In this study, the role of newcastle disease virus (NDV) combined thermic solidified tumor vaccine in inhibiting growth of tumor and immune control was investigated, and rate of inhibiting tumor and cellular immunity were measured. The results showed that rate of inhibiting tumor in experimental group Ⅰ and Ⅱ were 24.8% and 41.1% respectively; average weight of tumor was significantly lower in both experimental groups than in control group, and activity of natural killing (NK) cells in experimental groups was higher than that in control group (Ｐ＜0.01). This suggests that NDV combined thermic solidified tumor vaccine can inhibit growth of tumor and improve activity of NK cells, and their effects are better than that of NDV.
Citation：
Li Xiaojun,Bai Yanting,Tian Fuzhou,et al.. STUDY ON ANTITUMOR ROLE OF NEWCASTLE DISEASE VIRUS COMBINED THERMIC SOLIDIFIED TUMOR VACCINE IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 276-277. doi:
Copy
Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Flangan AD, Love R, Tesar W. Propagation of newcastle disease virus in ehrlic ascies cells in vitro and in vivo. Proc Soc Exp Biol Med, 1955; 90(4)∶82.
|
| 2. |
黃禎祥， 張禮碧， 賈風蘭等. 病毒治療小鼠腹水瘤作用的研究. 中華腫瘤雜志， 1985； 7(5)∶332.
|
| 3. |
Cassel WA, Garett RE. Newcastle disease virus as an antineoplastic. Cancer, 1965; 18(3)∶863.
|
| 4. |
劉曉波， 田伏洲， 李小軍等. 熱處理小鼠H22肝癌細胞的抗腫瘤作用. 中華物理醫學雜志， 1997； 19(2)∶78.
|
| 5. |
曲增強， 吳孟超， 陳漢等. 新城疫病毒瘤苗對荷瘤小鼠的主動免疫治療作用. 實用癌癥雜志， 1996； 11(2)∶73.
|
| 6. |
Reichard KW, Lorence RM, Cascino J, et al. Newcastle disease virus selectively kills human tomor cells. J Surg Res, 1992; 52(6)∶448.
|
- 1. Flangan AD, Love R, Tesar W. Propagation of newcastle disease virus in ehrlic ascies cells in vitro and in vivo. Proc Soc Exp Biol Med, 1955; 90(4)∶82.
- 2. 黃禎祥， 張禮碧， 賈風蘭等. 病毒治療小鼠腹水瘤作用的研究. 中華腫瘤雜志， 1985； 7(5)∶332.
- 3. Cassel WA, Garett RE. Newcastle disease virus as an antineoplastic. Cancer, 1965; 18(3)∶863.
- 4. 劉曉波， 田伏洲， 李小軍等. 熱處理小鼠H22肝癌細胞的抗腫瘤作用. 中華物理醫學雜志， 1997； 19(2)∶78.
- 5. 曲增強， 吳孟超， 陳漢等. 新城疫病毒瘤苗對荷瘤小鼠的主動免疫治療作用. 實用癌癥雜志， 1996； 11(2)∶73.
- 6. Reichard KW, Lorence RM, Cascino J, et al. Newcastle disease virus selectively kills human tomor cells. J Surg Res, 1992; 52(6)∶448.
