胃、結腸癌患者術后生長激素應用的價值評估_《中國普外基礎與臨床雜志》

作者：

1. 昆明醫學院第二附屬醫院普外科(昆明650101)2. 云南大理洲醫院普外科;

關鍵詞：

重組人生長激素胃腸道腫瘤蛋白分解代謝免疫功能術后疲勞綜合征

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為探討重組人生長激素(rhGH)對胃結腸癌患者術后蛋白分解代謝的影響，以及使用rhGH后能否改善腫瘤患者的免疫功能，減輕術后疲勞綜合征(POF)，將38例行根治性切除并經病理學證實的腫瘤患者(胃癌21例，結腸癌17例)分為對照組(n＝18)和rhGH治療組(n＝20)，兩組患者術后均給予早期腹腔聯合灌注化療和經中心靜脈施行的全胃腸外營養(total parenteral nutrition,TPN)支持，rhGH組術后第1～6天9∶30 am皮下注射8 U rhGH。結果：對照組術后第5、10天的血清白蛋白、前白蛋白、轉鐵蛋白和IgG、IgA、IgM、CD＋３、CD＋4及CD＋8水平均較術前明顯下降(Ｐ＜0.01)； rhGH治療組CD＋３、CD＋4及CD＋8水平術后第10天較術前明顯升高(Ｐ＜0.01)，其余變化無統計學意義；精神狀態明顯好于對照組。術后第10天，對照組患者體重下降3～5 kg，rhGH組下降1～2 kg(Ｐ＜0.01)。實驗結果提示：腫瘤患者在術后早期腹腔聯合灌注化療和TPN營養支持的前提下應用重組人生長激素，能通過增加蛋白合成以克服術后應激反應的蛋白分解代謝作用，改善宿主的免疫功能，減輕POF，有助于增強化療對腫瘤細胞的殺傷作用，提高患者對化療的耐受性。

引用本文： 陳嘉勇,張捷,譚晶,甘平,孫敏,陳雄志. 胃、結腸癌患者術后生長激素應用的價值評估. 中國普外基礎與臨床雜志, 1999, 6(6): 365-367. doi: 復制

1.	Stress ST, Beddoe AH, Hill GT, et al. Aggressive nutritional support does not prevent protein loss depise fat gain septic intensive care patient. J Trauma, 1987; 27(3)∶262.
2.	Phillips LS. Nutrition, somatomedins and the brain. metabolism, 1986; 35(8)∶78.
3.	Wilmore DW, Moylan JA, Bristow BF, et al. Anabolic effects of human growth hormone and high caloric feeding following thermal injury. Surg Gynecol Obstet, 1974; 138(6)∶87.
4.	Lesniak NA, Roth J, Gorden P, et al. Human growth hormone radeoreceptor assay using cultured human lymphocytes. Nature (New Biol), 1973; 241(3)∶20.
5.	Rapaport R, Sills IN, Green L, et al. Detection of human growth hormone receptors on IM9 cell s and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormonebinding protein levels. J Clin Endocrinol Metab, 1995; 80(9)∶2612.
6.	Gelato MC. Growth hormoneinsulinlike growth factor I and immuune function. Trends Endocrinol Metab, 1993; 4(6)∶106.
7.	Bozzola M, Valtorta A, Moretta A, et al. In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr, 1990; 117(4)∶596.
8.	Lee PD, Pivarnik JM, Bukar JG, et al. A randomized, placebocontrolled trial of combined insulinlike growth factor I and low dose growth homone for wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab, 1996; 81(8)∶2968.
9.	VaraThorbeck TR, RuizRequena E, Guerrero JA. Effects of human growth hormone on the catabolic state after surgical trauma. Horm Res, 1964; 45(6)∶55.
10.	Christensen T, Kehlet H. Postoperative fatigue. World J Surg, 1993; 17(2)∶220.
11.	Schroeder D, Hill GL. Predicting postoperative fatigue, importance of preoperative factors. World J Surg, 1993; 17(2)∶226.
12.	Ogilvy Stuart AL, Shalet SM. Tumor occurrence and recurrence. Hmor Res, 1992; 38(Suppl 1)∶50.
13.	任建安，姜軍，顧軍等. 營養支持加用生長抑素、生長激素促進腸外瘺快速愈合. 腸內與腸外營養， 1998； 3(5)∶125.

1. Stress ST, Beddoe AH, Hill GT, et al. Aggressive nutritional support does not prevent protein loss depise fat gain septic intensive care patient. J Trauma, 1987; 27(3)∶262.
2. Phillips LS. Nutrition, somatomedins and the brain. metabolism, 1986; 35(8)∶78.
3. Wilmore DW, Moylan JA, Bristow BF, et al. Anabolic effects of human growth hormone and high caloric feeding following thermal injury. Surg Gynecol Obstet, 1974; 138(6)∶87.
4. Lesniak NA, Roth J, Gorden P, et al. Human growth hormone radeoreceptor assay using cultured human lymphocytes. Nature (New Biol), 1973; 241(3)∶20.
5. Rapaport R, Sills IN, Green L, et al. Detection of human growth hormone receptors on IM9 cell s and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormonebinding protein levels. J Clin Endocrinol Metab, 1995; 80(9)∶2612.
6. Gelato MC. Growth hormoneinsulinlike growth factor I and immuune function. Trends Endocrinol Metab, 1993; 4(6)∶106.
7. Bozzola M, Valtorta A, Moretta A, et al. In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr, 1990; 117(4)∶596.
8. Lee PD, Pivarnik JM, Bukar JG, et al. A randomized, placebocontrolled trial of combined insulinlike growth factor I and low dose growth homone for wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab, 1996; 81(8)∶2968.
9. VaraThorbeck TR, RuizRequena E, Guerrero JA. Effects of human growth hormone on the catabolic state after surgical trauma. Horm Res, 1964; 45(6)∶55.
10. Christensen T, Kehlet H. Postoperative fatigue. World J Surg, 1993; 17(2)∶220.
11. Schroeder D, Hill GL. Predicting postoperative fatigue, importance of preoperative factors. World J Surg, 1993; 17(2)∶226.
12. Ogilvy Stuart AL, Shalet SM. Tumor occurrence and recurrence. Hmor Res, 1992; 38(Suppl 1)∶50.
13. 任建安，姜軍，顧軍等. 營養支持加用生長抑素、生長激素促進腸外瘺快速愈合. 腸內與腸外營養， 1998； 3(5)∶125.

《中國普外基礎與臨床雜志》

胃、結腸癌患者術后生長激素應用的價值評估

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Content

《中國普外基礎與臨床雜志》

胃、結腸癌患者術后生長激素應用的價值評估

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料