胃癌患者CEA、CA19-9、CA72-4及幽門螺旋桿菌抗體測定及其臨床意義_《中國普外基礎與臨床雜志》

作者：

牛偉新 , 盛衛忠 , 秦新裕

上海醫科大學附屬中山醫院普外科(上海200032);

關鍵詞：

胃癌癌胚抗原幽門螺旋桿菌

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對162例經手術和病理證實的胃癌患者血中的腫瘤標記物CEA、CA19-9、CA72-4及幽門螺旋桿菌(HP)抗體進行了測定，并以90例非腫瘤患者作為對照。結果：胃癌組患者CEA、CA19-9及CA72-4的敏感性分別為24.0%、35.5%和21.9%，特異性分別為93%、77%和100%；陽性預測值(擬然比)分別為85.7%(3.24)、78.6%(1.52)和100%(0)，陰性預測值(擬然比)分別為39.9%(0.28)、33.0%(0.84)和38.9%(0.78)。CA19-9及CA72-4的含量隨腫瘤直徑的增大而明顯增高(Ｐ＜0.05)；當腫瘤浸潤深度增加時，CA19-9含量也顯著增高(Ｐ＜0.05)。在淋巴結轉移率＞50%或有遠處轉移的患者，其CEA、CA72-4及CA19-9含量顯著增加；在腫瘤分化差的患者，這3種腫瘤標記物的含量均明顯高于對照組(Ｐ＜0.05)。胃癌患者HP抗體陽性率為54%，對照組為22%(χ2＝23.319，Ｐ＜0.001；比數比為3.75，95%可信限為2.11～5.41，Ｐ＜0.01)。結論： CEA、CA19-9及CA72-4在胃癌的診斷性試驗中特異性高而敏感性低；CEA、CA19-9及CA72-4的含量與腫瘤直徑、浸潤深度、淋巴結和遠處的轉移及腫瘤的分化程度密切相關；HP的感染與胃癌的發生有一定關系。

引用本文： 牛偉新,盛衛忠,秦新裕. 胃癌患者CEA、CA19-9、CA72-4及幽門螺旋桿菌抗體測定及其臨床意義. 中國普外基礎與臨床雜志, 1999, 6(3): 162-165. doi: 復制

1.	Talley NJ, Zinsmeister AR, Weaver A, et al. Gastric adenocarcinoma and Helicobacter pylori infection. National Cancer Institute, 1991; 83(23)∶1734.
2.	Forman D, Newell DG, Fullerton F, et al. Association between infection with Helicobacter pylori and risk of gastric cacner: evidence from a prospective investigation. BMJ, 1991; 302(1)∶1302.
3.	Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med, 1965; 122(3)∶467.
4.	Jalanko H, Kuusela P, Roberts P, et al. Comparison of a new tumour marker, CA199 TM, with AFP and CEA in patients with upper gasrointestinal diseases. J Clin Pathol, 1984; 37(2)∶218.
5.	Quentmeier A, Schlag P, Geisen HP, et al. Evaluation of CA125 as a tumor marker for gastric and colorectal cancer in comparison to CEA and CA199. Eur J Surg Oncol, 1987; 13(3)∶197.
6.	Joypaul B, Browning M, Newman E, et al. Comparison of serum CA724 and CA199 levels in gastric cancer patients and correlation with recurrence. Am J Surg, 1995; 169(6)∶595.
7.	Shimizu N, Wakatsuki T, Murakami A, et al. Carcinoembryonic antigen in gastric cancer patients. Oncol, 1987; 44(4)∶240.
8.	Ikeda Y, Oomori H, Koyanagi N, et al. Prognostic value of combination assays for CEA and CA199 in gastric cancer. Oncol, 1995 ; 52(6)∶483.
9.	Maeta M, Yoshioka H, Shimizu T, et al. Carbohydrate antigen CA199 in tissues and sera from patients with gastric cancer. Oncol, 1990; 47(3)∶229.
10.	Kornek G, Depisch D, Temsch EM, et al. Comparative analysis of cancerassociated antigen CA195, CA199 and CEA in diagnosis, followup and monitoring of response to chemotherapy in patients with gastrointestinal cancer. J Cancer Res Clin Oncol, 1991; 117(5)∶493.
11.	Gupta M, Arciaga R, Bocci L, et al. Measurement of a monoclonalantibodydefined antigen (CA199) in the sera of patients with maliganant and nonmaliganat diseases. Cancer, 1985; 56(2)∶277.
12.	Nomura A, Stemmermann G, Chyou P, et al. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. New Engl J Med, 1991; 325(16)∶1132.
13.	Parsonnet J Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. New Engl J Med, 1991; 325(16)∶1127.
14.	Blaser M, PerezPerez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res, 1995; 55(10)∶2111.
15.	The Eurogast Study Group. An international association between Helicobacter pylori infection and gastric cancer. Lancet, 1993; 341(8857)∶1359.
16.	Kikuchi S, Wada O, Nakajima T, et al. Serum antiHelicobacter pylori antibody and gastric carcinoma among young adults. Cancer, 1995; 75(12)∶2789.

