肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義_《中國呼吸與危重監護雜志》

作者：

徐春華 , 于力克 , 張宇

南京市胸科醫院呼吸科( 江蘇南京 210029);

關鍵詞：

肺癌生長激素釋放肽瘦素

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目的探討肺癌患者血清生長激素釋放肽和瘦素水平的變化及意義。方法應用放射免疫分析法和酶聯免疫吸附法( ELISA) 測定46 例肺癌患者血清中生長激素釋放肽和瘦素水平的變化, 并與30 例正常健康人作比較。結果肺癌患者血清生長激素釋放肽和瘦素水平均高于正常人( P lt;0. 01) , 且兩者呈正相關性。結論檢測肺癌患者血清生長激素釋放肽和瘦素水平的變化對疾病的監測具有重要的臨床價值。

引用本文： 徐春華,于力克,張宇. 肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義. 中國呼吸與危重監護雜志, 2010, 9(5): 537-538. doi: 復制

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2.	Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
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5.	Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
6.	Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
7.	Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
8.	Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
9.	Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
10.	Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
11.	Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
12.	Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.

1. Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
2. Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
3. 任珂明, 厲有名. Ghrelin 及其受體在腫瘤發生中的作用. 國外醫學· 老年醫學分冊, 2006, 27 : 196-200.
4. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
6. Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
7. Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
8. Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
9. Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
10. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
11. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
12. Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.

《中國呼吸與危重監護雜志》

肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義

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《中國呼吸與危重監護雜志》

肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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