輸血相關性急性肺損傷_《中國呼吸與危重監護雜志》

作者：

萬小健 , 江來 , 朱科明 , 鄧小明

第二軍醫大學附屬長海醫院麻醉科（上海 200433）;

關鍵詞：

輸血相關性急性肺損傷

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

輸血相關性急性肺損傷（TRALI）是發生于輸血期間或輸血后的罕見并發癥，以急性缺氧和非心源性肺水腫為特點，因死亡率高（5%~10%）而越來越受到臨床關注[1]，據2004年美國食品藥品管理局（FDA）的數據，TRALI為輸血相關性死亡的首要因素[2]。根據文獻資料，輸注血制品、含血漿制品、新鮮冰凍血漿（FFP）和血小板的TRALI發生率分別約為1/5 000[3]，1/2 000[4]，1/7 900[5]和1/432[6]。據報道，所有血制品（除白蛋白外）均可引起TRALI[7]，甚至有作者懷疑大劑量給予白細胞介素-2（IL-2）也可能導致TRALI[8]。目前，我國有關TRALI的報道較少，僅有個別死亡案例報道[9，10]，而相關的研究報道很少，這可能與我們尚未認識到TRALI的危險性，以及對其的診斷率較低有關。

引用本文： 萬小健,江來,朱科明,鄧小明. 輸血相關性急性肺損傷. 中國呼吸與危重監護雜志, 2007, 6(2): 141-144. doi: 復制

1.	Webert KE，Blajchman MA.Transfusion-related acute lung injury.Curr Opin Hematol，2005，12：480-487.
2.	Goodman M，Webert KE，Arnold DM，et al.Proceedings of a consensus conference：towards an understanding of TRALI.Transfus Med Rev，2005，19：2-31.
3.	Popovsky MA，Moore SB.Diagnostic and pathogenetic considerations in transfusion-related acute lung injury.Transfusion，1985，25：573-577.
4.	Silliman CC，Paterson AJ，Dickey WO，et al.The association of biologically active lipids with the development of transfusion-related acute lung injury：a retrospective study.Transfusion，1997，37：719-726.
5.	Wallis JP，Lubenko A，Wells AW，et al：Single hospital experience of TRALI.Transfusion，2003，43：1053-1059.
6.	Silliman CC，Boshkov LK，Mehdizadehkashi Z，et al：Transfusion-related acute lung injury：Epidemiology and a prospective analysis of etiologic factors.Blood，2003，101：454-462.
7.	Swanson K，Dwyre DM，Krochmal J，et al.Transfusion-related acute lung injury (TRALI)：current clinical and pathophysiologic considerations.Lung，2006，184：177-185.
8.	Medeiros BC，Kogel KE，Kane MA.Transfusion-related acute lung injury (TRALI) following platelet transfusion in a patient receiving high-dose interleukin-2 for treatment of metastatic renal cell carcinoma.Transfus Apher Sci，2003，29：25-27.
9.	佟長青.輸血相關性急性肺損傷2例報告.中國綜合臨床，2002，18：1145.
10.	黃金水，曾憲平，黃廣南，等.輸血相關性急性肺損傷1例報告.中國臨床醫藥研究雜志，2003，87：8489-8490.
11.	Moore SB.Transfusion-related acute lung injury (TRALI)：clinical presentation，treatment，and prognosis.Crit Care Med，2006，34：S114-S117.
12.	Toy P，Popovsky MA，Abraham E，et al.Transfusion-related acute lung injury：definition and review.Crit Care Med，2005，33：721-726.
13.	Swanson K，Dwyre DM，Krochmal J，et al.Transfusion-related acute lung injury (TRALI)：current clinical and pathophysiologic considerations.Blood，2006，184：177-185.
14.	Silliman CC，Ambruso DR，Boshkov LK.Transfusion-related lung injury.Blood，2005，105：2266-2273.
15.	Rao RS，Howard CA，Teague TK.Pulmonary endothelial permeability is increased by fluid from packed red cell units but not by fluid from clinically-available washed units.J Trauma，2005，60：851-858.
16.	Popovsky MA，Abel MD，Moore SB.Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies.Am Rev Respir Dis，1983，128：185-189.
17.	Silliman CC.Transfusion-related acute lung injury.Transfus Med Rev，1999，13：177-186.
