血管生成與p53、c-erb B-2癌基因蛋白在乳腺非典型增生及癌變過程中的相關性_《中國普外基礎與臨床雜志》

作者：

劉勝春 , 吳凱南 , 厲紅元 , 張震寰

重慶醫科大學附屬第一醫院普外科（重慶400016）;

關鍵詞：

血管生成 p53基因蛋白 c-erb B-2基因蛋白乳腺非典型增生乳腺癌

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目的探討p53及c-erb B-2癌基因蛋白在乳腺非典型增生及癌變組織中的表達及其在非典型增生及癌變過程中與血管生成的關系。方法對103例正常乳腺、乳腺非典型增生及乳腺癌組織的p53及c-erb B-2癌基因蛋白及第8因子相關抗原FⅧ-RA進行免疫組化染色。對微血管內皮細胞面積(MEA)進行CIAS定量測定，并分析p53及c-erb B-2與MEA的相關性。結果在輕度非典型增生組織中，p53癌基因蛋白陽性表達組MEA(4 194.89±498.599 8)高于陰性組(3 216.94±803.939 4,t=2.302 4,P＜0.05)。中重度非典型增生組織中，p53陽性組MEA(4 525.82±1 360.827 7)高于陰性組（3 564.61±687.064 6,t=2.179 4,P＜0.05）。c-erb B-2與MEA無相關性(P＞0.05)。結論在乳腺非典型增生及癌變過程中，p53癌基因蛋白表達與血管生成具有明顯相關性。

引用本文： 劉勝春,吳凱南,厲紅元,張震寰. 血管生成與p53、c-erb B-2癌基因蛋白在乳腺非典型增生及癌變過程中的相關性. 中國普外基礎與臨床雜志, 2001, 8(5): 304-306. doi: 復制

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4. Kang S, Maeda K, Onoda N, et al. Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis 〔Ｊ〕. Int J Cancer, 1997; 74(5)∶502.
5. Gasparini G, Weidner N, Maluta S, et al. Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamouscell carcinoma 〔Ｊ〕. Int J Cancer, 1993； 55(5)∶739.
6. Giatromanolaki A, Koukourakis M, Kakolyris S, et al. Vascular endothelial growth factor, wildtype p53, and angiogenesis in early operable nonsmall cell lung cancer 〔Ｊ〕 . Clinical Cancer Research, 1998; 4(12)∶3017.
7. Toi M, Kashitani T, Tominaga T. Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma 〔Ｊ〕. Int J Cancer, 1993; 55(3)∶371.
8. Charpin C, Devictor B, Bergeret D, et al. CD31 quantitative immunocytochemical assays in breast carcinomas, correlation with current prognostic factors 〔Ｊ〕. Am J Clin Pathol, 1995; 103(4)∶443.
9. Dameron K, Volpert O, Tainsky M, et al. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin1 〔Ｊ〕. Science, 1994; 265(9)∶1582.
10. Tai D, Fan R, Roy B. Controlling the vasculature: angiogenesis, antiangiogenesis and vascular targeting of gene therapy 〔Ｊ〕. Trends Pharmacol Sci, 1995; 16(2)∶57.
11. Mukhopadhyay D, Tsilkas L, Sukhatme P. Wildtype p53 and Vsrc exera opposing influences on human vascular endothelial growth factor gene expression 〔Ｊ〕. Cancer Research, 1995; 55 (24)∶6161.
12. Borg A, Tandon K, Sigurdsson H, et al. Her2/neu applification predicts poor survival in nodepositive breast cancer 〔Ｊ〕. Cancer Research, 1990; 50(14)∶4332.
13. Horak E, Leek R, Klenk N, et al. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastasis and survival in breast cancer 〔Ｊ〕. Lancet, 1992; 340(7)∶1120.

《中國普外基礎與臨床雜志》

血管生成與p53、c-erb B-2癌基因蛋白在乳腺非典型增生及癌變過程中的相關性

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《中國普外基礎與臨床雜志》

血管生成與p53、c-erb B-2癌基因蛋白在乳腺非典型增生及癌變過程中的相關性

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料