Objective To investigate the growth of tumors and the natural life length of the rats after the adriamycinethylcellulose microspheres(ADM-EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries.
Methods ADM-EC mc were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc.
Results As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats.
Conclusion Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.
Citation：
PENG Fangxing,YAN Lnan,LIN Qiyuan,et al.. HEPATIC ARTERIAL CHEMOEMBOLIZATION OF ADRIAMYCIN-ETHYLCELLULOSE MICROSPHERES IN THE TREATMENT OF LIVER CANCER IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 138-140. doi:
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| 1. |
Kato T, Young K. Arterial chemoembolization with mitomycin microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrap elvic organs 〔J〕. Cancer, 1981； 48(3)∶674.
|
| 2. |
Najib N, Suleiman MS. The Kinetics of drug release from ethy cellulose solid dipersions 〔J〕. Drug Dev Ind Pharm, 1985； 11(12)∶2169.
|
| 3. |
盛浩，魏樹禮.阿霉素毫微球制劑的研究進展 〔J〕.國外醫學合成藥、生化藥、制劑分冊，1996； 17(1)∶34.
|
| 4. |
王義，吳孟超，張曉華等.肝動脈注射順鉑乙基纖維素微囊后血液及重要器官全面的分布研究 〔J〕.中華外科雜志，1990； 28(11)∶686.
|
| 5. |
楊繼金，朱永法，左龍京等.大白鼠轉移性肝癌模型的制作 〔J〕.中華放射學雜志，1993； 27(2)∶122.
|
| 6. |
Kan ZX, Krassnodar I, Anders L, et al. In vivo microscopy of hepatic tumors in animal model: a dynamic investigation of blood supply to hepatic metastasis 〔J〕. Radiology, 1993； 187(3)∶621.
|
| 7. |
張志榮，王丹，廖方義等.肝動脈栓塞米托蒽醌乙基纖維素微球的研究 〔J〕.藥學學報，1996； 31(8)∶626.
|
- 1. Kato T, Young K. Arterial chemoembolization with mitomycin microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrap elvic organs 〔J〕. Cancer, 1981； 48(3)∶674.
- 2. Najib N, Suleiman MS. The Kinetics of drug release from ethy cellulose solid dipersions 〔J〕. Drug Dev Ind Pharm, 1985； 11(12)∶2169.
- 3. 盛浩，魏樹禮.阿霉素毫微球制劑的研究進展 〔J〕.國外醫學合成藥、生化藥、制劑分冊，1996； 17(1)∶34.
- 4. 王義，吳孟超，張曉華等.肝動脈注射順鉑乙基纖維素微囊后血液及重要器官全面的分布研究 〔J〕.中華外科雜志，1990； 28(11)∶686.
- 5. 楊繼金，朱永法，左龍京等.大白鼠轉移性肝癌模型的制作 〔J〕.中華放射學雜志，1993； 27(2)∶122.
- 6. Kan ZX, Krassnodar I, Anders L, et al. In vivo microscopy of hepatic tumors in animal model: a dynamic investigation of blood supply to hepatic metastasis 〔J〕. Radiology, 1993； 187(3)∶621.
- 7. 張志榮，王丹，廖方義等.肝動脈栓塞米托蒽醌乙基纖維素微球的研究 〔J〕.藥學學報，1996； 31(8)∶626.