18.	Seeger W，Schneider U，Kreusler B，et al.Reproduction of transfusion-related acute lung injury in an ex vivo lung model.Blood，1990，76：1438-1444.
19.	Bux J，Becker F，Seeger W，et al.Transfusion-related acute lung injury due to HLA-A2 -specific antibodies in recipient and NB1-specific antibodies in donor blood.Br J Haematol，1996，93：707-713.
20.	Leger R，Palm S，Wulf H，et al.Transfusion-related lung injury with leukopenic reaction caused by fresh frozen plasma containing anti-NB1.Anesthesiology，1999，91：1529-1532.
21.	Zupanska B，Uhrynowska M，Konopka L.Transfusion-related acute lung injury due to granulocyte-agglutinating antibody in a patient with paroxysmal nocturnal hemoglobinuria.Transfusion，1999，39：944-947.
22.	Lucas G，Rogers S，Evans R，et al.Transfusion-related acute lung injury associated with interdonor incompatibility for the neutrophil-specific antigen HNA-1a.Vox Sang，2000，79：112-115.
23.	Kopko PM，Paglieroni TG，Popovsky MA，et al.TRALI：correlation of antigen-antibody and monocyte activation in donor-recipient pairs.Transfusion，2003，43：177-184.
24.	Dykes A，Smallwood D，Kotsimbos T，et al.Transfusion-related acute lung injury (TRALI) in a patient with a single lung transplant.Br J Haematol，2000，109：674-676.
25.	Palfi M，Berg S，Ernerudh J，et al.A randomized controlled trial of tranfusion-related acute lung injury：is plasma from multiparous blood donors dangerous? Transfusion，2001，41：317-322.
26.	Boshkov LK，Mehdizadehkashi Z，Alcorn J，et al.Failure to implicate anti-granulocyte or anti-HLA class I or class II antibodies as the major pathogenetic mechanism in a series of transfusion associated acute lung injury cases (TRALI).Blood，2001，98：828a.
27.	Gajic O，moore SB.Transfusion-related acute lung injury.Mayo Clin Proc 2005，80：766-770.
28.	Silliman CC.The two-event model of transfusion-related acute lung injury.Crit Care Med，2006，34：S124-S131.
29.	Silliman CC，Voelkel NF，Allard JD，et al.Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.J Clin Invest，1998，101：1458-1467.
30.	Silliman CC，Dickey WO，Paterson AJ，et al.Analysis of the priming activity of lipids generated during routine storage of platelet concentrates.Transfusion，1996，36：133-139.
31.	Silliman CC，Paterson AJ，Dickey WO，et al.The association of biologically active lipids with the development of transfusion-related acute lung injury：a retrospective study.Transfusion，1997，37：719-726.
32.	Khan，SY，Kelher MR，Heal JM，et al.Soluble CD40 ligand accumulates in stored blood components，primes neutrophils through CD40，and is a potential cofactor in the development of transfusion-related acute lung injury.Blood，2006，108：2455-2462.
33.	Bueter M，Thalheimer A，Schuster F，et al.Transfusion-related acute lung injury (TRALI) -- an important，severe transfusion-related complication.Langenbacks Arch Surg，2006，391：489-494.
34.	Mair DC，Hirschler N，Eastlund T.Blood donor and component management strategies to prevent transfusion-related acute lung injury (TRALI).Crit Care Med，2006，34：S137-S143.

