促凋亡基因bad的表達與肝內膽管細胞癌分化的關系_《中國普外基礎與臨床雜志》

作者：

閆慶國 , 師建國 , 王文勇 , 李玉松 , 黃高昇 , 王文亮

第四軍醫大學西京醫院病理科（西安710032）;

關鍵詞：

內膽管細胞癌凋亡 bad基因免疫組織化學

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目的探討促凋亡基因bad在原發性肝內膽管細胞癌（ICC）中的表達及其與腫瘤分化程度的關系。方法采用免疫組織化學Dako Envision方法，對48例原發性肝內膽管細胞癌（ICC組）和25例肝細胞肝癌的癌旁肝組織匯管區膽管上皮組織（對照組）中bad基因的表達情況進行檢測。結果bad基因在ICC中的表達陽性率明顯高于對照組（P＜0.01）；在中、低分化的ICC中bad基因的陽性表達水平明顯高于高分化的ICC（P lt;0.05）。結論在低分化的膽管細胞癌中bad基因的表達明顯增強,bad基因的表達與腫瘤的分化程度相關。

引用本文： 閆慶國,師建國,王文勇,李玉松,黃高昇,王文亮. 促凋亡基因bad的表達與肝內膽管細胞癌分化的關系. 中國普外基礎與臨床雜志, 2003, 10(3): 253-255. doi: 復制

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1. Van Cruchten S, Van Den Broeck W. Morphological and biochemical aspects of apoptosis, oncosis and necrosis [J]. Anat Histol Embryol, 2002; 31(4)∶214.
2. 閆慶國，王文亮，黃高昇. 促細胞凋亡bax在膽管癌中的表達與意義 [J]. 第四軍醫大學學報，1997； 18（2）∶139.
3. 閆慶國，王文亮，黃高昇. 膽管癌中抗凋亡基因bcl2的表達及意義 [J]. 臨床肝膽病雜志，1997； 13（4）∶194.
4. Ottilie S, Diaz JL, Horne W, et al. Dimerization properties of human BAD. Identification of a BH3 domain and analysis of its binding to mutant bcl2 and bclxL proteins [J]. J Biol Chem,1997; 272(49)∶30866.
5. Kelekar A, Chang BS, Harlan JE, et al. Bad is a BH3 domaincontaining protein that forms an inactivating dimer with bclxL [J]. Mol Cell Biol, 1997; 17(12)∶7040.
6. Hong JR, Wu JL.Induction of apoptotic death in cells via bad gene expression by infectious pancreatic necrosis virus infection [J]. Cell Death Differ, 2002; 9(2)∶113.
7. Ichinose M, Liu XH, Hagihara N, et al.Extracellular bad fused to toxin transport domains induces apoptosis [J]. Cancer Res, 2002; 62(5)∶1433.
8. Kohler T, Schill C, Deininger MW, et al.High bad and bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML) [J]. Leukemia, 2002; 16(1)∶22.
9. Schimmer AD, Hedley DW, Pham NA, et al. BAD induces apoptosis in cells overexpressing Bcl2 or BclxL without loss of mitochondrial membrane potential [J]. Leuk Lymphoma,2001; 42(3)∶429.
10. Hattori T, Ookawa N, Fujita R, et al. Heterodimerization of bcl2 and bclx(L) with bax and bad in colorectal cancer [J]. Acta Oncol, 2000; 39(4)∶495.

《中國普外基礎與臨床雜志》

促凋亡基因bad的表達與肝內膽管細胞癌分化的關系

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《中國普外基礎與臨床雜志》

促凋亡基因bad的表達與肝內膽管細胞癌分化的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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