Ⅳ型膠原在乳腺癌中的表達及其意義_《中國普外基礎與臨床雜志》

作者：

王曉東 , 楊金巧

四川大學華西醫院普外科（成都610041）;;
△研究生，現在四川省人民醫院普外科（成都610072）;

關鍵詞：

乳腺癌 Ⅳ型膠原蛋白基底膜浸潤轉移

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目的探討Ⅳ型膠原蛋白在乳腺癌中的表達情況及其與臨床病理間的關系。方法應用Ⅳ型膠原蛋白單克隆抗體，采用鏈親和素（LSAB）法檢測93例乳腺惡性腫瘤及5例良性腫瘤組織中Ⅳ型膠原蛋白的表達。結果Ⅳ型膠原蛋白表達與乳腺癌患者腋窩淋巴結受累、生存時間及腫瘤大小有關。Ⅳ型膠原蛋白表達缺乏組5年生存率為29.69%，明顯低于表達完整組的5年生存率（81.43%），P＜0.05；隨著腫瘤的長大，Ⅳ型膠原表達完整率由53.8%降至10.3%，兩者間呈正相關（r=0.219）。結論檢測Ⅳ型膠原在乳腺癌基底膜中的表達狀況，將有助于乳腺癌預后的判斷及治療方案的制訂。

引用本文： 王曉東,楊金巧. Ⅳ型膠原在乳腺癌中的表達及其意義. 中國普外基礎與臨床雜志, 2002, 9(5): 303-305. doi: 復制

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1. Fridman R, Alon Y, Doljanski F, et al. Cell interaction with the extracellular matrices produced by endothelial and fibroblasts [J]. Exp Cell Res, 1985; 158(2)∶461.
2. Aznavoorian S, Murphy AM, StellerStevenson WG, et al. Molecular aspects of tumor cell invasion and metastasis [J]. Cancer, 1993; 71(4)∶1368.
3. Sobin LH, Wittekind C. TNM classification of malignant tumors [M]. 5th ed. New York: Gohn Wiley and Sons Inc, 1997∶123-167.
4. Campo E, Merino MJ, Tavassoli FA, et al. Evaluation of basement membrane components and the 72 kDa type Ⅳ Collagenase in serous tumors of the ovary [J]. Am J Surg Pathol, 1992; 16(5)∶500.
5. Birembaut P, Caron Y, Adnet JJ, et al. Usefulness of basement membrane markers in tumoural pathology [J]. J Pathol, 1985; 145(4)∶283.
6. Mahfouz SM, Chevallier M, Grimaud JA. Distribution of the major connective matrix components of the stromal reaction in breast carcinoma. An immunohistochemical study [J]. Cell Mol Biol, 1987; 33(4)∶453.
7. Albrechtsen R, Nielsen M, Wewer U, et al. Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin [J]. Cancer Res, 1981; 41(12 Pt 1)∶5076.
8. Barsky SH, Rao CN, Grotendorst GR, et al. Increased content of type Ⅴ collagen in desmoplasia of human breast carcinoma [J]. Am J Path, 1981; 108（3）∶279.
9. Clavel C, Doco M, Lallemand A, et al. Detection by in situ hybridization of messenger RNAs of collagen type I and Ⅳ in murine mammary [J]. Int J Cancer, 1989; 44(3)∶548.
10. Liotta LA. Tumor invasion and metastasis: role of the basement membrane. WarnerLambert ParkeDavis Award lecture [J]. Am J Pathol, 1984; 117(3)∶339.
11. Liotta LA, StetlarStevenson W. Metalloproteinase and malignant conversion: does correlation imply causality? [J]. J Natl Cancer Inst, 1989; 81(8)∶556.
12. 劉剛，韓德昌，嚴全梅. 口腔鱗癌Ⅳ型膠原和層粘連蛋白的表達與頸淋巴結轉移的關系 [J]. 臨床口腔醫學雜志，2000； 16（2）∶74.
13. 張健康，李曉麗，李亮成，等. Ⅳ型膠原、層粘連蛋白、纖維粘連蛋白在胃癌中表達的意義 [J]. 山西醫科大學學報，2000； 31（2）∶114.
14. 寶建中，鄭建明，周霖，等. 癌基因蛋白p21、p185、EGFR及LN、Ⅳ型膠原在骨肉瘤中的表達 [J]. 腫瘤防治研究，1999； 26（4）∶265.
15. Reed JA, Loganzo F Jr, Shea CR, et al. Loss of expression of the p16/cyclindependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression [J]. Cancer Res, 1995; 55(13)∶2713.

《中國普外基礎與臨床雜志》

Ⅳ型膠原在乳腺癌中的表達及其意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

Ⅳ型膠原在乳腺癌中的表達及其意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料