膽囊癌組織中p21、p53及bcl-2癌基因蛋白的表達及意義_《中國普外基礎與臨床雜志》

作者：

陳勁松 ¹ , 熊壽芝 ² , 楊竹林 ²

1. 海南省人民醫院肝膽外科(海口570311)2. 湖南醫科大學附二院肝膽外科;

關鍵詞：

膽囊癌膽囊息肉免疫組化癌基因蛋白

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為探討膽囊良惡性病變組織中p21、p53及bcl-2癌基因蛋白的表達及其與膽囊癌預后的關系，以及在膽囊良惡性病變的鑒別診斷中的作用，采用免疫組織化學ABC法，分別測定了40例膽囊癌及8例膽囊腺瘤型息肉組織中p21、p53及bcl2癌基因蛋白的表達情況。結果：膽囊癌組織中p21、p53及bcl-2癌基因蛋白表達陽性率分別為52.5%、52.5%和70.0%；在膽囊腺瘤型息肉中3者分別為0%、0%和100%；其中p53蛋白表達陽性率在低分化腺癌中明顯高于高分化腺癌(Ｐ＜0.01)，bcl-2蛋白表達陽性率在低分化腺癌中也明顯低于高分化腺癌(Ｐ＜0.01)。本實驗結果提示：p21及p53蛋白表達可能是膽囊癌預后不良的重要指標，檢測p21、p53及bcl-2蛋白表達情況在膽囊癌與膽囊息肉的鑒別診斷中有一定意義。

引用本文： 陳勁松,熊壽芝,楊竹林. 膽囊癌組織中p21、p53及bcl-2癌基因蛋白的表達及意義. 中國普外基礎與臨床雜志, 1999, 6(2): 83-85. doi: 復制

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1. Kamel D, Puakkd P, Nuorva K, et al. p53 and CerbB protein expression in adenocarcinomas and ipithelial dysplasias of the gallbladder. J Pathol, 1993; 107(1)∶67.
2. Jansson DS, Radosevich JA, Carney WE, et al. An immunohistochemical analysis of ras oncogene expression in epithelial neoplasms of colon. Cancer, 1990; 65(2)∶1329.
3. Pilotl S, Collinni P, Rillke F, et al. Bcl2 protein expression in carcinomas originating from the follicular epitheliun of the tyroid gland. J Pathol, 1994; 72(1)∶337.
4. Masakiko Y, Takahiro F, Baisuke A, et al.Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer and chronic cholecystitis. Hum Pathol, 1993; 24(4)∶37.
5. Wee A, The M, Raju GC, et al. Clinical importance of p53 protein in gallbladder carcinoma and its precursor lesions. J Clin Pathol, 1994; 47(2)∶453.
6. Dia K, Doglioni C, Lourinol, et al. P53 and cerb B2 protein expression in adenocarcinomas and epithelial dysplasia of the gallbladder. J Pathol, 1993; 170(4)∶67.
7. Rasbridge SA, Gillett CE, Symour AM, et al. The effect of che-motherapy on morpholohy, cellular proliferation aptosis and oncoprotein expression in primary breast carcinoma. Cancer, 1994; 70(1)∶335.
8. 江希明，鄭樹，丁仁瑞. 腫瘤生物學. 第1版. 杭州：浙江科學技術出版社， 1990∶92～135.

《中國普外基礎與臨床雜志》

膽囊癌組織中p21、p53及bcl-2癌基因蛋白的表達及意義

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《中國普外基礎與臨床雜志》

膽囊癌組織中p21、p53及bcl-2癌基因蛋白的表達及意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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