1. Talley NJ, Zinsmeister AR, Weaver A, et al. Gastric adenocarcinoma and Helicobacter pylori infection. National Cancer Institute, 1991; 83(23)∶1734.
2. Forman D, Newell DG, Fullerton F, et al. Association between infection with Helicobacter pylori and risk of gastric cacner: evidence from a prospective investigation. BMJ, 1991; 302(1)∶1302.
3. Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med, 1965; 122(3)∶467.
4. Jalanko H, Kuusela P, Roberts P, et al. Comparison of a new tumour marker, CA199 TM, with AFP and CEA in patients with upper gasrointestinal diseases. J Clin Pathol, 1984; 37(2)∶218.
5. Quentmeier A, Schlag P, Geisen HP, et al. Evaluation of CA125 as a tumor marker for gastric and colorectal cancer in comparison to CEA and CA199. Eur J Surg Oncol, 1987; 13(3)∶197.
6. Joypaul B, Browning M, Newman E, et al. Comparison of serum CA724 and CA199 levels in gastric cancer patients and correlation with recurrence. Am J Surg, 1995; 169(6)∶595.
7. Shimizu N, Wakatsuki T, Murakami A, et al. Carcinoembryonic antigen in gastric cancer patients. Oncol, 1987; 44(4)∶240.
8. Ikeda Y, Oomori H, Koyanagi N, et al. Prognostic value of combination assays for CEA and CA199 in gastric cancer. Oncol, 1995 ; 52(6)∶483.
9. Maeta M, Yoshioka H, Shimizu T, et al. Carbohydrate antigen CA199 in tissues and sera from patients with gastric cancer. Oncol, 1990; 47(3)∶229.
10. Kornek G, Depisch D, Temsch EM, et al. Comparative analysis of cancerassociated antigen CA195, CA199 and CEA in diagnosis, followup and monitoring of response to chemotherapy in patients with gastrointestinal cancer. J Cancer Res Clin Oncol, 1991; 117(5)∶493.
11. Gupta M, Arciaga R, Bocci L, et al. Measurement of a monoclonalantibodydefined antigen (CA199) in the sera of patients with maliganant and nonmaliganat diseases. Cancer, 1985; 56(2)∶277.
12. Nomura A, Stemmermann G, Chyou P, et al. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. New Engl J Med, 1991; 325(16)∶1132.
13. Parsonnet J Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. New Engl J Med, 1991; 325(16)∶1127.
14. Blaser M, PerezPerez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res, 1995; 55(10)∶2111.
15. The Eurogast Study Group. An international association between Helicobacter pylori infection and gastric cancer. Lancet, 1993; 341(8857)∶1359.
16. Kikuchi S, Wada O, Nakajima T, et al. Serum antiHelicobacter pylori antibody and gastric carcinoma among young adults. Cancer, 1995; 75(12)∶2789.

《中國普外基礎與臨床雜志》

胃癌患者CEA、CA19-9、CA72-4及幽門螺旋桿菌抗體測定及其臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

胃癌患者CEA、CA19-9、CA72-4及幽門螺旋桿菌抗體測定及其臨床意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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