阿侖膦酸鈉對骨關節炎關節軟骨保護作用的研究進展_《中國修復重建外科雜志》

作者：

何丁文 , 殷明 , 羅元一 , 魏強強

南昌大學第二附屬醫院骨一科（南昌，330006）;

關鍵詞：

骨關節炎阿侖膦酸鈉軟骨保護作用

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目的綜述阿侖膦酸鈉（alendronate，ALN）對骨關節炎（osteoarthritis，OA）關節軟骨保護作用的研究進展。方法廣泛查閱近年國內外相關文獻，并進行綜合分析。結果ALN能改善OA關節軟骨代謝微環境，抑制軟骨下骨骨重塑，對關節軟骨有潛在保護作用。結論ALN有望成為一種OA疾病改善藥物，但OA治療尚缺乏統一的基礎與臨床評價標準，制定統一標準并獲取臨床數據對ALN的開發和應用有指導性意義。

引用本文： 何丁文,殷明,羅元一,魏強強. 阿侖膦酸鈉對骨關節炎關節軟骨保護作用的研究進展. 中國修復重建外科雜志, 2012, 26(10): 1187-1190. doi: 復制

1.	Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
2.	王哲彥, 王文雅, 張柳. 骨性關節炎的發病機制及其與Wnt/β-catenin信號通路的關系. 中國矯形外科雜志, 2009, 17(23): 1800-1803.
3.	Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
4.	Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
5.	Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
6.	Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
7.	Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
8.	胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對軟骨細胞的影響及對兔前交叉韌帶切斷后關節軟骨和軟骨下骨的作用. 中國修復重建外科雜志, 2009, 23(12): 1474-1481.
9.	王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對IL-1β體外誘導培養的大鼠膝關節軟骨細胞影響的實驗研究. 中國修復重建外科雜志, 2011, 25(1): 50-55.
10.	Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
11.	谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對大鼠骨關節炎影響的實驗研究. 武漢大學學報: 醫學版, 2009, 30(1): 66-69.
12.	婁方勇, 衛小春. 阿侖膦酸鈉對骨質疏松大鼠關節軟骨的影響. 中國藥物與臨床, 2009, 9(4): 261-264.
13.	梁祖建, 李釗, 張還添, 等. 福善美調控軟骨下骨骨重塑保護關節軟骨的機制研究. 中國骨質疏松雜志, 2009, 15(3): 206-210.
14.	李強, 張柳, 李震, 等. 阿侖膦酸鈉對前交叉韌帶切斷大鼠關節軟骨退變的影響. 中國矯形外科雜志, 2010, 18(14): 1200-1204.
15.	程潭, 張柳, 李震, 等. 阿侖膦酸鈉對兔膝骨關節炎關節軟骨及軟骨下骨保護的作用. 中國老年學雜志, 2010, 30(24): 3695-3698.
16.	Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
17.	Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
18.	Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
19.	Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
20.	柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯合骨肽注射液治療膝骨性關節炎療效分析. 中國誤診學雜志, 2011, 11(31): 7646-7647.
21.	李亞芹. 針刀松解術聯合阿侖膦酸鈉治療膝關節退行性骨病. 臨床和實驗醫學雜志, 2011, 10(11): 853, 856.
22.	Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.

1. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
2. 王哲彥, 王文雅, 張柳. 骨性關節炎的發病機制及其與Wnt/β-catenin信號通路的關系. 中國矯形外科雜志, 2009, 17(23): 1800-1803.
3. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
4. Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
5. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
6. Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
7. Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
8. 胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對軟骨細胞的影響及對兔前交叉韌帶切斷后關節軟骨和軟骨下骨的作用. 中國修復重建外科雜志, 2009, 23(12): 1474-1481.
9. 王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對IL-1β體外誘導培養的大鼠膝關節軟骨細胞影響的實驗研究. 中國修復重建外科雜志, 2011, 25(1): 50-55.
10. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
11. 谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對大鼠骨關節炎影響的實驗研究. 武漢大學學報: 醫學版, 2009, 30(1): 66-69.
12. 婁方勇, 衛小春. 阿侖膦酸鈉對骨質疏松大鼠關節軟骨的影響. 中國藥物與臨床, 2009, 9(4): 261-264.
13. 梁祖建, 李釗, 張還添, 等. 福善美調控軟骨下骨骨重塑保護關節軟骨的機制研究. 中國骨質疏松雜志, 2009, 15(3): 206-210.
14. 李強, 張柳, 李震, 等. 阿侖膦酸鈉對前交叉韌帶切斷大鼠關節軟骨退變的影響. 中國矯形外科雜志, 2010, 18(14): 1200-1204.
15. 程潭, 張柳, 李震, 等. 阿侖膦酸鈉對兔膝骨關節炎關節軟骨及軟骨下骨保護的作用. 中國老年學雜志, 2010, 30(24): 3695-3698.
16. Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
17. Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
18. Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
19. Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
20. 柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯合骨肽注射液治療膝骨性關節炎療效分析. 中國誤診學雜志, 2011, 11(31): 7646-7647.
21. 李亞芹. 針刀松解術聯合阿侖膦酸鈉治療膝關節退行性骨病. 臨床和實驗醫學雜志, 2011, 10(11): 853, 856.
22. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.

《中國修復重建外科雜志》

阿侖膦酸鈉對骨關節炎關節軟骨保護作用的研究進展

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《中國修復重建外科雜志》

阿侖膦酸鈉對骨關節炎關節軟骨保護作用的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料