主動脈彈力纖維的修復策略_《中國修復重建外科雜志》

作者：

衛任 , 熊江 , 郭偉

解放軍總醫院血管外科（北京，100853）;

關鍵詞：

主動脈動脈瘤彈力纖維彈力蛋白修復

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的對主動脈彈力纖維修復的研究策略進行綜述。方法查閱國內外關于彈力纖維及其修復的
文獻，圍繞促進各組成蛋白合成、改善組裝條件和減少危險因子破壞3 方面進行綜述。結果促進蛋白合成方面，以彈
力蛋白的促表達研究較多，方法分別有基因轉染、外源性因子刺激及誘導平滑肌表型轉變；fibulin 與賴氨酰氧化酶類有
助于彈力纖維的組裝，但其機制尚不明確；減少危險因子的破壞主要圍繞抑制基質金屬蛋白酶類的表達及其作用效應展
開。結論主動脈彈力纖維的高質量修復，需保證其各組成蛋白的充足合成、有效組裝并減少危險因子的破壞。

引用本文： 衛任,熊江,郭偉. 主動脈彈力纖維的修復策略. 中國修復重建外科雜志, 2012, 26(5): 621-624. doi: 復制

1.	Waterhouse A, Wise SG, Ng MK, et al. Elastin as a nonthrombogenic biomaterial. Tissue Eng Part B Rev, 2011, 17(2): 93-99.
2.	Robert L. Cell-elastin interaction and signaling. Pathol Biol (Paris), 2005, 53(7): 399-404.
3.	Rosenbloom J, Abrams WR, Mecham R. Extracellular matrix 4: the elastic fiber. FASEB J, 1993, 7(13): 1208-1218.
4.	Wagenseil JE, Mecham RP. New insights into elastic fiber assembly. Birth Defects Res C Embryo Today, 2007, 81(4): 229-240.
5.	Muiznieks LD, Weiss AS, FW Keeley. Structural disorder and dynamics of elastin. Biochem Cell Biol, 2010, 88(2): 239-250.
6.	Sherratt MJ. Tissue elasticity and the ageing elastic fibre. AGE (Dordr), 2009, 31(4): 305-325.
7.	Cirulis JT, Bellingham CM, Davis EC, et al. Fibrillins, fibulin, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry, 2008, 47(47): 12601-12613.
8.	Patel A, Fine B, Sandig M, et al. Elastin biosynthesis: The missing link in tissue-engineered blood vessels. Cardiovasc Res, 2006, 71(1): 40-49.
9.	Xiong J, Wang SM, Chen LH, et al. Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and testedin the elastase model of abdominal aortic aneurysm in rats. J Vasc Surg, 2008, 48(4): 965-973.
10.	Srisuma S, Bhattacharya S, Simon DM, et al. Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis. Am J Respir Crit Care Med, 2010, 181(8): 838-850.
11.	Kothapalli CR, Taylor PM, Smolenski RT, et al. Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells. Tissue Eng Part A, 2009, 15(3): 501-511.
12.	Mecham RP, Levy BD, Morris SL, et al. Increased cyclic GMP levels lead to a stimulation of elastin production in ligament fibroblasts that is reversed by cyclic AMP. J Biol Chem, 1985, 260(6): 3255-3258.
13.	Joddar B, Ramamurthi A. Elastogenic effects of exogenous hyaluronan oligosaccharides on vascular smooth muscle cells. Biomaterials, 2006, 27(33): 5698-5707.
14.	Saitow C, Kaplan DL, Castellot JJ Jr. Heparin stimulates elastogenesis: application to silk-based vascular grafts. Matrix Biol, 2011, 30(5-6): 346-355.
15.	Swee MH, Parks WC, Pierce RA. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem, 1995, 270(25): 14899-14906.
16.	Owens GK. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp, 2007, 283: 174-191.
17.	Lindholt JS, Jørgensen B, Klitgaard NA, et al. Systemic levels of cotinine and elastase but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg, 2003, 26(4): 418-422.
18.	Gacchina C, Brothers T, Ramamurthi A. Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells. Tissue Eng Part A, 2011, 17(15-16): 1945-1958.
19.	Hirai M, Ohbayashi T, Horiguchi M, et al. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol, 2007, 176(7): 1061-1071.
20.	Horiguchi M, Inoue T, Ohbayashi T, et al. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A, 2009, 106(45): 19029-19034.
