Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer_Chinese Journal of Evidence-Based Medicine

Authors：

TIAN Wenjing ¹ ,  WANG Binyou ¹ , ZHANG Jianzhong ² , ZHAO Jingbo ¹

1. Public Health School, Harbin Medical University, Harbin 150001, China2. Department of Diagnosis, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;

Corresponding?author：

WANG Binyou, Email: zhangjianzhong@icdc.cn

Keywords：

Helicobacter pylori; Gastric cancer; Meta analysis

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Objective 　To analyze the relationship between helicobacter pylori (HP) and gastric cancer.
Methods 　We searched CNKI (Jan.1995-Dec.2005) and Wangfandatabase (Jan.1995-Dec.2005). Case-control studies on relationship of helicobacter pylori infection and gastric cancer were collected. Meta-analysis method was used to sum up the odds ratio (OR) and 95%CI of these studies.
Results 　We identified 14 case-control studies with 11 studies of healthy adults versus gastric cancer patients and 4 studies of gastritis versus gastric cancer patients. The results of subgroup analyses based on patients resource showed: statistical difference was founded between healthy adults and gastric cancer patients with pooled OR 2.00 and 95%CI 1.25 to 3.20; no statistical difference was founded between gastritis patients and gastric cancer patients with pooled OR 1.54 and 95%CI 0.68 to 3.50. The results of subgroup analyses based on locations of gastric cancer showed: statistical difference was founded between the non-cardiac gastric cancer patients and the control with pooled OR 3.60 and 95%CI 1.25 to 10.36; no statistical difference was found between cardiac gastric cancer patients and control with pooled OR 0.88 and 95%CI 0.56 to 1.39.
Conclusion 　HP infection can be associated with gastric cancer, and the different conclusions of the 14 reports may be attributed to the locations of gastric cancer and the selection of controls.

Citation： TIAN Wenjing,WANG Binyou,ZHANG Jianzhong,ZHAO Jingbo. Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer. Chinese Journal of Evidence-Based Medicine, 2006, 06(11): 833-838. doi: Copy

