ObjectiveTo assess the effects of Radix Salviae Miltiorrhizae (RSM) on patency and proliferation lesion of autologous vein to artery grafts in the earlymiddle stage.MethodsAutologous jugular vein was grafted into abdominal artery in the rats. The rats were divided into two groups: RSM group and control group. The rats in RSM group were fed with RSM ［24 g/(kg·d )］,which began 1 day before operation and continued until harvesting. Vein grafts were harvested at 1,3 days, 1, 2, 4 and 8 weeks after surgery for examining the patency, thickness of intimamedia and expression of proliferating cell nuclear antigen (PCNA). ResultsNo significant differences existed in patency of vein grafts between the two groups (P gt;0.05). The intimamedia thickness of the vein grafts in RSM group decreased 1/3 compared with control group at 2, 4 and 8 weeks (P＜0.01). The PCNA positive cells in RSM group reduced significantly as compared to the control group (P＜0.01). ConclusionRSM can inhibit proliferation lesion of vein grafts but has no influence on patency of vein grafts in the earlymiddle stage.
Citation：
MA Xiaogan,SHI De.. Effect of Radix Salviae Miltiorrhizae on Patency and Proliferation Lesion of Autologous Vein to Artery Grafts in the EarlyMiddle Stage. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 232-234. doi:
Copy
Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Cox JL, Chiasson DA， Gotlieb AI. Stranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries [J]. Prog Cardiovasc Dis, 1991； 34（1）∶45.
|
| 2. |
鄒正午，徐理納，田金英. 迷迭香酸抗血栓和抗血小板聚集作用 [J]. 藥學學報，1993； 28（4）∶241.
|
| 3. |
周小明，陸再英，汪道文. 丹參防治實驗性動脈再狹窄及其機制的初步研究 [J].中國中西醫結合雜志，1996； 16（8）∶480.
|
| 4. |
王關嵩. 血小板源生長因子及其對血管平滑肌細胞作用的研究進展 [J].國外醫學臨床生物化學與檢驗學分冊，1997； 18(4)∶149.
|
| 5. |
Gryglewski RJ, Chlopicki S，Swies J, et al. Prostacyclin, nitric oxide， and atherosclerosis [J]. Ann N Y Acad Sci, 1995； 748∶ 194.
|
| 6. |
勞杰，顧玉東. 中藥對血管內皮細胞缺血缺氧損傷保護作用的實驗研究 [J]. 中華手外科雜志，1993； 9（1）∶39.
|
| 7. |
周小明，陸再英. 丹參注射液對培養的動脈平滑肌細胞增殖的影響 [J].中藥藥理與臨床，1995； 11（3）∶31.
|
| 8. |
顱坤平，趙升皓，王道生.鈣和鈣調素與血管平滑肌細胞增殖 [J].中國藥理學與毒理學雜志，1988； 2（3）∶166.
|
- 1. Cox JL, Chiasson DA， Gotlieb AI. Stranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries [J]. Prog Cardiovasc Dis, 1991； 34（1）∶45.
- 2. 鄒正午，徐理納，田金英. 迷迭香酸抗血栓和抗血小板聚集作用 [J]. 藥學學報，1993； 28（4）∶241.
- 3. 周小明，陸再英，汪道文. 丹參防治實驗性動脈再狹窄及其機制的初步研究 [J].中國中西醫結合雜志，1996； 16（8）∶480.
- 4. 王關嵩. 血小板源生長因子及其對血管平滑肌細胞作用的研究進展 [J].國外醫學臨床生物化學與檢驗學分冊，1997； 18(4)∶149.
- 5. Gryglewski RJ, Chlopicki S，Swies J, et al. Prostacyclin, nitric oxide， and atherosclerosis [J]. Ann N Y Acad Sci, 1995； 748∶ 194.
- 6. 勞杰，顧玉東. 中藥對血管內皮細胞缺血缺氧損傷保護作用的實驗研究 [J]. 中華手外科雜志，1993； 9（1）∶39.
- 7. 周小明，陸再英. 丹參注射液對培養的動脈平滑肌細胞增殖的影響 [J].中藥藥理與臨床，1995； 11（3）∶31.
- 8. 顱坤平，趙升皓，王道生.鈣和鈣調素與血管平滑肌細胞增殖 [J].中國藥理學與毒理學雜志，1988； 2（3）∶166.