21.	Noblesse E, Cenizo V, Bouez C, et al. Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers. J Invest Dermatol, 2004, 122(3): 621-630.
22.	Kothapalli CR, Ramamurthi A. Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells. J Tissue Eng Regen Med, 2009, 3(8): 655-6561.
23.	Yanagisawa H, Davis EC, Starcher BC, et al. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature, 2002, 415(6868): 168-171.
24.	Choudhury R, McGovern A, Ridley C, et al. Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem, 2009, 284(36): 24553-24567.
25.	Xie J, Jiang J, Zhang Y, et al. Up-regulation expressions of lysyl oxidase family in Anterior Cruciate Ligament and Medial Collateral Ligament fibroblasts induced by Transforming Growth Factor-Beta 1. Int Orthop, 2012, 36(1): 207-213.
26.	Hirai M, Horiguchi M, Ohbayashi T, et al. Latent TGF-β-binding protein 2 binds to DANCE/?bulin-5 and regulates elastic ?ber assembly. EMBO J, 2007, 26(14): 3283-3295.
27.	Mata KM, Prudente PS, Rocha FS, et al. Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model. Int J Exp Pathol, 2011, 92(1): 26-39.
28.	Abdul-Hussien H, Hanemaaijer R, Verheijen JH, et al. Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content. J Vasc Surg, 2009, 49(3): 741-749.
29.	Baxter BT, Terrin MC, Dalman RL. Medical management of small abdominal aortic aneurysms. Circulation, 2008, 117(14): 1883-1889.
30.	Shiraya S, Miyake T, Aoki M, et al. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis, 2009, 202(1): 34-40.
31.	Evans J, Powell JT, Schwalbe E, et al. Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg, 2007, 34(3): 302-303.
32.	Chuang SY, Yang SH, Chen TY, et al. Cilostazol inhibits matrix invasion and modulates the gene expressions of MMP-9 and TIMP-1 in PMA-differentiated THP-1 cells. Eur J Pharmacol, 2011, 670(2-3): 419-426.
33.	Ikonomidia JS, Gibson WC, Butler JE, et al. Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms. Circulation, 2004, 110(11 suppl 1): II268-273.
34.	Allaire E, Forough R, Clowes M, et al. Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest, 1998, 102(7): 1413-1420.
35.	趙新, 張培瑞, 俞祥海, 等. 腺病毒介導TIMP-2基因轉染抑制大鼠腹主動脈細胞外基質降解的實驗研究. 中國普外基礎與臨床雜志, 2007, 14(3): 276-279.
36.	Bond M, Chase AJ, Baker AH, et al. Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res, 2001, 50(3): 556-565.
37.	Parodi PE, Mao D, Ennis TL, et al. Suppression of wxperimental abdominal aortic aneurysms in mice by treatment with pyrrolidene dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J Vasc Surg, 2005, 41(3): 479-489.
38.	Lawrence DM, Singh RS, Franklin DP, et al. Rapamycin suppresses experimental aortic aneurysm growth. J Vasc Surg, 2004, 40(2): 334-338.
39.	Yoshimura K, Aoki H, Ikeda Y, et al. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci, 2006, 1085: 74-81.
40.	McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol, 2007, 27(3): 461-469.
41.	Morimoto K, Hasegawa T, Tanaka A, et al. Free radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats. J Vasc Surg, 2012. [Epub ahead of print].
42.	Chuang TH, Stabler C, Simionescu A, et al. Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng Part A, 2009, 15(10): 2837-2851.
43.	Isenburg JC, Simionescu DT, Starcher BC, et al. Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation, 2007, 115(13): 1729-1737.

