神經干細胞與BMSCs 移植治療脊髓損傷的研究進展_《中國修復重建外科雜志》

作者：

許朝進

溫州醫學院組織胚胎學教研室（浙江溫州，325035）;

關鍵詞：

神經干細胞 BMSCs 免疫學特性脊髓損傷細胞移植

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】目的綜述神經干細胞（neural stem cells，NSCs）與BMSCs 的免疫學特性及治療脊髓損傷（spinal cord
injury，SCI）的新進展。方法廣泛查閱近年國內外相關文獻，對NSCs 與BMSCs 的免疫學特性、移植治療SCI 的實驗
研究與可能存在的問題進行分析。結果動物實驗表明NSCs 與BMSCs 移植可促進SCI 動物行為學改善，但由于兩
種干細胞的免疫學特性，同種異體干細胞移植后將產生免疫排斥反應。結論 NSCs 與BMSCs 對SCI 有很好的治療效
果，但是免疫排斥問題值得考慮。

引用本文： 許朝進. 神經干細胞與BMSCs 移植治療脊髓損傷的研究進展. 中國修復重建外科雜志, 2012, 26(2): 186-189. doi: 復制

1.	Webber DJ, Bradbury EJ, McMahon SB, et al. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med, 2007, 2 (6): 929-945.
2.	Xu CJ, Xu L, Huang LD, et al. Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. Neuropathol Appl Neurobiol, 2011, 37(2): 135-155.
3.	Xu L, Xu C, Lü HZ, et al. Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord. Stem Cell Rev, 2010, 6 (1): 121-136.
4.	Cummings BJ, Uchida N, Tamaki SJ, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A, 2005, 102 (39): 14069-14074.
5.	Salazar DL, Uchida N, Hamers FP, et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One, 2010, 5(8): 15.
6.	Shihabuddin LS, Horner PJ, Ray J, et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci, 2000, 20 (23): 8727-8735.
7.	Karimi-Abdolrezaee S, Eftekharpour E, Wang J, et al. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci, 2006, 26 (13): 3377-3389.
8.	Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord stem/progenitor cells for spinal cord injury. J Neurotrauma, 2007, 24 (5): 835-845.
9.	Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A, 2004, 101 (52): 18117-18122.
10.	Kimura A, Ohmori T, Ohkawa R, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells, 2007, 25(1): 115-124.
11.	Al Nimer F, Wennersten A, Holmin S, et al. MHC expression after human neural stem cell transplantation to brain contused rats. Neuroreport, 2004, 15 (12): 1871-1875.
12.	Yin L, Fu SL, Shi GY, et al. Expression and regulation of major histocompatibility complex on neural stem cells and their lineages. Stem Cells Dev, 2008, 17 (1): 53-65.
13.	Pluchino S, Gritti A, Blezer E, et al. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol, 2009, 66(3): 343-354.
14.	Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci, 2008, 265(1-2): 102-104.
15.	Lee JM, Yan P, Xiao Q, et al. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci, 2008, 28(12): 3141-3149.
16.	Miller RH, Bai L, Lennon DP, et al. The potential of mesenchymal stem cells for neural repair. Discov Med, 2010, 9(46): 236-242.
17.	Sheth RN, Manzano G, Li X, et al. Transplantation of human bone marrow-derived stromal cells into the contused spinal cord of nude rats. J Neurosurg Spine, 2008, 8(2): 153-162.
18.	Kim KN, Oh SH, Lee KH, et al. Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord. Acta Neurochir Suppl, 2006, 99(1): 133-136.
19.	Nandoe Tewarie RD, Hurtado A, Ritfeld GJ, et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma, 2009, 26(12): 2313-2322.
20.	Cizkova D, Novotna I, Slovinska L, et al. Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J Neurotrauma, 2011, 28(9): 1951-1961.
21.	Vaquero J, Zurita M. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol, 2009, 24 (1): 107-116.
22.	Koda M, Okada S, Nakayama T, et al. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. NeuroReport, 2005, 16 (16): 1763-1767.
23.	Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood, 2007, 110 (10): 3499-3506.
24.	Dupuis L, Pehar M, Cassina P, et al. Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A, 2008, 105 (2): 740-745.
25.	Lee WS, Suzuki Y, Graves SS, et al. Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant, 2011, 17 (4): 465-475.
26.	Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 2005, 106(5): 1755-1761.
27.	Chung YC, Ma MC, Huang BY, et al. Protection of bone marrow-derived CD45+/CD34-/lin- stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats. Chin J Physiol, 2011, 54(3): 169-182.
28.	Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol, 2007, 61(3): 219-227.

