細胞治療策略促進牽張成骨的研究進展_《中國修復重建外科雜志》

作者：

馬東洋 ¹ , 毛天球 ²

1蘭州軍區蘭州總醫院口腔頜面外科（蘭州，730050）;;
2 第四軍醫大學口腔醫學院頜面外科;

關鍵詞：

細胞治療牽張成骨骨再生

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目的綜述細胞治療策略在促進牽張成骨（distraction osteogenesis，DO）方面的研究進展。方法廣泛查閱近年來國內外關于細胞治療策略促進DO、縮短治療周期的研究文獻，對常用方法進行分析總結。結果常用的促進骨再生的細胞治療策略有細胞注射治療、細胞-外源性載體支架復合物/可注射組織工程骨、微組織或多細胞聚集體技術、細胞基因治療，各有優缺點。除自體BMSCs與富血小板血漿復合注射的方法有臨床應用報道外，其他方法仍處于基礎研究階段。結論細胞治療策略在骨再生、促進DO及縮短其治療周期等方面具有廣闊前景，應用于臨床前需嚴謹設計臨床前試驗來評價其安全性并規范應用方法。

引用本文： 馬東洋,毛天球. 細胞治療策略促進牽張成骨的研究進展. 中國修復重建外科雜志, 2012, 26(12): 1512-1515. doi: 復制

1.	Sailhan F. Bone lengthening (distraction osteogenesis): a literature review. Osteoporos Int, 2011, 22(6): 2011-2015.
2.	Sabharwal S. Enhancement of bone formation during distraction osteogenesis: pediatric applications. J Am Acad Orthop Surg, 2011, 19(2): 101-111.
3.	Devine MJ, Mierisch CM, Jang E, et al. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res, 2002, 20(6): 1232-1239.
4.	Granero-Moltó F, Weis JA, Miga MI, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells, 2009, 27(8): 1887-1898.
5.	Hamanishi C, Yoshii T, Totani Y, et al. Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. Clin Orthop Relat Res, 1994, (303): 250-255.
6.	Hernigou P, Poignard A, Beaujean F, et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg (Am), 2005, 87(7): 1430-1437.
7.	Peters A, Toben D, Lienau J, et al. Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing. Tissue Eng Part A, 2009, 15(10): 2947-2954.
8.	Takushima A, Kitano Y, Harii K. Osteogenic potential of cultured periosteal cells in a distracted bone gap in rabbits. J Surg Res, 1998, 78(1): 68-77.
9.	Qi M, Hu J, Zou S, et al. Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg, 2006, 34(5): 283-289.
10.	Shao Z, Liu B, Peng Q, et al. Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible. Plast Reconstr Surg, 2007, 119(2): 500-507.
11.	Takamine Y, Tsuchiya H, Kitakoji T, et al. Distraction osteogenesis enhanced by osteoblastlike cells and collagen gel. Clin Orthop Relat Res, 2002, (399): 240-246.
12.	Dai W, Hale SL, Kay GL, et al. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology. Regen Med, 2009, 4(3): 387-395.
13.	Kinoshita K, Hibi H, Yamada Y, et al. Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material. J Craniofac Surg, 2008, 19(1): 80-87.
14.	Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone, 2007, 40(2): 522-528.
15.	Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials, 2009, 30(28): 4956-4966.
16.	Sands JJ, Nudo SA, Ashford RG, et al. Antibodies to topical bovine thrombin correlate with access thrombosis. Am J Kidney Dis, 2000, 35(5): 796-801.
17.	Bueno EM, Glowacki J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol, 2009, 5(12): 685-697.
18.	Kelm JM, Fussenegger M. Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev, 2010, 62(7-8): 753-764.
19.	Kneser U, Stangenberg L, Ohnolz J, et al. Evaluation of processed bovine cancellous bone matrix seeded with syngenic osteoblasts in a critical size calvarial defect rat model. J Cell Mol Med, 2006, 10(3): 695-707.
20.	Langenbach F, Naujoks C, Smeets R, et al. Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering. Clin Oral Investig, 2012. [Epub ahead of print].
21.	Ma D, Zhong C, Yao H, et al. Engineering injectable bone using bone marrow stromal cell aggregates. Stem Cell Devel, 2011, 20(6): 989-999.
22.	Tseng SS, Lee MA, Reddi AH. Nonunions and the potential of stem cells in fracture-healing. J Bone Joint Surg (Am), 2008, 90 Suppl 1: 92-98.
23.	Hu J, Qi MC, Zou SJ, et al. Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res, 2007, 25(2): 241-251.
24.	Jiang X, Zou S, Ye B, et al. bFGF-Modified BMMSCs enhance bone regeneration following distraction osteogenesis in rabbits. Bone, 2010, 46(4): 1156-1161.

