血管內皮生長因子及微血管密度與胃癌進展的關系_《中國普外基礎與臨床雜志》

作者：

王天寶 , 李兆亭

山東大學齊魯醫院普外科(濟南250012);

關鍵詞：

胃癌血管內皮生長因子微血管密度免疫組織化學

視頻：

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目的探討血管內皮生長因子(VEGF)及微血管密度(MVD)與胃癌臨床病理因素的關系。方法應用免疫組織化學(SP)方法測定胃癌及胃良性病變中VEGF表達及MVD。結果胃癌組VEGF表達陽性率為75.0%，胃良性病變組為5.0%(P＜0.05)；未浸潤漿膜層者為50.0%，浸潤漿膜層者為95.5%(P＜0.05)；有淋巴結轉移者為82.8%，無淋巴結轉移者為54.5%(P＜0.05)；伴有遠處轉移者為100%，不伴有遠處轉移者為71.0%(P＜0.05)； pTNM分期屬Ⅰ、Ⅱ期者為53.1%，Ⅲ、Ⅳ期者為89.6%(P＜0.05)。胃良性病變的MVD顯著低于胃癌組(P＜0.001); 浸潤深度達漿膜層、有淋巴結轉移和遠處轉移及pTNM屬Ⅲ、Ⅳ期者的MVD顯著升高，其差異有顯著性意義。VEGF表達與MVD明顯相關。結論VEGF上調及MVD增加對胃癌生長具有促進作用。

引用本文： 王天寶,李兆亭. 血管內皮生長因子及微血管密度與胃癌進展的關系. 中國普外基礎與臨床雜志, 2002, 9(3): 159-160. doi: 復制

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1. Ferrara N,Henzed WJ.Pictuitary follicular cells secrete a novel heparinbinding growth factor specific for vascular endothelial cells [J]. Biochem Biophys Res Common，1989； 161(2)∶851.
2. Senger DR, Connolly DT,Vande Water L,et al.Purification and NH2terminal amino acid sequence of guinea pig tumorsecreted vascular permeability factor [J]. Cancer Res,1990; 50(6)∶1774.
3. Balsari A, Jeanette AM, Maria I, et al. Correlation between tumor vascularity,vascular endothelial growth factor production by tumor cells,serum vascular endothelial growth factor levels,and serum angiogenic activity in patients with breast carcinoma [J]. Laboratory Investigation,1999; 79(7)∶897.
4. Pepper MS, Wasi W, Feriara N, et al. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells [J]. Exp Cell Res, 1994; 210(2)∶298.
5. 曹世龍主編. 腫瘤學新理論與新技術 \[M\].第1版. 上海: 上海科技教育出版社, 1997∶477～479.
6. Sternfeld T, Foss HD, Kruschewski M, et al. The prognostic significance of tumor vascularization in patients with localized colorectal cancer [J]. Int J Colorectal Dis，1999； 14(6)∶272.

《中國普外基礎與臨床雜志》

血管內皮生長因子及微血管密度與胃癌進展的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

血管內皮生長因子及微血管密度與胃癌進展的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料