阻塞性睡眠呼吸暫停低通氣綜合征男女患者生物學特征分析_《中國呼吸與危重監護雜志》

作者：

王立曼 ¹ , 周光耀 ¹ , 劉亞峰 ¹ , 李春華 ¹ , 雷飛 ² , 唐向東 ² , 梁宗安 ³

1 四川大學華西醫院耳鼻咽喉-頭頸外科( 四川成都 610041) ;;
2 四川大學華西醫院睡眠醫學中心( 四川成都 610041) ;;
3 四川大學華西醫院呼吸內科( 四川成都 610041) 通訊作者: 周光耀, E-mail: zhguangyao@ hotmail. com;

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阻塞性睡眠呼吸暫停低通氣綜合征呼吸暫停低通氣性別差異

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目的探討阻塞性睡眠呼吸暫停低通氣綜合征( OSAHS) 男女患者生物學特征的差異。方法對2004 年9 月至2005 年2 月就診于華西醫院睡眠實驗室的192 例患者進行標準化問卷調查, 并測量頸圍、腰圍、臀圍、身高、體重, 進行整夜多導睡眠圖( PSG) 監測, 比較男女OSAHS 患者的臨床表現、人體測量學及PSG指標的差異。結果呼吸暫停低通氣指數( AHI) 大于5 次/h 者170 例,診斷為OSAHS。其中男153 例( 90% ) , 女17 例( 10% ) 。男性OSAHS 患者平均年齡小于女性患者[ ( 45. 7 ±11. 4) 歲比( 58. 0 ±6. 1) 歲, P = 0. 000] ; 頸圍( [ 37. 6 ±3. 2] cm比( 35. 6 ±3. 2) cm, P =0. 000] 、腰臀比( 0. 94 ±0. 04 比0. 9 ±0. 06, P = 0. 000) 、AHI[ ( 36. 4 ±25. 7) 次/h 比( 21. 4 ±17. 4)次/h, P =0. 004] 、氧減指數[ ( 34. 5 ±27. 4) 次/h 比( 22. 2 ±20. 8) 次/h, P =0. 035] 高于女性OSAHS患者; 吸煙比例( 52. 9% 比5. 9% , P = 0. 000) 、飲酒比例( 46. 4% 比5. 9% , P = 0. 001) 也顯著高于女性。女性OSAHS患者晨起頭痛( 70. 6% 比26. 1% , P =0. 005) 、口干( 76. 5% 比47. 7% , P =0. 025) 、性格暴躁( 52. 9% 比19. 0% , P =0. 004) 和發生高血壓( 52. 9% 比20. 9%, P =0. 007) 的比例高于男性患者。結論男女OSAHS 患者在患病率、發病年齡、臨床表現及生物學行為等方面均存在一定的差異,了解這些差異將有助于深入認識女性OSAHS。

引用本文： 王立曼,周光耀,劉亞峰,李春華,雷飛,唐向東,梁宗安. 阻塞性睡眠呼吸暫停低通氣綜合征男女患者生物學特征分析. 中國呼吸與危重監護雜志, 2010, 9(5): 501-503. doi: 復制

1.	Duran J, Esnaola S, Rubio R, et al. Obstructive sleep apneahypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. AmJ Respir Crit Care Med, 2001, 163 :685-689.
2.	Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 328: 1230-1235.
3.	Young T. Analytic epidemiology studies of sleep disordered breathing: what explains the gender difference in sleep disordered breathing? Sleep, 1993 , 16: S1-S2 .
4.	中華醫學會耳鼻咽喉科學分會. 阻塞性睡眠呼吸暫停低通氣綜合征診斷依據和療效評定標準暨懸雍垂腭咽成形術適應證( 杭州) . 中華耳鼻咽喉科雜志, 2002, 37: 403-404 .
5.	Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered breathing in women: effects of gender. Am J Respir Crit Care Med, 2001, 163 : 608-613.
6.	Whittle AT, Marshall I, Mortimore IL, et al. Neck soft tissue and fat distribution: comparison between normal man and women by magnetic rensonance imaging. Thorax, 1999, 54 : 323-328.
7.	Guilleminault C, Stoohs R, Kim YD, et al. Upper airway sleepdisordered breathing in women. Ann Intern Med, 1995,122: 493-501.
8.	Redline S, Kump K, Tishler PV, et al. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med, 1994, 149: 722-726.
9.	Popovic RM, White DP. Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med, 1995, 152: 725-731.
10.	Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol, 1998, 84 :1055-1062.
11.	Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep disordered breathing. Arch Intern Med, 1994, 154: 2219-2224.
12.	Rosen CL. Obstructive sleep apnea syndrome( OSAS) in children:diagnostic challenge. Sleep, 1996, 19: S274-S277 .
13.	李潔, 王翎. 老年睡眠呼吸暫停綜合征的特點. 國際呼吸雜志,2008, 28: 357-359 .

1. Duran J, Esnaola S, Rubio R, et al. Obstructive sleep apneahypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. AmJ Respir Crit Care Med, 2001, 163 :685-689.
2. Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 328: 1230-1235.
3. Young T. Analytic epidemiology studies of sleep disordered breathing: what explains the gender difference in sleep disordered breathing? Sleep, 1993 , 16: S1-S2 .
4. 中華醫學會耳鼻咽喉科學分會. 阻塞性睡眠呼吸暫停低通氣綜合征診斷依據和療效評定標準暨懸雍垂腭咽成形術適應證( 杭州) . 中華耳鼻咽喉科雜志, 2002, 37: 403-404 .
5. Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered breathing in women: effects of gender. Am J Respir Crit Care Med, 2001, 163 : 608-613.
6. Whittle AT, Marshall I, Mortimore IL, et al. Neck soft tissue and fat distribution: comparison between normal man and women by magnetic rensonance imaging. Thorax, 1999, 54 : 323-328.
7. Guilleminault C, Stoohs R, Kim YD, et al. Upper airway sleepdisordered breathing in women. Ann Intern Med, 1995,122: 493-501.
8. Redline S, Kump K, Tishler PV, et al. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med, 1994, 149: 722-726.
9. Popovic RM, White DP. Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med, 1995, 152: 725-731.
10. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol, 1998, 84 :1055-1062.
11. Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep disordered breathing. Arch Intern Med, 1994, 154: 2219-2224.
12. Rosen CL. Obstructive sleep apnea syndrome( OSAS) in children:diagnostic challenge. Sleep, 1996, 19: S274-S277 .
13. 李潔, 王翎. 老年睡眠呼吸暫停綜合征的特點. 國際呼吸雜志,2008, 28: 357-359 .

《中國呼吸與危重監護雜志》

阻塞性睡眠呼吸暫停低通氣綜合征男女患者生物學特征分析

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《中國呼吸與危重監護雜志》

阻塞性睡眠呼吸暫停低通氣綜合征男女患者生物學特征分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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摘要全文圖表視頻參考文獻施引文獻補充材料