1.	孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20年變化情況分析及其發展趨勢預測. 中華腫瘤雜志, 2004; 26(1): 4~9.
2.	李春, 夏冰, 楊藝, 等. TNF基因多態性與胃十二指腸疾病幽門螺桿菌感染的相關性研究. 中國免疫學雜志, 2005; 21(11): 860~863.
3.	吳炎, 張萬岱, 楊海濤, 等. 幽門螺桿菌感染與胃癌部位組織類型的關系. 世界華人消化雜志, 1997; 5(8): 524~525.
4.	李東光, 高艷紅, 關宏偉, 等. 幽門螺桿菌感染及其他因素在彌散型和腸型胃癌發病中的意義. 中華流行病學雜志, 1995; 16(5): 299~302.
5.	徐世平, 王孟薇, 尤緯締. 幽門螺桿菌感染與人胃癌相關性研究. 中華消化雜志, 1997; 17(4): 211~212.
6.	孫潔, 鄧長生, 黃梅芳. 幽門螺桿菌感染與胃癌的關系研究. 醫學新知雜志, 1998; 8(1): 8~10.
7.	姚文慶, 逯曉波, 等. 沈陽地區胃癌血清標記物病例對照研究. 中國腫瘤, 2000; 9(6): 281~283.
8.	丁建華, 李蘇平, 吳建, 等. 幽門螺桿菌與其它危險因素交互作用致胃癌關系的研究. 中國腫瘤, 2002; 11(5): 267~269.
9.	蘭春慧, 冷恩仁. 幽門螺桿菌感染與胃癌發生的臨床研究. 四川醫學, 2000; 21(1): 22~23.
10.	陳世耀, 王吉耀, 劉天舒. 幽門螺桿菌感染與胃癌 (一項病例對照研究). 胃腸病學和肝病學雜志, 1998; 7(3): 227~229.
11.	楊婕, 胡志斌, 徐耀初, 等. IL-1B及IL-1RN基因多態性與胃癌易感性的關系. 世界華人消化雜志, 2004; 12(8): 1769~1773.
12.	俞順章, 張作風, 俞國培, 等. 飲綠茶對胃癌、慢性胃炎發病影響的流行病學調查. 中國癌癥雜志, 2001; 11(1): 41~45.
13.	李忠佑, 高長明, 丁建華, 等. 上消化道癌及親屬中幽門螺桿菌感染的流行病學調查. 中華流行病學雜志, 1999; 20(2): 88~90.
14.	蔡琳, 俞順章, 張作風. 幽門螺桿菌感染與胃癌的關系. 腫瘤防治研究, 1999; 26(4): 247~249.
15.	蔣詠文, 王潤田, 王濤, 等. 幽門螺桿菌感染與胃癌及胃部病變的多組病例對照研究. 北京大學學報 (醫學版), 2001; 33(2): 160~163.
16.	方積乾. 衛生統計學. 第5版. 北京: 人民衛生出版社; 2000. 399~416.
17.	Marshall BJ, Warren JR . Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984; 1(8390): 1311–1315.
18.	Xia HHX, Wong BCY, Lam SK. Helicobacter pylori infection and gastric cancer. Asian J Surg, 2001; 24: 217–222.
19.	Wong, Shiu Kum Lam, Wai ManWong, et al. Helicobacter pylori eradication to prevent gastric cancer in a high region of China.JAMA, 2004; 291: 187–194.
20.	Pakin DM, Bray F, Ferlay J, et al. Estimating the world cancerburden: Globocan 2000. Int J cancer, 2001; 94(2): 153–156.
21.	Sun XD, Mu R, Zhou YS, et al. Analysis of mortality rate of stomach cancer and its trend in twenty years in China. Chinese Journal of Cancer Prevention and Treatment, 2004; 26(1): 4–9.
22.	Li C, Xia B, Yang Y, et al. Association of TNF gene polymorphism with Helicobacter pylori infection in Chinese patients with gastroduodenal diseases. Chinese Journal of Immunology, 2005; 21(11): 860–863.
23.	Wu Y, Zhang WD, Yang HT, et al. Relationship between HP infection and the locations and histological types of gastric carcinoma. World Chinese Journal of Digestology, 1997; 5(8): 524–525.
24.	Li DG, Gao YH, Guan HW, et al. Helicobacter pylori infection and other factors in diffuse-and intestinal type stomach carcinomas. Chinese Journal of Epidemiology, 1995; 16(5): 299–302.
25.	Xu SP, Wang MW, You WD. Study on the association between Helicobacter pylori infection and human gastric cancer. Chinese Journal of Digestion, 1997; 17(4): 211–212.
26.	Sun J, Deng CS, Huang MF. Study on Relationship between Helicobacterium pylori infection and gastric cancer. Journal of New Medicine, 1998; 8(1): 8–10.
27.	Yao WQ, Lu XB, et al. A serological case-control study of gastric cancer in Shenyang area. Bulletin of Chinese Cancer, 2000; 9(6): 281–283.
28.	Ding JH, Li SP, Wu J, et al. A study on the interactions between Helicobacter pylori and other risk factors for gastric cancer. Bulletin of Chinese Cancer, 2002; 11(5): 267–269.
29.	Lan CH, Leng ER. Clinical research on occurrence of gastric cancer and infection of helicobacter pylori. Sichuan Medical Journal, 2000; 21(1): 22–23.
30.	Chen SY, Wang JY, Liu TS. The relationship between Helicobacter pylori infection and gastric cancer: A case-control study. Chinese Journal of Gastroenterology and Hepatology, 1998; 7(3): 227–229.
31.	Yang J, Hu ZW, Xu YC, et al. Relationship between polymorphisms interleukin-1B-31 and interleukin-1 receptor antagonist gene and susceptibility to gastric cancer. Chinese Journal of Digestology, 2004; 12(8): 1769–1773.
32.	Yu SZ, Zhang ZF, Yu GP, et al. Epidemiological study of the influence of drinking green tea on gastric cancer and chronic gastritis incidence. China Oncology, 2001; 11(1): 41–45.
33.	Li ZY, Gao CM, Ding JH, et al. Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds. Chinese Journal of Epidemiology, 1999; 20(2): 88–90.
34.	Cai L, Yu SZ, Zhang ZF. Relationship between Helicobacter pylori infection and gastric cancer. Cancer Research on Prevention and Treatment, 1999; 26(4): 247–249.
35.	Jang YW, Wang RT, Wang T, et al. Multi groups controled study on the association of Helicobacter pylori infection with gastric cancer and stomach diseases. Journal of Beijing University (Health Sciences), 2001; 33(2): 160–163.
36.	Fang JQ. Health Statistics. 5th ed. Beijing: People’s Health Publishing House; 2000. 399–416.
37.	Eslick GD, Lim LL, Byles JE, et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol, 1999; 94(9): 2373–2379.
38.	Huang JQ, Sridhar S, Chen Y, et al. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 1998; 114(6): 1169~1179.

