生長抑素對人結腸癌裸鼠移植瘤的作用及機理_《中國普外基礎與臨床雜志》

作者：

何雙梧 , 趙言明 , 沈康強

第三軍醫大學大坪醫院野戰外科研究所普外科(重慶400042);

關鍵詞：

結腸癌生長抑素胃泌素裸鼠移植瘤

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建立人結腸癌細胞株SW480裸鼠移植瘤模型，觀察8肽生長抑素(SMS 201-995，SMS)對移植瘤的作用及機理。結果∶SMS組及SMS+PG(5肽胃泌素)組移植瘤的體積、重量、瘤細胞內cAMP、DNA、蛋白質含量、S期和G2M期細胞數及增殖指數均顯著低于PG組及對照組，PG組顯著高于對照組；而G0/G1期細胞數則顯著高于PG組及對照組，PG組顯著低于對照組。本實驗結果提示：生長抑素具有直接抑制人結腸癌細胞株SW480移植瘤生長的作用，又可抑制胃泌素對移植瘤的促增殖作用。這種作用機理是通過抑制瘤細胞內cAMP、DNA和蛋白質的合成，從而抑制瘤細胞從G0/G1期進入到S期和G2M期。這為大腸癌患者應用生長抑素類似物進行內分泌治療提供了實驗依據。

引用本文： 何雙梧,趙言明,沈康強. 生長抑素對人結腸癌裸鼠移植瘤的作用及機理. 中國普外基礎與臨床雜志, 1999, 6(1): 1-3. doi: 復制

1.	Itzeu BD, Lolova I, Davidoff M.Immunocytochemical and electromicroscopical data on the differentiation of somatostatincantaining cells in human lage intestin. Anat Anz Jena, 1988; 166(2)∶77.
2.	Smith JP, Solomon TE. Effects of gastrin, proglumide and somatostatin on growth of human colon cancer. Gastroenterology, 1988; 95(6)∶1541.
3.	Radulovic S, Schally AV, Reile H, et al. Inhibitory effects of antagonists of bombesin/gastrin releasing peptide (GRP) and somatostatin analog (RC160) on HT29 human colon cancers in nude mice. Acta Oncol, 1994; 33(6)∶693.
4.	Dy DY, Whitehead RH, Morris DL. SMS 201995 inhibits in vitro and in vivo growth of human colon cancer. Cancer Res, 1992; 52(2)∶917.
5.	Singh P, Syle S, Townsend CM. A long acting somatostatin analog (SRIF) (201995) and proglumide (PGL) inhibit the trophic and gastrin receptor (GR) regulatory of effects of pentagastrin (PG) on mouse colon cancer (MC26) cells in vivo. Gastroenterology, 1986; 90(10)∶1636.
6.	黃廣建. 生長抑素在腫瘤診治中的應用. 國外醫學外科學分冊， 1996； 23(2)∶84.
7.	Cascinu S, Ferro EO, Catalano G. A randomized trial of octreotide vs best supportive care only in advanced gastrointestinal cancer patients refractory to chemotherapy. Br J Cancer, 1995; 71(2)∶97.

1. Itzeu BD, Lolova I, Davidoff M.Immunocytochemical and electromicroscopical data on the differentiation of somatostatincantaining cells in human lage intestin. Anat Anz Jena, 1988; 166(2)∶77.
2. Smith JP, Solomon TE. Effects of gastrin, proglumide and somatostatin on growth of human colon cancer. Gastroenterology, 1988; 95(6)∶1541.
3. Radulovic S, Schally AV, Reile H, et al. Inhibitory effects of antagonists of bombesin/gastrin releasing peptide (GRP) and somatostatin analog (RC160) on HT29 human colon cancers in nude mice. Acta Oncol, 1994; 33(6)∶693.
4. Dy DY, Whitehead RH, Morris DL. SMS 201995 inhibits in vitro and in vivo growth of human colon cancer. Cancer Res, 1992; 52(2)∶917.
5. Singh P, Syle S, Townsend CM. A long acting somatostatin analog (SRIF) (201995) and proglumide (PGL) inhibit the trophic and gastrin receptor (GR) regulatory of effects of pentagastrin (PG) on mouse colon cancer (MC26) cells in vivo. Gastroenterology, 1986; 90(10)∶1636.
6. 黃廣建. 生長抑素在腫瘤診治中的應用. 國外醫學外科學分冊， 1996； 23(2)∶84.
7. Cascinu S, Ferro EO, Catalano G. A randomized trial of octreotide vs best supportive care only in advanced gastrointestinal cancer patients refractory to chemotherapy. Br J Cancer, 1995; 71(2)∶97.

《中國普外基礎與臨床雜志》

生長抑素對人結腸癌裸鼠移植瘤的作用及機理

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《中國普外基礎與臨床雜志》

生長抑素對人結腸癌裸鼠移植瘤的作用及機理

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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