OSAHS 與氣道高反應性的相關性分析_《中國呼吸與危重監護雜志》

作者：

石平 , 熊小敏 , 曾茄 , 趙世財 , 馬兵 , 楊萍

廣元市中心醫院呼吸內科( 四川廣元 628000)通訊作者: 石平, E-mail: gyshiping@ 163 . com;

關鍵詞：

阻塞性睡眠呼吸暫停低通氣綜合征氣道反應性

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目的探討阻塞性睡眠呼吸暫停低通氣綜合征( OSAHS) 與氣道高反應性( AHR) 的關系。方法納入197 例可疑OSAHS 患者進行整夜多導睡眠( PSG) 監測和基礎肺功能測定, 同時進行支氣管舒張試驗或激發試驗以測定氣流受限可逆性和氣道反應性( 用PD20 -FEV1 表示) 。分析呼吸暫停低通氣指數( AHI) 與AHR 的相關性。結果 OSAHS 患者117 例, 其中3 例舒張試驗陽性, 25 例激發試驗陽性; 非OSAHS 患者80 例, 其中7 例存在AHR。OSAHS 患者AHR 發病率顯著高于非OSAHS 患者( 23. 9% 比8. 8% , P lt;0. 01) 。OSAHS 合并AHR 患者的AHI 值高于OSAHS非AHR 患者[ ( 30. 3 ±5. 1) 次/h 比( 23. 7 ±2. 4) 次/h, P lt; 0. 01) 。25 例患者存在AHR 的OSAHS 患者中,PD20 -FEV1為( 0. 98 ±0. 24) mg, AHI 為( 31. 8 ±4. 2) 次/h, 兩者之間呈正相關關系( r = 0. 62, P lt;0. 05) 。結論 OSAHS患者發生AHR 的危險性增加。

引用本文： 石平,熊小敏,曾茄,趙世財,馬兵,楊萍. OSAHS 與氣道高反應性的相關性分析. 中國呼吸與危重監護雜志, 2010, 9(3): 253-255. doi: 復制

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11.	Devouassoux G, Lévy P, Rossini E, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol, 2007, 119: 597-603 .

1. Alkhalil M, Schulman E, Getsy J. Obstructive sleep apnea syndrome and asthma: what are the links? J Clin Sleep Med, 2009, 5 : 71-78.
2. 中華醫學會呼吸病學分會睡眠呼吸疾病學組. 阻塞性睡眠呼吸暫停低通氣綜合征診治指南( 草案) . 中華結核和呼吸雜志,2002, 25: 195-198 .
3. 朱蕾, 劉又寧, 于潤江, 主編. 臨床肺功能. 北京: 人民衛生出版社, 2004, 257-260.
4. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive sumary. Eur Respir J,2008, 31: 143-178 .
5. Denjean A, Roux C, Herve P, et al. Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects. Am Rev Respir Dis, 1988, 138 : 789-793.
6. Valipour A, Makker HK, Hardy R, et al. Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder.Chest, 2002, 121: 1748 -1753 .
7. Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med, 2000 , 108 Suppl 4 a: 120S-125S.
8. Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest, 2002 , 21: 158-163.
9. Carpagnano GE, Kharitonov SA, Resta O, et al. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest, 2002, 122: 1162-1167.
10. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol, 2004, 22 : 789 -815.
11. Devouassoux G, Lévy P, Rossini E, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol, 2007, 119: 597-603 .

《中國呼吸與危重監護雜志》

OSAHS 與氣道高反應性的相關性分析

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《中國呼吸與危重監護雜志》

OSAHS 與氣道高反應性的相關性分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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