支氣管哮喘防治全球創議(GINA)將哮喘的嚴重程度分為三度四級，其中三級和四級屬于中度和重度哮喘。在整個哮喘人群當中，中重度哮喘大約只占1／3，但在臨床上輕度哮喘患者很少就診，中重度哮喘大約占就診患者的2／3甚至更多。中重度哮喘患者由于癥狀明顯，頻繁就診，因為哮喘控制不良，經常出現急性發作，需要住院治療，雖然人數不是很多，但占用了大部分的醫療資源。無論是從提高哮喘防治的整體水平的角度，還是從減少哮喘疾病負擔的角度，都應當將中重度哮喘作為哮喘長期管理的主要的目標人群。
Citation：
LIU Chuntao. Therapy adjustment for moderate and severe asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(5): 329-331. doi:
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- 1. National institutes of health，National heart，Lung and Blood Institute.Global strategy for asthma management and prevention.Revised，2006，http：//www.ginasthma.com/ Guidelineitem.asp.
- 2. Bateman ED，Boushey HA，Bousquet J，et al.Can guideline-defined asthma control be achieved?The Gaining Optimal Asthma ControL study.Am J Respir Crit Care Med，2004，170：836-844.
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- 4. Bateman ED，Jacques L，Goldfrad C，et al.Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down.J Allergy Clin Immunol，2006，117：563-570.
- 5. Woolcock AJ，Jenkins CR.Assessment of bronchial responsiveness as a guide to prognosis and therapy in asthma.Med Clin North Am，1990，74：753-765.
- 6. Rabe KF，Atienza T，Magyar P，et al.Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations：a randomised controlled，double-blind study.Lancet，2006，368：744-753.