1. Webber DJ, Bradbury EJ, McMahon SB, et al. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med, 2007, 2 (6): 929-945.
2. Xu CJ, Xu L, Huang LD, et al. Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. Neuropathol Appl Neurobiol, 2011, 37(2): 135-155.
3. Xu L, Xu C, Lü HZ, et al. Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord. Stem Cell Rev, 2010, 6 (1): 121-136.
4. Cummings BJ, Uchida N, Tamaki SJ, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A, 2005, 102 (39): 14069-14074.
5. Salazar DL, Uchida N, Hamers FP, et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One, 2010, 5(8): 15.
6. Shihabuddin LS, Horner PJ, Ray J, et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci, 2000, 20 (23): 8727-8735.
7. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, et al. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci, 2006, 26 (13): 3377-3389.
8. Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord stem/progenitor cells for spinal cord injury. J Neurotrauma, 2007, 24 (5): 835-845.
9. Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A, 2004, 101 (52): 18117-18122.
10. Kimura A, Ohmori T, Ohkawa R, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells, 2007, 25(1): 115-124.
11. Al Nimer F, Wennersten A, Holmin S, et al. MHC expression after human neural stem cell transplantation to brain contused rats. Neuroreport, 2004, 15 (12): 1871-1875.
12. Yin L, Fu SL, Shi GY, et al. Expression and regulation of major histocompatibility complex on neural stem cells and their lineages. Stem Cells Dev, 2008, 17 (1): 53-65.
13. Pluchino S, Gritti A, Blezer E, et al. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol, 2009, 66(3): 343-354.
14. Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci, 2008, 265(1-2): 102-104.
15. Lee JM, Yan P, Xiao Q, et al. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci, 2008, 28(12): 3141-3149.
16. Miller RH, Bai L, Lennon DP, et al. The potential of mesenchymal stem cells for neural repair. Discov Med, 2010, 9(46): 236-242.
17. Sheth RN, Manzano G, Li X, et al. Transplantation of human bone marrow-derived stromal cells into the contused spinal cord of nude rats. J Neurosurg Spine, 2008, 8(2): 153-162.
18. Kim KN, Oh SH, Lee KH, et al. Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord. Acta Neurochir Suppl, 2006, 99(1): 133-136.
19. Nandoe Tewarie RD, Hurtado A, Ritfeld GJ, et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma, 2009, 26(12): 2313-2322.
20. Cizkova D, Novotna I, Slovinska L, et al. Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J Neurotrauma, 2011, 28(9): 1951-1961.
21. Vaquero J, Zurita M. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol, 2009, 24 (1): 107-116.
22. Koda M, Okada S, Nakayama T, et al. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. NeuroReport, 2005, 16 (16): 1763-1767.
23. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood, 2007, 110 (10): 3499-3506.
24. Dupuis L, Pehar M, Cassina P, et al. Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A, 2008, 105 (2): 740-745.
25. Lee WS, Suzuki Y, Graves SS, et al. Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant, 2011, 17 (4): 465-475.
26. Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 2005, 106(5): 1755-1761.
27. Chung YC, Ma MC, Huang BY, et al. Protection of bone marrow-derived CD45+/CD34-/lin- stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats. Chin J Physiol, 2011, 54(3): 169-182.
28. Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol, 2007, 61(3): 219-227.

《中國修復重建外科雜志》

神經干細胞與BMSCs 移植治療脊髓損傷的研究進展

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《中國修復重建外科雜志》

神經干細胞與BMSCs 移植治療脊髓損傷的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料