1. Waterhouse A, Wise SG, Ng MK, et al. Elastin as a nonthrombogenic biomaterial. Tissue Eng Part B Rev, 2011, 17(2): 93-99.
2. Robert L. Cell-elastin interaction and signaling. Pathol Biol (Paris), 2005, 53(7): 399-404.
3. Rosenbloom J, Abrams WR, Mecham R. Extracellular matrix 4: the elastic fiber. FASEB J, 1993, 7(13): 1208-1218.
4. Wagenseil JE, Mecham RP. New insights into elastic fiber assembly. Birth Defects Res C Embryo Today, 2007, 81(4): 229-240.
5. Muiznieks LD, Weiss AS, FW Keeley. Structural disorder and dynamics of elastin. Biochem Cell Biol, 2010, 88(2): 239-250.
6. Sherratt MJ. Tissue elasticity and the ageing elastic fibre. AGE (Dordr), 2009, 31(4): 305-325.
7. Cirulis JT, Bellingham CM, Davis EC, et al. Fibrillins, fibulin, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry, 2008, 47(47): 12601-12613.
8. Patel A, Fine B, Sandig M, et al. Elastin biosynthesis: The missing link in tissue-engineered blood vessels. Cardiovasc Res, 2006, 71(1): 40-49.
9. Xiong J, Wang SM, Chen LH, et al. Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and testedin the elastase model of abdominal aortic aneurysm in rats. J Vasc Surg, 2008, 48(4): 965-973.
10. Srisuma S, Bhattacharya S, Simon DM, et al. Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis. Am J Respir Crit Care Med, 2010, 181(8): 838-850.
11. Kothapalli CR, Taylor PM, Smolenski RT, et al. Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells. Tissue Eng Part A, 2009, 15(3): 501-511.
12. Mecham RP, Levy BD, Morris SL, et al. Increased cyclic GMP levels lead to a stimulation of elastin production in ligament fibroblasts that is reversed by cyclic AMP. J Biol Chem, 1985, 260(6): 3255-3258.
13. Joddar B, Ramamurthi A. Elastogenic effects of exogenous hyaluronan oligosaccharides on vascular smooth muscle cells. Biomaterials, 2006, 27(33): 5698-5707.
14. Saitow C, Kaplan DL, Castellot JJ Jr. Heparin stimulates elastogenesis: application to silk-based vascular grafts. Matrix Biol, 2011, 30(5-6): 346-355.
15. Swee MH, Parks WC, Pierce RA. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem, 1995, 270(25): 14899-14906.
16. Owens GK. Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp, 2007, 283: 174-191.
17. Lindholt JS, Jørgensen B, Klitgaard NA, et al. Systemic levels of cotinine and elastase but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg, 2003, 26(4): 418-422.
18. Gacchina C, Brothers T, Ramamurthi A. Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells. Tissue Eng Part A, 2011, 17(15-16): 1945-1958.
19. Hirai M, Ohbayashi T, Horiguchi M, et al. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol, 2007, 176(7): 1061-1071.
20. Horiguchi M, Inoue T, Ohbayashi T, et al. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A, 2009, 106(45): 19029-19034.
21. Noblesse E, Cenizo V, Bouez C, et al. Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers. J Invest Dermatol, 2004, 122(3): 621-630.
22. Kothapalli CR, Ramamurthi A. Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells. J Tissue Eng Regen Med, 2009, 3(8): 655-6561.
23. Yanagisawa H, Davis EC, Starcher BC, et al. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature, 2002, 415(6868): 168-171.
24. Choudhury R, McGovern A, Ridley C, et al. Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem, 2009, 284(36): 24553-24567.
25. Xie J, Jiang J, Zhang Y, et al. Up-regulation expressions of lysyl oxidase family in Anterior Cruciate Ligament and Medial Collateral Ligament fibroblasts induced by Transforming Growth Factor-Beta 1. Int Orthop, 2012, 36(1): 207-213.
26. Hirai M, Horiguchi M, Ohbayashi T, et al. Latent TGF-β-binding protein 2 binds to DANCE/?bulin-5 and regulates elastic ?ber assembly. EMBO J, 2007, 26(14): 3283-3295.
27. Mata KM, Prudente PS, Rocha FS, et al. Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model. Int J Exp Pathol, 2011, 92(1): 26-39.
28. Abdul-Hussien H, Hanemaaijer R, Verheijen JH, et al. Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content. J Vasc Surg, 2009, 49(3): 741-749.
29. Baxter BT, Terrin MC, Dalman RL. Medical management of small abdominal aortic aneurysms. Circulation, 2008, 117(14): 1883-1889.
30. Shiraya S, Miyake T, Aoki M, et al. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Atherosclerosis, 2009, 202(1): 34-40.
31. Evans J, Powell JT, Schwalbe E, et al. Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue. Eur J Vasc Endovasc Surg, 2007, 34(3): 302-303.
32. Chuang SY, Yang SH, Chen TY, et al. Cilostazol inhibits matrix invasion and modulates the gene expressions of MMP-9 and TIMP-1 in PMA-differentiated THP-1 cells. Eur J Pharmacol, 2011, 670(2-3): 419-426.
33. Ikonomidia JS, Gibson WC, Butler JE, et al. Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms. Circulation, 2004, 110(11 suppl 1): II268-273.
34. Allaire E, Forough R, Clowes M, et al. Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest, 1998, 102(7): 1413-1420.
35. 趙新, 張培瑞, 俞祥海, 等. 腺病毒介導TIMP-2基因轉染抑制大鼠腹主動脈細胞外基質降解的實驗研究. 中國普外基礎與臨床雜志, 2007, 14(3): 276-279.
36. Bond M, Chase AJ, Baker AH, et al. Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res, 2001, 50(3): 556-565.
37. Parodi PE, Mao D, Ennis TL, et al. Suppression of wxperimental abdominal aortic aneurysms in mice by treatment with pyrrolidene dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J Vasc Surg, 2005, 41(3): 479-489.
38. Lawrence DM, Singh RS, Franklin DP, et al. Rapamycin suppresses experimental aortic aneurysm growth. J Vasc Surg, 2004, 40(2): 334-338.
39. Yoshimura K, Aoki H, Ikeda Y, et al. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci, 2006, 1085: 74-81.
40. McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol, 2007, 27(3): 461-469.
41. Morimoto K, Hasegawa T, Tanaka A, et al. Free radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats. J Vasc Surg, 2012. [Epub ahead of print].
42. Chuang TH, Stabler C, Simionescu A, et al. Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng Part A, 2009, 15(10): 2837-2851.
43. Isenburg JC, Simionescu DT, Starcher BC, et al. Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation, 2007, 115(13): 1729-1737.

《中國修復重建外科雜志》

主動脈彈力纖維的修復策略

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國修復重建外科雜志》

主動脈彈力纖維的修復策略

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料