1. 孫秀娣, 牧人, 周有尚, 等. 中國胃癌死亡率20年變化情況分析及其發展趨勢預測. 中華腫瘤雜志, 2004; 26(1): 4~9.
2. 李春, 夏冰, 楊藝, 等. TNF基因多態性與胃十二指腸疾病幽門螺桿菌感染的相關性研究. 中國免疫學雜志, 2005; 21(11): 860~863.
3. 吳炎, 張萬岱, 楊海濤, 等. 幽門螺桿菌感染與胃癌部位組織類型的關系. 世界華人消化雜志, 1997; 5(8): 524~525.
4. 李東光, 高艷紅, 關宏偉, 等. 幽門螺桿菌感染及其他因素在彌散型和腸型胃癌發病中的意義. 中華流行病學雜志, 1995; 16(5): 299~302.
5. 徐世平, 王孟薇, 尤緯締. 幽門螺桿菌感染與人胃癌相關性研究. 中華消化雜志, 1997; 17(4): 211~212.
6. 孫潔, 鄧長生, 黃梅芳. 幽門螺桿菌感染與胃癌的關系研究. 醫學新知雜志, 1998; 8(1): 8~10.
7. 姚文慶, 逯曉波, 等. 沈陽地區胃癌血清標記物病例對照研究. 中國腫瘤, 2000; 9(6): 281~283.
8. 丁建華, 李蘇平, 吳建, 等. 幽門螺桿菌與其它危險因素交互作用致胃癌關系的研究. 中國腫瘤, 2002; 11(5): 267~269.
9. 蘭春慧, 冷恩仁. 幽門螺桿菌感染與胃癌發生的臨床研究. 四川醫學, 2000; 21(1): 22~23.
10. 陳世耀, 王吉耀, 劉天舒. 幽門螺桿菌感染與胃癌 (一項病例對照研究). 胃腸病學和肝病學雜志, 1998; 7(3): 227~229.
11. 楊婕, 胡志斌, 徐耀初, 等. IL-1B及IL-1RN基因多態性與胃癌易感性的關系. 世界華人消化雜志, 2004; 12(8): 1769~1773.
12. 俞順章, 張作風, 俞國培, 等. 飲綠茶對胃癌、慢性胃炎發病影響的流行病學調查. 中國癌癥雜志, 2001; 11(1): 41~45.
13. 李忠佑, 高長明, 丁建華, 等. 上消化道癌及親屬中幽門螺桿菌感染的流行病學調查. 中華流行病學雜志, 1999; 20(2): 88~90.
14. 蔡琳, 俞順章, 張作風. 幽門螺桿菌感染與胃癌的關系. 腫瘤防治研究, 1999; 26(4): 247~249.
15. 蔣詠文, 王潤田, 王濤, 等. 幽門螺桿菌感染與胃癌及胃部病變的多組病例對照研究. 北京大學學報 (醫學版), 2001; 33(2): 160~163.
16. 方積乾. 衛生統計學. 第5版. 北京: 人民衛生出版社; 2000. 399~416.
17. Marshall BJ, Warren JR . Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet, 1984; 1(8390): 1311–1315.
18. Xia HHX, Wong BCY, Lam SK. Helicobacter pylori infection and gastric cancer. Asian J Surg, 2001; 24: 217–222.
19. Wong, Shiu Kum Lam, Wai ManWong, et al. Helicobacter pylori eradication to prevent gastric cancer in a high region of China.JAMA, 2004; 291: 187–194.
20. Pakin DM, Bray F, Ferlay J, et al. Estimating the world cancerburden: Globocan 2000. Int J cancer, 2001; 94(2): 153–156.
21. Sun XD, Mu R, Zhou YS, et al. Analysis of mortality rate of stomach cancer and its trend in twenty years in China. Chinese Journal of Cancer Prevention and Treatment, 2004; 26(1): 4–9.
22. Li C, Xia B, Yang Y, et al. Association of TNF gene polymorphism with Helicobacter pylori infection in Chinese patients with gastroduodenal diseases. Chinese Journal of Immunology, 2005; 21(11): 860–863.
23. Wu Y, Zhang WD, Yang HT, et al. Relationship between HP infection and the locations and histological types of gastric carcinoma. World Chinese Journal of Digestology, 1997; 5(8): 524–525.
24. Li DG, Gao YH, Guan HW, et al. Helicobacter pylori infection and other factors in diffuse-and intestinal type stomach carcinomas. Chinese Journal of Epidemiology, 1995; 16(5): 299–302.