1. Webert KE，Blajchman MA.Transfusion-related acute lung injury.Curr Opin Hematol，2005，12：480-487.
2. Goodman M，Webert KE，Arnold DM，et al.Proceedings of a consensus conference：towards an understanding of TRALI.Transfus Med Rev，2005，19：2-31.
3. Popovsky MA，Moore SB.Diagnostic and pathogenetic considerations in transfusion-related acute lung injury.Transfusion，1985，25：573-577.
4. Silliman CC，Paterson AJ，Dickey WO，et al.The association of biologically active lipids with the development of transfusion-related acute lung injury：a retrospective study.Transfusion，1997，37：719-726.
5. Wallis JP，Lubenko A，Wells AW，et al：Single hospital experience of TRALI.Transfusion，2003，43：1053-1059.
6. Silliman CC，Boshkov LK，Mehdizadehkashi Z，et al：Transfusion-related acute lung injury：Epidemiology and a prospective analysis of etiologic factors.Blood，2003，101：454-462.
7. Swanson K，Dwyre DM，Krochmal J，et al.Transfusion-related acute lung injury (TRALI)：current clinical and pathophysiologic considerations.Lung，2006，184：177-185.
8. Medeiros BC，Kogel KE，Kane MA.Transfusion-related acute lung injury (TRALI) following platelet transfusion in a patient receiving high-dose interleukin-2 for treatment of metastatic renal cell carcinoma.Transfus Apher Sci，2003，29：25-27.
9. 佟長青.輸血相關性急性肺損傷2例報告.中國綜合臨床，2002，18：1145.
10. 黃金水，曾憲平，黃廣南，等.輸血相關性急性肺損傷1例報告.中國臨床醫藥研究雜志，2003，87：8489-8490.
11. Moore SB.Transfusion-related acute lung injury (TRALI)：clinical presentation，treatment，and prognosis.Crit Care Med，2006，34：S114-S117.
12. Toy P，Popovsky MA，Abraham E，et al.Transfusion-related acute lung injury：definition and review.Crit Care Med，2005，33：721-726.
13. Swanson K，Dwyre DM，Krochmal J，et al.Transfusion-related acute lung injury (TRALI)：current clinical and pathophysiologic considerations.Blood，2006，184：177-185.
14. Silliman CC，Ambruso DR，Boshkov LK.Transfusion-related lung injury.Blood，2005，105：2266-2273.
15. Rao RS，Howard CA，Teague TK.Pulmonary endothelial permeability is increased by fluid from packed red cell units but not by fluid from clinically-available washed units.J Trauma，2005，60：851-858.
16. Popovsky MA，Abel MD，Moore SB.Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies.Am Rev Respir Dis，1983，128：185-189.
17. Silliman CC.Transfusion-related acute lung injury.Transfus Med Rev，1999，13：177-186.
18. Seeger W，Schneider U，Kreusler B，et al.Reproduction of transfusion-related acute lung injury in an ex vivo lung model.Blood，1990，76：1438-1444.
19. Bux J，Becker F，Seeger W，et al.Transfusion-related acute lung injury due to HLA-A2 -specific antibodies in recipient and NB1-specific antibodies in donor blood.Br J Haematol，1996，93：707-713.
20. Leger R，Palm S，Wulf H，et al.Transfusion-related lung injury with leukopenic reaction caused by fresh frozen plasma containing anti-NB1.Anesthesiology，1999，91：1529-1532.
21. Zupanska B，Uhrynowska M，Konopka L.Transfusion-related acute lung injury due to granulocyte-agglutinating antibody in a patient with paroxysmal nocturnal hemoglobinuria.Transfusion，1999，39：944-947.
22. Lucas G，Rogers S，Evans R，et al.Transfusion-related acute lung injury associated with interdonor incompatibility for the neutrophil-specific antigen HNA-1a.Vox Sang，2000，79：112-115.
23. Kopko PM，Paglieroni TG，Popovsky MA，et al.TRALI：correlation of antigen-antibody and monocyte activation in donor-recipient pairs.Transfusion，2003，43：177-184.
24. Dykes A，Smallwood D，Kotsimbos T，et al.Transfusion-related acute lung injury (TRALI) in a patient with a single lung transplant.Br J Haematol，2000，109：674-676.
25. Palfi M，Berg S，Ernerudh J，et al.A randomized controlled trial of tranfusion-related acute lung injury：is plasma from multiparous blood donors dangerous? Transfusion，2001，41：317-322.
26. Boshkov LK，Mehdizadehkashi Z，Alcorn J，et al.Failure to implicate anti-granulocyte or anti-HLA class I or class II antibodies as the major pathogenetic mechanism in a series of transfusion associated acute lung injury cases (TRALI).Blood，2001，98：828a.
27. Gajic O，moore SB.Transfusion-related acute lung injury.Mayo Clin Proc 2005，80：766-770.
28. Silliman CC.The two-event model of transfusion-related acute lung injury.Crit Care Med，2006，34：S124-S131.
29. Silliman CC，Voelkel NF，Allard JD，et al.Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.J Clin Invest，1998，101：1458-1467.
30. Silliman CC，Dickey WO，Paterson AJ，et al.Analysis of the priming activity of lipids generated during routine storage of platelet concentrates.Transfusion，1996，36：133-139.
31. Silliman CC，Paterson AJ，Dickey WO，et al.The association of biologically active lipids with the development of transfusion-related acute lung injury：a retrospective study.Transfusion，1997，37：719-726.
32. Khan，SY，Kelher MR，Heal JM，et al.Soluble CD40 ligand accumulates in stored blood components，primes neutrophils through CD40，and is a potential cofactor in the development of transfusion-related acute lung injury.Blood，2006，108：2455-2462.
33. Bueter M，Thalheimer A，Schuster F，et al.Transfusion-related acute lung injury (TRALI) -- an important，severe transfusion-related complication.Langenbacks Arch Surg，2006，391：489-494.
34. Mair DC，Hirschler N，Eastlund T.Blood donor and component management strategies to prevent transfusion-related acute lung injury (TRALI).Crit Care Med，2006，34：S137-S143.

《中國呼吸與危重監護雜志》

輸血相關性急性肺損傷

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國呼吸與危重監護雜志》

輸血相關性急性肺損傷

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料