胰島素樣生長因子結合蛋白-3在肺癌患者中的測定及其臨床意義_《中國呼吸與危重監護雜志》

作者：

 皮佳俐 , 徐平 , 宋衛東 , 劉媛媛

北京大學深圳醫院呼吸內科（廣東深圳 518034）;

關鍵詞：

肺癌胰島素樣生長因子結合蛋白-3 免疫放射法

視頻：

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目的檢測胰島素樣生長因子結合蛋白-3（IGFBP-3）在非小細胞肺癌患者血清與支氣管肺泡灌洗液中的表達，探討其在肺癌診斷及預后中的臨床意義。方法運用免疫放射法（IRMA）檢測80例非小細胞肺癌患者，14例健康人外周血血清與支氣管肺泡灌洗液（BALF）中IGFBP-3的水平。結果肺癌組血清與支氣管肺泡灌洗液中IGFBP-3的表達顯著低于健康組（P lt;0.05），在有淋巴結轉移、遠處轉移及TNMⅢ~TNMⅣ的肺癌患者血清中，IGFBP-3的下降比無轉移者及TNMⅠ~TNMⅡ期者顯著（P lt;0.05）。肺癌組血清中IGFBP-3濃度分別與BALF中IGFBP-3濃度呈正相關（r=0.415，r=0.355，P均 lt;0.01）。結論檢測患者血清與支氣管肺泡灌洗液IGFBP-3的表達水平對肺癌的診斷、判斷預后是有用的指標。

引用本文： 皮佳俐 ,徐平,宋衛東,劉媛媛. 胰島素樣生長因子結合蛋白-3在肺癌患者中的測定及其臨床意義. 中國呼吸與危重監護雜志, 2008, 08(1): 57-60. doi: 復制

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1. Grimberg A，Cohen P.Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis.J Cell Physiol，2000，183：1-9.
2. Li BD，Khosravi MJ，Berkel HJ，et al.Free insulin-like growth factor-I and breast cancer risk.Int J Cancer，2001，91：736-739.
3. Baxter RC.Signalling pathways involved in antiproliferative effects of IGFBP-3：a review.Mol Pathol，2001，54：145-148.
4. Rajah R，Valentinis B，Cohen P.Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism.J Biol Chem，1997，272：12181-12188.
5. Hochscheid R，Jaques G，Wegmann B.Transfection of human insulin-like growth factor-binding protein-3 gene inhibits cell growth and tumorigenicity：a cell culture model for lung cancer.J Endocrinol，2000，166：553-563.
6. Butt AJ，Firth SM，King MA，et al.Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.J Biol Chem，2000，275：39174-39181.
7. Devi GR，Sprenger CC，Plymate SR，et al.Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.Prostate，2002，51：141-152.
8. MacDonald RG，Schaffer BS，Kang IJ，et al.Growth inhibition and differentiation of the human colon carcinoma cell line，Caco-2，by constitutive expression of insulin-like growth factor binding protein-3.J Gastroenterol Hepatol，1999，14：72-78.
9. Buckbinder L，Talbott R，Velasco-Miguel S，et al.Induction of the growth inhibitor IGF-binding protein 3 by p53.Nature，1995，377：646-649.
10. Christoph F，Weikert S，Kempkensteffen C，et al.Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications.Clin Cancer Res，2006，12：5040-5046.

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胰島素樣生長因子結合蛋白-3在肺癌患者中的測定及其臨床意義

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《中國呼吸與危重監護雜志》

胰島素樣生長因子結合蛋白-3在肺癌患者中的測定及其臨床意義

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