大腸癌患者血清及癌組織中胃泌素水平測定的臨床意義_《中國普外基礎與臨床雜志》

作者：

李家琪 ¹ , 何雙梧 ² , 李益仁 ¹ , 張連陽 ²

1. 解放軍第六十醫院外一科(大理671003)2. 第三軍醫大學三院普外科;

關鍵詞：

大腸癌胃泌素

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

放免法測定43例行大腸癌根治術患者空腹血清、癌組織及癌旁粘膜中胃泌素水平。結果：大腸癌患者空腹血清胃泌素水平明顯高于正常血對照組(Ｐ＜0.05)；根治術后卻明顯降低(Ｐ＜0.05)，且與血對照組比無顯著性差異(Ｐ＞0.05)。高分化腺癌組血清胃泌素水平變化明顯；癌組織及癌旁粘膜中胃泌素水平均高于正常大腸粘膜(Ｐ＜0.05)。本結果提示：胃泌素對大腸癌的生長可能有調控作用，測定血清及癌組織中胃泌素水平有助于了解大腸癌的生物學特性及指導對大腸癌的激素治療。

引用本文： 李家琪,何雙梧,李益仁,張連陽. 大腸癌患者血清及癌組織中胃泌素水平測定的臨床意義. 中國普外基礎與臨床雜志, 1998, 5(1): 16-18. doi: 復制

1.	Singh P, Walker JP, Townsend CM, et al.Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC26) in BALB/C mice. Cancer Res, 1986; 46∶1612.
2.	Watson SA, Durrant LG, Croshic JD,et al. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer, 1989； 43∶692.
3.	Smith JP, Wood JG, Soloman TE. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Digestive Dis Science, 1989; 34(2)∶171.
4.	Wang K, Beardshall K, Waters CM,et al. Postprandial hypergastrinameic in patients with colorectal cancer. Gut, 1991; 32∶1352.
5.	蔡文琴，王伯云.實用免疫細胞化學室. 成都：四川科學技術出版社，1988∶214.
6.	Nemeth J,Taylor B, Pauwels S, et al.Indentification of progastrin derived peptide in colorectal carcinoma extracts. Gut, 1993; 34(1)∶90.
7.	Waston SA, Durrant LG, Wencyk PM, et al.Intracellular gastrin in human gastrointestinal tumor cells. National Cancer Institute, 1991; 83(12)∶866.
8.	Hoosein NM, Diener PA, Curry RC, et al. Evidence for autocrin growth stimulation of cultured colon tumor cells by a gastrin cholecystokininlike peptide. Experimental Cell Research, 1990; 186∶15.
9.	張群星，曾民德，施堯等. 胃癌組織及癌旁粘膜的胰高血糖素、胰島素和胃泌素含量的測定. 中華消化雜志， 1991； 11(3)∶144.
10.	Imdall A， Eggstein ST, Crance C,et al. Growth of colorectal carcinoma cell:regulation in vitro by gastrin, pentagastrin and the gastrinreceptor antagonist proglumid. J Cancer Res Clinocol, 1989; 115∶388.
11.	Beauchamp RD, Townsand CM, Singh P,et al.Proglumid,a gastrin receptor antagonist, inhibit growth of colon cancer and enhances survival in mice. Ann Surg, 1985; 302(3)∶303.

1. Singh P, Walker JP, Townsend CM, et al.Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC26) in BALB/C mice. Cancer Res, 1986; 46∶1612.
2. Watson SA, Durrant LG, Croshic JD,et al. The in vitro growth response of primary human colorectal and gastric cancer cells to gastrin. Int J Cancer, 1989； 43∶692.
3. Smith JP, Wood JG, Soloman TE. Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Digestive Dis Science, 1989; 34(2)∶171.
4. Wang K, Beardshall K, Waters CM,et al. Postprandial hypergastrinameic in patients with colorectal cancer. Gut, 1991; 32∶1352.
5. 蔡文琴，王伯云.實用免疫細胞化學室. 成都：四川科學技術出版社，1988∶214.
6. Nemeth J,Taylor B, Pauwels S, et al.Indentification of progastrin derived peptide in colorectal carcinoma extracts. Gut, 1993; 34(1)∶90.
7. Waston SA, Durrant LG, Wencyk PM, et al.Intracellular gastrin in human gastrointestinal tumor cells. National Cancer Institute, 1991; 83(12)∶866.
8. Hoosein NM, Diener PA, Curry RC, et al. Evidence for autocrin growth stimulation of cultured colon tumor cells by a gastrin cholecystokininlike peptide. Experimental Cell Research, 1990; 186∶15.
9. 張群星，曾民德，施堯等. 胃癌組織及癌旁粘膜的胰高血糖素、胰島素和胃泌素含量的測定. 中華消化雜志， 1991； 11(3)∶144.
10. Imdall A， Eggstein ST, Crance C,et al. Growth of colorectal carcinoma cell:regulation in vitro by gastrin, pentagastrin and the gastrinreceptor antagonist proglumid. J Cancer Res Clinocol, 1989; 115∶388.
11. Beauchamp RD, Townsand CM, Singh P,et al.Proglumid,a gastrin receptor antagonist, inhibit growth of colon cancer and enhances survival in mice. Ann Surg, 1985; 302(3)∶303.

《中國普外基礎與臨床雜志》

大腸癌患者血清及癌組織中胃泌素水平測定的臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

大腸癌患者血清及癌組織中胃泌素水平測定的臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料