抗腫瘤新生血管形成治療實體腫瘤的研究進展_《中國普外基礎與臨床雜志》

作者：

四川大學華西醫院普外科（成都610041);

關鍵詞：

新生血管形成抗新生血管形成微血管密度腫瘤基因治療

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目的探討抗腫瘤新生血管形成治療實體腫瘤的可行性。方法對近5年的國內、外有關文獻進行綜述。結果實體腫瘤的生長、發展、轉移及預后好壞均與腫瘤新生血管形成密切相關。體外及動物實驗表明，抑制、阻斷腫瘤新生血管形成后可以抑制腫瘤的生長及轉移。結論抗腫瘤新生血管形成將成為治療實體腫瘤的一個有希望的新策略。

引用本文： 李宏江,綜述,趙揚冰,審校. 抗腫瘤新生血管形成治療實體腫瘤的研究進展. 中國普外基礎與臨床雜志, 2002, 9(3): 207-209. doi: 復制

1.	Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst, 1992; 84(24)∶1875.
2.	Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
3.	Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
4.	董為人，彭必友，李進，等. 細胞粘附與血管生成 [Ｊ].國外醫學外科學分冊，1998； 25（1）∶29.
5.	Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
6.	李宏江，敬靜，朱精強，等. 乳腺疾病中微血管的觀察分析 [Ｊ]. 中國普外基礎與臨床雜志，1999； 6（5）∶285.
7.	李宏江，趙揚冰，張世羽，等. 微血管檢測對乳腺癌患者預后的預示價值 [Ｊ]. 中華實驗外科雜志，1999； 16（增）∶49.
8.	Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
9.	Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
10.	Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
11.	章翔，吳景文，高大寬，等. 血管內皮生長因子165反義RNA治療人腦膠質瘤的實驗研究 [Ｊ].中華醫學雜志，2000； 80（5）∶386.
12.	Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
13.	Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
14.	Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
15.	宋述梅，壽成超. 原核表達的可溶性血管內皮生長因子受體對血管內皮生長因子活性的抑制 [Ｊ].中華醫學雜志， 2000； 80（3）∶226.
16.	Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
17.	Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
18.	Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
19.	Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
20.	Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
21.	郭文忠，楊治華，劉軍，等. 血管形成抑制因子HIAF1的克隆及其抗腫瘤作用 [Ｊ]. 中華腫瘤雜志， 2000； 22（1）∶19.
22.	Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
23.	夏景林，任正剛，楊秉輝，等. 血管形成抑制劑TNP470對肝癌組織VEGF表達的影響 [Ｊ]. 中華腫瘤雜志，2000； 22（1）∶26.

1. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst, 1992; 84(24)∶1875.
2. Folkman J. Diagnostic and therapeutic applications of angiogenesis research [Ｊ]. C R Acad Sci Paris Ⅲ, 1993; 316(9)∶914.
3. Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects [Ｊ]. J Mol Med, 1995; 73(7)∶333.
4. 董為人，彭必友，李進，等. 細胞粘附與血管生成 [Ｊ].國外醫學外科學分冊，1998； 25（1）∶29.
5. Guinebretiere JM, Le Monique G, Gavoille A, et al. Angiogenesis and risk of breast cancer in women with fibrocystic disease [Ｊ]. J Natl Cancer Inst, 1994; 86(8)∶635.
6. 李宏江，敬靜，朱精強，等. 乳腺疾病中微血管的觀察分析 [Ｊ]. 中國普外基礎與臨床雜志，1999； 6（5）∶285.
7. 李宏江，趙揚冰，張世羽，等. 微血管檢測對乳腺癌患者預后的預示價值 [Ｊ]. 中華實驗外科雜志，1999； 16（增）∶49.
8. Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastasis of biopsy material in rabbit thyroid and canine intestinal segment [Ｊ]. Ann Surg, 1966; 164(3)∶491.
9. Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin [Ｊ]. J Clin Invest, 1995; 96(4)∶1815.
10. Im SA, GomezManzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo [Ｊ]. Cancer Res, 1999; 59(4)∶895.
11. 章翔，吳景文，高大寬，等. 血管內皮生長因子165反義RNA治療人腦膠質瘤的實驗研究 [Ｊ].中華醫學雜志，2000； 80（5）∶386.
12. Borgstrom P, Bourdon MA, Hillan KJ, et al. Neutralizing antivascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo [Ｊ]. Prostate, 1998; 35(1)∶1.
13. Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8795.
14. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endotheliumspecific receptor tyrosine kinase Tie2[Ｊ]. Proc Natl Acad Sci USA, 1998; 95(15)∶8829.
15. 宋述梅，壽成超. 原核表達的可溶性血管內皮生長因子受體對血管內皮生長因子活性的抑制 [Ｊ].中華醫學雜志， 2000； 80（3）∶226.
16. Lin H, Lu H, Griscelli F, et al. Adenovirusmediated delivery of a uPA/uPAR antagonist suppresses angiogenesisdependent tumor growth and dissemination in mice [Ｊ]. Gene Ther, 1998; 5(8)∶1105.
17. Griscelli F, Li H, BennaceurGriscelli A, et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest [Ｊ]. Proc Natl Acad Sci USA, 1998; 95(11)∶6367.
18. Valente P, Fassina G, Melchiori A, et al. TIMP2 overexpression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis [Ｊ]. Int J Cancer, 1998; 75(2)∶246.
19. Zabrenetzky V, Harris CC, Steeg PS, et al. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines [Ｊ]. Int J Cancer, 1994; 59(2)∶191.
20. Zajchowcki DA, Band V, Trask DK, et al. Suppression of tumorforming ability and related traits in MCF7 human breast cancer cells by fusion with immortal mammary epithelial cells [Ｊ]. Proc Natl Acad Sci USA, 1990; 87(6)∶2314.
21. 郭文忠，楊治華，劉軍，等. 血管形成抑制因子HIAF1的克隆及其抗腫瘤作用 [Ｊ]. 中華腫瘤雜志， 2000； 22（1）∶19.
22. Singh Y, Shikata N, Kiyozuka Y, et al. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP470 on breast cancer cell lines in vitro and in vivo [Ｊ]. Breast Cancer Res Treat, 1997; 45(1)∶15.
23. 夏景林，任正剛，楊秉輝，等. 血管形成抑制劑TNP470對肝癌組織VEGF表達的影響 [Ｊ]. 中華腫瘤雜志，2000； 22（1）∶26.

《中國普外基礎與臨床雜志》

抗腫瘤新生血管形成治療實體腫瘤的研究進展

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《中國普外基礎與臨床雜志》

抗腫瘤新生血管形成治療實體腫瘤的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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