1. Sailhan F. Bone lengthening (distraction osteogenesis): a literature review. Osteoporos Int, 2011, 22(6): 2011-2015.
2. Sabharwal S. Enhancement of bone formation during distraction osteogenesis: pediatric applications. J Am Acad Orthop Surg, 2011, 19(2): 101-111.
3. Devine MJ, Mierisch CM, Jang E, et al. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res, 2002, 20(6): 1232-1239.
4. Granero-Moltó F, Weis JA, Miga MI, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells, 2009, 27(8): 1887-1898.
5. Hamanishi C, Yoshii T, Totani Y, et al. Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. Clin Orthop Relat Res, 1994, (303): 250-255.
6. Hernigou P, Poignard A, Beaujean F, et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg (Am), 2005, 87(7): 1430-1437.
7. Peters A, Toben D, Lienau J, et al. Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing. Tissue Eng Part A, 2009, 15(10): 2947-2954.
8. Takushima A, Kitano Y, Harii K. Osteogenic potential of cultured periosteal cells in a distracted bone gap in rabbits. J Surg Res, 1998, 78(1): 68-77.
9. Qi M, Hu J, Zou S, et al. Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg, 2006, 34(5): 283-289.
10. Shao Z, Liu B, Peng Q, et al. Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible. Plast Reconstr Surg, 2007, 119(2): 500-507.
11. Takamine Y, Tsuchiya H, Kitakoji T, et al. Distraction osteogenesis enhanced by osteoblastlike cells and collagen gel. Clin Orthop Relat Res, 2002, (399): 240-246.
12. Dai W, Hale SL, Kay GL, et al. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology. Regen Med, 2009, 4(3): 387-395.
13. Kinoshita K, Hibi H, Yamada Y, et al. Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material. J Craniofac Surg, 2008, 19(1): 80-87.
14. Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone, 2007, 40(2): 522-528.
15. Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials, 2009, 30(28): 4956-4966.
16. Sands JJ, Nudo SA, Ashford RG, et al. Antibodies to topical bovine thrombin correlate with access thrombosis. Am J Kidney Dis, 2000, 35(5): 796-801.
17. Bueno EM, Glowacki J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol, 2009, 5(12): 685-697.
18. Kelm JM, Fussenegger M. Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev, 2010, 62(7-8): 753-764.
19. Kneser U, Stangenberg L, Ohnolz J, et al. Evaluation of processed bovine cancellous bone matrix seeded with syngenic osteoblasts in a critical size calvarial defect rat model. J Cell Mol Med, 2006, 10(3): 695-707.
20. Langenbach F, Naujoks C, Smeets R, et al. Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering. Clin Oral Investig, 2012. [Epub ahead of print].
21. Ma D, Zhong C, Yao H, et al. Engineering injectable bone using bone marrow stromal cell aggregates. Stem Cell Devel, 2011, 20(6): 989-999.
22. Tseng SS, Lee MA, Reddi AH. Nonunions and the potential of stem cells in fracture-healing. J Bone Joint Surg (Am), 2008, 90 Suppl 1: 92-98.
23. Hu J, Qi MC, Zou SJ, et al. Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res, 2007, 25(2): 241-251.
24. Jiang X, Zou S, Ye B, et al. bFGF-Modified BMMSCs enhance bone regeneration following distraction osteogenesis in rabbits. Bone, 2010, 46(4): 1156-1161.

《中國修復重建外科雜志》

細胞治療策略促進牽張成骨的研究進展

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《中國修復重建外科雜志》

細胞治療策略促進牽張成骨的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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