31 case of advanced primary liver cancer were treated by using IL-2 and LAK cells in which 15 cases were combined with surgery (group A) and 16 cases were combined with chemotherpy (Group B). 7～14 months follow-up showed: In group A there was no recurence and metastasis, and the cell-mediated immunity was obviously improved. In group B, the average life time was more than 5.84 months, the tumor average diameter dicreased in 10 cases ,and the cee-mediated immunity was also improved. The role of immunotherapy combined with surgery or chemotherapy was discussed.
Citation：
Li Shaosen,Huang Yuan,Lu Quanshu,et al.. A REPORT ON THE TREATMENT OF PATIENTS WITH ADVANCED PRIMARY LIVER CANCER USING INTERLEUKIN-2 AND LYPHOKINE ACTIVATED KILLER CELLS COMVINED WITH SURGERY OR CHMOTHERAPY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 80-83. doi:
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李志，權啟鎮，齊風等.IL-2/LAK細胞聯合應用治療原發性肝癌.山醫學醫藥，1993；33(7)：5.
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砟文化.IL-2和5-Fu聯合治療晚期肝癌24例.實用癌癥雜志，1993；8(3)：181.
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張松平，王能進.原發性肝癌根治術后復發因素分析.天津醫藥，1993；21(11)：666.
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朱敏生，許祥裕，丁樹標等.5-Fu，MMC對外周血LAK細胞殺傷活性的影響.江蘇醫藥，1990；(2)：70.
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- 1. 吳孟超.肝臟外科進展.中華醫學會第十屆全國外科學術會議論文匯編，武漢：1993：1.
- 2. 常旭(綜述).原發性肝癌的免疫狀態膠免疫治療.國外醫學腫瘤學分冊，1992；2：136.
- 3. Rosnberg SA, Lotze MT, Yang JC, et al. Experience with use of high dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg, 1989;210(4):474.
- 4. 鄭鵬遠，段芳齡，王軍等.LAK細胞對人肝細胞的殺傷作用及其電鏡觀察.中華消化雜志，1993；13(3)：157.
- 5. 韓福剛，許紅兵，梁厚勤.LAK細胞和IL-2治療晚期肝癌10例.中華腫瘤雜志，1991；13(2)：145.
- 6. 李志，權啟鎮，齊風等.IL-2/LAK細胞聯合應用治療原發性肝癌.山醫學醫藥，1993；33(7)：5.
- 7. 砟文化.IL-2和5-Fu聯合治療晚期肝癌24例.實用癌癥雜志，1993；8(3)：181.
- 8. 張松平，王能進.原發性肝癌根治術后復發因素分析.天津醫藥，1993；21(11)：666.
- 9. 朱敏生，許祥裕，丁樹標等.5-Fu，MMC對外周血LAK細胞殺傷活性的影響.江蘇醫藥，1990；(2)：70.
