乳腺疾病中微血管的觀察分析_《中國普外基礎與臨床雜志》

作者：

1. 華西醫科大學附屬第一醫院普外科(成都610041)2. 華西醫科大學附屬第一醫院病理科3. 華西醫科大學臨床流行病學教研室;

關鍵詞：

乳腺癌微血管密度新生血管

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為觀察乳腺良惡性疾病中微血管密度(microvessel density,MVD)的分布以及MVD與乳腺癌腫瘤大小(T)、組織學分級、雌激素受體水平(ER)及腋淋巴結轉移的關系，用Ⅷ因子抗體作病理切片的免疫組織化學染色，在顯微鏡下進行微血管計數。結果：乳腺癌的MVD均值為30.8±19.4個/200倍視野，明顯大于乳腺良性腫瘤的MVD均值(16.09±7.9個/200倍視野)，Ｐ＜0.01；乳腺癌中，MVD與腫瘤大小、組織學分級及腋淋巴轉移有關(Ｐ＜0.05)，而與雌激素受體水平無關。本實驗結果提示：乳腺癌的MVD大于良性乳腺疾病者，可作為判斷乳腺癌患者預后的指標之一。

引用本文： 李宏江,敬靜,朱精強,趙揚冰,張世羽,史宗道. 乳腺疾病中微血管的觀察分析. 中國普外基礎與臨床雜志, 1999, 6(5): 285-287. doi: 復制

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5.	Guinerbretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst, 1994; 86(8)∶635.
6.	Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science, 1977; 195(38)∶880.
7.	Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet, 1992; 340(8828)∶1120.
8.	Da Silva ID, De Lima GR, Gebrim LH, et al. Invasive ductal carcinoma, fibroadenoma and adjacent breast stroma angiogenesis: an immunohistochemical and morphometrical study. Bull Assoc Anat Nancy, 1996; 80(250)∶17.
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10.	Weidner N, Semple SP, Welch WR, et al. Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma. N Engl J Med, 1991; 324(1)∶1.
11.	Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg, 1966; 164(3)∶491.

1. 李宏江，朱精強. 乳癌中微血管活性檢測的意義. 國外醫學·外科學分冊， 1998； (6)∶344.
2. Algire GH, Chalkley HW, Legallais FY, et al. Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions in mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst, 1945; 25(6)∶73.
3. Folkman J. Introduction: angiogenesis and cancer. Semin Cancer Biol, 1992; 84(3)∶47.
4. Gimbrone MA Jr, Gullino PM. Neovascularization induced by introcular xenografts of normal, preneoplastic, and neoplastic mouse mammary tissues. J Natl Cancer Inst, 1976; 56(2)∶305.
5. Guinerbretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease. J Natl Cancer Inst, 1994; 86(8)∶635.
6. Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science, 1977; 195(38)∶880.
7. Horak ER, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer. Lancet, 1992; 340(8828)∶1120.
8. Da Silva ID, De Lima GR, Gebrim LH, et al. Invasive ductal carcinoma, fibroadenoma and adjacent breast stroma angiogenesis: an immunohistochemical and morphometrical study. Bull Assoc Anat Nancy, 1996; 80(250)∶17.
9. 賈蘭玲，李振，胡萍等. 血型抗原單克隆抗體對乳腺癌新生血管的檢測及意義. 中國醫科大學學報， 1995； 24(1)∶99.
10. Weidner N, Semple SP, Welch WR, et al. Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma. N Engl J Med, 1991; 324(1)∶1.
11. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg, 1966; 164(3)∶491.

《中國普外基礎與臨床雜志》

乳腺疾病中微血管的觀察分析

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《中國普外基礎與臨床雜志》

乳腺疾病中微血管的觀察分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料