術后脂肪乳劑短期輸注與脂代謝變化關系的前瞻性臨床研究_《中國普外基礎與臨床雜志》

作者：

顧巖 ¹ , 吳肇漢 ¹ , 鄭云紅 ²

1. 上海醫科大學中山醫院外科(上海200032)2. 上海醫科大學藥學院有機合成教研室;

關鍵詞：

脂肪乳劑術后脂代謝

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前瞻性地研究術后短期應用不含脂肪乳劑的腸外營養(PN)與含10%及20%脂肪乳劑的PN對行中等以上普外科手術患者血脂代謝的影響。將56例患者隨機分成對照組(ｎ＝18)、10% Intralipid組(ｎ＝19)及20% Intralipid組(ｎ＝19)，于術后接受5天PN支持。結果：術后10%組血總膽固醇(Tcho)及低密度脂蛋白膽固醇(LDLch)明顯高于20%組及對照組，增加的膽固醇以游離膽固醇(Fcho)為主；異常脂蛋白(LPX)及磷脂也均高于20%組及對照組。本實驗結果提示：脂肪乳劑中磷脂/甘油三酯(PL/TG)比值過高所產生的過剩磷脂是導致術后短期PN血Tcho蓄積的主要原因，其中LPX的形成起了重要的作用。與10% Intralipid相比，20% Intralipid對機體脂代謝影響較小，更適合于臨床使用。

引用本文： 顧巖,吳肇漢,鄭云紅. 術后脂肪乳劑短期輸注與脂代謝變化關系的前瞻性臨床研究. 中國普外基礎與臨床雜志, 1999, 6(2): 92-95. doi: 復制

1.	Talafant E, Tovarek J. Rapid colorimetric methods for quantitative LPX determination without electrophresis. Clin Chim Acta, 1978; 88(2)∶215.
2.	Zohrab WJ, McHattie JD, Jeejeebhoy KN, et al. Fat emulsion for I.V. administration: intralipid. Rx Bull, 1973; 4(1)∶45.
3.	Roulet M, Wiesel PH, Pilet M, et al. Effect of intravenously infused egg phospholipids on lipid and lipoprotein metabolism in postoperative trauma. JPEN, 1993; 17(2)∶107.
4.	Meguid MM, Kurzer M, Hayashi RJ, et al. Shorttime effect of fat emulsion on serum lipids in postoperative patient. JPEN, 1989; 13(1)∶77.
5.	Zohrab WB, McHattie JD, Jeejeebhoy KN, et al. Total parenteral nutrition with lipid. Gastroenterology, 1973; 64(4)∶583.
6.	Judd RH, Freund H, Deckelbaum RJ. Human plasma lipoproteins and total parenteral nutrition with intravenous fat emulsion. JPEN, 1984; 8(54)∶552.
7.	Carpentier YA. Intravascular metabolism of fat emulsions. Clin Nutr, 1989; 8(2)∶115.
8.	Hajri T, Ferezon J, Lutton C, et al. Effects of intravenous infusions of commercial fat emulsion on rat plasma lipoproteins: phospholipids in excess are the main precursors of lipoproteinXlike particles. Biochim Biophys Acta, 1990; 1047(2)∶121.
9.	Williams KJ, Scanu AM. Uptake of endogenous cholesterol by a synthetic lipoprotein. Biochim Biophys Acta, 1986; 875(2)∶183.
10.	Weinberg RB, Singh KK. Shortterm parenteral nutrition with glucose and intralipid: effects on serum lipids and lipoproteins. Am J Clin Nutr, 1989; 49(5)∶794.
11.	Tashiro T, Mashima Y, Yamamori H, et al. Increased lipoprotein X causes hyperlipidemia during intravenous administration of 10% fat emulsion in man. JPEN, 1991; 15(5)∶546.
12.	Breckenridge WC. The catabolism of very low density lipoproteins. Can J Biochem Cell Biol, 1985; 63(6)∶890.

1. Talafant E, Tovarek J. Rapid colorimetric methods for quantitative LPX determination without electrophresis. Clin Chim Acta, 1978; 88(2)∶215.
2. Zohrab WJ, McHattie JD, Jeejeebhoy KN, et al. Fat emulsion for I.V. administration: intralipid. Rx Bull, 1973; 4(1)∶45.
3. Roulet M, Wiesel PH, Pilet M, et al. Effect of intravenously infused egg phospholipids on lipid and lipoprotein metabolism in postoperative trauma. JPEN, 1993; 17(2)∶107.
4. Meguid MM, Kurzer M, Hayashi RJ, et al. Shorttime effect of fat emulsion on serum lipids in postoperative patient. JPEN, 1989; 13(1)∶77.
5. Zohrab WB, McHattie JD, Jeejeebhoy KN, et al. Total parenteral nutrition with lipid. Gastroenterology, 1973; 64(4)∶583.
6. Judd RH, Freund H, Deckelbaum RJ. Human plasma lipoproteins and total parenteral nutrition with intravenous fat emulsion. JPEN, 1984; 8(54)∶552.
7. Carpentier YA. Intravascular metabolism of fat emulsions. Clin Nutr, 1989; 8(2)∶115.
8. Hajri T, Ferezon J, Lutton C, et al. Effects of intravenous infusions of commercial fat emulsion on rat plasma lipoproteins: phospholipids in excess are the main precursors of lipoproteinXlike particles. Biochim Biophys Acta, 1990; 1047(2)∶121.
9. Williams KJ, Scanu AM. Uptake of endogenous cholesterol by a synthetic lipoprotein. Biochim Biophys Acta, 1986; 875(2)∶183.
10. Weinberg RB, Singh KK. Shortterm parenteral nutrition with glucose and intralipid: effects on serum lipids and lipoproteins. Am J Clin Nutr, 1989; 49(5)∶794.
11. Tashiro T, Mashima Y, Yamamori H, et al. Increased lipoprotein X causes hyperlipidemia during intravenous administration of 10% fat emulsion in man. JPEN, 1991; 15(5)∶546.
12. Breckenridge WC. The catabolism of very low density lipoproteins. Can J Biochem Cell Biol, 1985; 63(6)∶890.

《中國普外基礎與臨床雜志》

術后脂肪乳劑短期輸注與脂代謝變化關系的前瞻性臨床研究

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《中國普外基礎與臨床雜志》

術后脂肪乳劑短期輸注與脂代謝變化關系的前瞻性臨床研究

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料