25. Xu SP, Wang MW, You WD. Study on the association between Helicobacter pylori infection and human gastric cancer. Chinese Journal of Digestion, 1997; 17(4): 211–212.
26. Sun J, Deng CS, Huang MF. Study on Relationship between Helicobacterium pylori infection and gastric cancer. Journal of New Medicine, 1998; 8(1): 8–10.
27. Yao WQ, Lu XB, et al. A serological case-control study of gastric cancer in Shenyang area. Bulletin of Chinese Cancer, 2000; 9(6): 281–283.
28. Ding JH, Li SP, Wu J, et al. A study on the interactions between Helicobacter pylori and other risk factors for gastric cancer. Bulletin of Chinese Cancer, 2002; 11(5): 267–269.
29. Lan CH, Leng ER. Clinical research on occurrence of gastric cancer and infection of helicobacter pylori. Sichuan Medical Journal, 2000; 21(1): 22–23.
30. Chen SY, Wang JY, Liu TS. The relationship between Helicobacter pylori infection and gastric cancer: A case-control study. Chinese Journal of Gastroenterology and Hepatology, 1998; 7(3): 227–229.
31. Yang J, Hu ZW, Xu YC, et al. Relationship between polymorphisms interleukin-1B-31 and interleukin-1 receptor antagonist gene and susceptibility to gastric cancer. Chinese Journal of Digestology, 2004; 12(8): 1769–1773.
32. Yu SZ, Zhang ZF, Yu GP, et al. Epidemiological study of the influence of drinking green tea on gastric cancer and chronic gastritis incidence. China Oncology, 2001; 11(1): 41–45.
33. Li ZY, Gao CM, Ding JH, et al. Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds. Chinese Journal of Epidemiology, 1999; 20(2): 88–90.
34. Cai L, Yu SZ, Zhang ZF. Relationship between Helicobacter pylori infection and gastric cancer. Cancer Research on Prevention and Treatment, 1999; 26(4): 247–249.
35. Jang YW, Wang RT, Wang T, et al. Multi groups controled study on the association of Helicobacter pylori infection with gastric cancer and stomach diseases. Journal of Beijing University (Health Sciences), 2001; 33(2): 160–163.
36. Fang JQ. Health Statistics. 5th ed. Beijing: People’s Health Publishing House; 2000. 399–416.
37. Eslick GD, Lim LL, Byles JE, et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol, 1999; 94(9): 2373–2379.
38. Huang JQ, Sridhar S, Chen Y, et al. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 1998; 114(6): 1169~1179.

Chinese Journal of Evidence-Based Medicine

Meta-analysis on Relationship Between Helicobacter Pylori Infection and Gastric Cancer

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