療效安全性臨床證據

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為給臨床合理用藥提供最佳證據, 作者對檢索Cochrane圖書館(2005年第3期)、MEDLINE(1996～2005)、中文生物醫學期刊文獻數據庫(1996～2005)、中文科技期刊數據庫(1996～2005)及中國期刊全文數據庫(1996～2005)進行了檢索,從符合標準的文獻中篩選高質量的文獻進行評估,以了解托吡酯治療各型難治性癲癇的療效和安全性.最終納入系統評價、Meta分析和隨機對照試驗共11篇.所納入文獻均為A級證據.結果顯示, 托吡酯輔助治療各種類型的難治性癲癇,尤其是難治性部分發作性癲癇療效肯定,耐受性良好,與傳統抗癲癇藥之間無相互作用,具有較大臨床應用價值.其初始劑量為 200 mg/d, 長期維持劑量為400～600mg/d,不推薦使用600 mg/d以上劑量.

引用本文： 張鉥纓,鄒曉毅. 托吡酯治療難治性癲癇的臨床證據. 中國循證醫學雜志, 2006, 06(2): 142-145. doi: 復制

1.	Manish PB,Anita G,Michael G,et al.Clinical experience with topiramate.Epilepsia,2002; 43(Suppl 7):198-199.
2.	Hou XZ.Neurology.The 3th Edition.Beijing:The People’s Press; 1996.175-179.侯熙照.神經病學.第3版.北京:人民衛生出版社; 1996.175～179.
3.	Bob Phillips,Chris Ball,Dave Sackett,et al.Levels of Evidence and Grades.Recommendation.Oxford Centre for Evidence-based Medicine Levels of Evidence,May 2001.
4.	Elterman RD,Glauser TA,Wyllie R,et al.A double-blind randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children.Neurology,1999; 52(7):1338-1344.
5.	Privitera M,Fincham R,Penry,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-、800-and 1000-mg daily dosages.Neurology,1996; 46(6):1678-1683.
6.	Faught E,Wilder BJ,Ramsay RE,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-、400-and 600-mg daily dosages.Neurology,1996; 46(6):1684-1690.
7.	Jakob C,Frederik A,Pouls JH,et al.Randomized,concentration controlled trial of topiramate in refractory focal epilepsy.Neurology,2003; 61(9):1210-1218.
8.	Yen DJ,Yu HY,Guo YC,et al.A double-blind,placebo-controlled study of topiramate in adult patients with refractory partial epilepsy.Epilepsia,2000; 41(9):1162-1166.
9.	Lee B-1,Kim W-J,Kim D-K,et al.Topiramate in medically intractable partial epilepsies:Double-blind,placebo-controlled randomized parallel group trial.Epilepsia,1999; 40(12):1767-1774.
10.	Sharief M,Viteri C,Ben-Menachem E,et al.Double-blind,placebo-controlled study of topiramate in patients with refractory partial epilepsy.Epilepsy research,1996; 25(3):217-214.
11.	Tassinari CA,Michelucci R,Chauvel P,et al.Double-blind,placebo-controlled trial of topiramate (600mg daily)for treatment of refractory partial epilepsy.Epilepsia,1996; 37(8):763-768.
12.	Jette NJ,Marson AG,Hutton JL.Topiramate add-on for drug-resistant partial epilepsy[M/CD].The Cochrane Database of Systematic Reviews 2002,Issue 3.Art.No:CD001417.DOI:10.1002/14651858.CD001417.
13.	Reife RA,Pledger GW.Topiramate as adjunctive therapy in refractory partial epilepsy:pooled analysis of data from five double-blind,placebo-controlled trials.Epilepsia,1997; 138(suppl1):S31-33.
14.	Zheng LZ,Zhang HJ,Song XX.Topiramate in intractable epilepsy:A meta-analysis.Journal of Medical Reaserch,2005; 34(2):30-32.鄭乃智,張慧娟,宋旭霞.托吡酯添加治療難治性癲癇Meta分析.醫學研究通訊,2005; 34(2):30～32.
15.	Lesaffre E,Boon P,Pledger GW.The value of the number-needed-to-treat method in antiepileptic drug trials.Epilepsia,2002; 41(4):440-446.

1. Manish PB,Anita G,Michael G,et al.Clinical experience with topiramate.Epilepsia,2002; 43(Suppl 7):198-199.
2. Hou XZ.Neurology.The 3th Edition.Beijing:The People’s Press; 1996.175-179.侯熙照.神經病學.第3版.北京:人民衛生出版社; 1996.175～179.
3. Bob Phillips,Chris Ball,Dave Sackett,et al.Levels of Evidence and Grades.Recommendation.Oxford Centre for Evidence-based Medicine Levels of Evidence,May 2001.
4. Elterman RD,Glauser TA,Wyllie R,et al.A double-blind randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children.Neurology,1999; 52(7):1338-1344.
5. Privitera M,Fincham R,Penry,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-、800-and 1000-mg daily dosages.Neurology,1996; 46(6):1678-1683.
6. Faught E,Wilder BJ,Ramsay RE,et al.Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-、400-and 600-mg daily dosages.Neurology,1996; 46(6):1684-1690.
7. Jakob C,Frederik A,Pouls JH,et al.Randomized,concentration controlled trial of topiramate in refractory focal epilepsy.Neurology,2003; 61(9):1210-1218.
8. Yen DJ,Yu HY,Guo YC,et al.A double-blind,placebo-controlled study of topiramate in adult patients with refractory partial epilepsy.Epilepsia,2000; 41(9):1162-1166.
9. Lee B-1,Kim W-J,Kim D-K,et al.Topiramate in medically intractable partial epilepsies:Double-blind,placebo-controlled randomized parallel group trial.Epilepsia,1999; 40(12):1767-1774.
10. Sharief M,Viteri C,Ben-Menachem E,et al.Double-blind,placebo-controlled study of topiramate in patients with refractory partial epilepsy.Epilepsy research,1996; 25(3):217-214.
11. Tassinari CA,Michelucci R,Chauvel P,et al.Double-blind,placebo-controlled trial of topiramate (600mg daily)for treatment of refractory partial epilepsy.Epilepsia,1996; 37(8):763-768.
12. Jette NJ,Marson AG,Hutton JL.Topiramate add-on for drug-resistant partial epilepsy[M/CD].The Cochrane Database of Systematic Reviews 2002,Issue 3.Art.No:CD001417.DOI:10.1002/14651858.CD001417.
13. Reife RA,Pledger GW.Topiramate as adjunctive therapy in refractory partial epilepsy:pooled analysis of data from five double-blind,placebo-controlled trials.Epilepsia,1997; 138(suppl1):S31-33.
14. Zheng LZ,Zhang HJ,Song XX.Topiramate in intractable epilepsy:A meta-analysis.Journal of Medical Reaserch,2005; 34(2):30-32.鄭乃智,張慧娟,宋旭霞.托吡酯添加治療難治性癲癇Meta分析.醫學研究通訊,2005; 34(2):30～32.
15. Lesaffre E,Boon P,Pledger GW.The value of the number-needed-to-treat method in antiepileptic drug trials.Epilepsia,2002; 41(4):440-446.

《中國循證醫學雜志》

托吡酯治療難治性癲癇的臨床證據

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《中國循證醫學雜志》

托吡酯治療難治性癲癇的臨床證據

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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