轉化生長因子β在移植排斥中的作用_《中國普外基礎與臨床雜志》

作者：

昆明醫學院第二附屬醫院肝膽胰一病區（昆明650101）;

關鍵詞：

轉化生長因子β 移植物排斥基因多態性

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的介紹轉化生長因子β(TGFβ)及其與移植排斥的關系。方法復習近年相關文獻并加以綜述。結果TGFβ的免疫抑制作用可對抗移植器官在移植術早期遭受的排斥損傷；同時TGFβ能促進成纖維細胞分化，增加膠原生成，抑制膠原酶活性而降低膠原的分解，促進基質沉淀，引起移植器官纖維化及動脈粥樣硬化,TGFβ的基因多態性與此密切相關。此外，缺血再灌注損傷、免疫抑制劑亦對TGFβ的合成產生影響。結論TGFβ是一種具有多向性和多種功能的細胞因子，與急、慢性排斥反應的發展有關。

引用本文： 姜楠,綜述,李立,審校. 轉化生長因子β在移植排斥中的作用. 中國普外基礎與臨床雜志, 2003, 10(2): 179-181. doi: 復制

1.	Wallick SC,Figari IS,Morris RE,et al.Immunoregulatory role of transforming growth factor beta(TGFbeta)in development of killer cells: comparison of active and latent TGFbeta 1[Ｊ]. J Exp Med， 1990； 172(6)∶1777.
2.	Waltenberger J,Wanders A,Fellstrom B,et al.Induction of transforming growth factorbeta during cardiac allgraft rejection[Ｊ]. J Immunol，1993； 151(2)∶1147.
3.	Qin L,Chavin KD,Ding Y,et al.Gene transfer for transplantation. Prolongation of allograft survival with transforming growth factorbeta 1 [Ｊ]. Ann Surg，1994; 220(4)∶508.
4.	Isaka Y,Fujiwara Y,Ueda N,et al.Glomerulosclerosis induced by in vivo transfection of transforming growth factorbeta or plateletderived growth factor gene into the rat kidney [Ｊ]. J Clin Invest， 1993; 92(6)∶2597.
5.	Yamamoto T,Noble NA,Miller DE,et al.Sustained expression of TGFbeta 1 underlies development of progressive kidney fibrosis[Ｊ]. Kidney Int，1994; 45(3)∶916.
6.	Sharma VK,Bologa RM, Xu GP,et al.Intragraft TGFbeta1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy[Ｊ]. Kidney Int，1996; 49(5)∶1297.
7.	Sankaran D, Asderakis A, Asharaf S, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation[Ｊ]. Kidney Int, 1999; 56(1)∶281.
8.	ElGamel A,Sim E,Hasleton P,et al.Transforming growth factor beta(TGFbeta) and obliterative bronchiolitis following pulmnary transplantation[Ｊ]. J Heart Lung transplant，1999; 18(9)∶828.
9.	Charpin JM,Valcke J,Kettaneh L,et al.Peaks of transforming growth factorbeta mRNA in alveoral cells of lung transplant recipients as an early marker of chronic rejection[Ｊ]. Transplantation,1998; 65(5)∶752.
10.	ElGamel A,Awad M,Sim E,et al.Transforming growth factorbeta1 and lung allograft fibrosis[Ｊ]. Eur J Cardiothorac Surg，1998; 13(4)∶424.
11.	Awad MR,ElGamel A,Hasleton P,et al. Genotypic variation in the transforming growth factorbeta1 gene: association with transforming growth factorbeta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation [Ｊ]. Transplantation,1998; 66(8)∶101.
12.	ElGamel A,Awad MR,Hasleton PS,et al.Transforming growth factorbeta (TGFbeta) genotype and lung allograft fibrosis[Ｊ]. J Heart Lung Transplant, 1999; 18(6)∶517.
13.	De GrootKruseman HA,Baan CC,Mol WM,et al.Up regulated transforming growth factorbeta 1 mRNA expression in endomyocardial biopsies during the development of graft vascular disease after clinical heart transplantation[Ｊ]. Transplant Proc,1999; 31(7)∶2724.
14.	Aziz T,Hasleton P,Hann AW,et al.Transforming growth factor beta in relation to cardiac allograft vasculopathy after heart transplantation[Ｊ]. J Thorac Cardiovasc Surg，2000; 119(4 pt 1)∶700.
15.	Densem CG,Hutchinson IV,Cooper A,et al.Polymorphism of the transforming growth factorbeta1 gene correlates with the development of coronary vasculopathy following cardiac transplantation[Ｊ]. J Heart Lung Transplant,2000; 19(6)∶551.
16.	Demirci G,Nashan B,Pichlmayr R.Fibrosis in chronic rejection of human liver allografts:expression patterns of transforming growth factor TGFbeta1 and TGFbeta3[Ｊ]. Transplantation,1996; 62(12)∶1776.
17.	Hadley GA,Rostapshova EA,Gomolka DM,et al.Regulation of the epithelial cellspecific integin,CD103,by human CD8+ cytolytic T lymphocytes[Ｊ]. Transplantation,1999; 67(11)∶1418.
18.	Robertson H, Wong WK,Talbot D,et al.Tubulitis after renal transplantation:demonstration of an association between CD103+ T cells,transforming growth factor beta1 expression and rejection grade[Ｊ]. Transplantation,2001; 71(2)∶306.
19.	Basile DP,Rovak JM,Martin DR,et al.Increased transforming growth factorbeta1 expression in regenerating rat renal tubules following ischemia injury[Ｊ]. Am J Physiol,1996; 270（3 Pt 2）∶F500.
20.	Mohamed MA,Robertson H,Booth TA,et al.TGFbeta expression in renal transplant biopsies:a comparative study between cyclosporinA and tacrolimus[Ｊ]. Transplantation,2000; 69（5）∶1002.
21.	Hutchinson IV.The role of transforming growth factorbeta in transplant rejection[Ｊ]. Transplant Proc,1999; 31(7A)∶9S.
22.	Khanna A,Cairns V,Hosenpud JD.Tacrolimus induces increased expression of transforming growth factorbeta1 in mammalian lymphoid as well as nonlymploid cells[Ｊ]. Transplantation,1999; 67（4）∶614.
23.	Hughes JR,Hughes VF,Trull AK,et al.Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus of microemulsified cyclosporine[Ｊ]. Transplantation,1999; 68（4）∶583.

1. Wallick SC,Figari IS,Morris RE,et al.Immunoregulatory role of transforming growth factor beta(TGFbeta)in development of killer cells: comparison of active and latent TGFbeta 1[Ｊ]. J Exp Med， 1990； 172(6)∶1777.
2. Waltenberger J,Wanders A,Fellstrom B,et al.Induction of transforming growth factorbeta during cardiac allgraft rejection[Ｊ]. J Immunol，1993； 151(2)∶1147.
3. Qin L,Chavin KD,Ding Y,et al.Gene transfer for transplantation. Prolongation of allograft survival with transforming growth factorbeta 1 [Ｊ]. Ann Surg，1994; 220(4)∶508.
4. Isaka Y,Fujiwara Y,Ueda N,et al.Glomerulosclerosis induced by in vivo transfection of transforming growth factorbeta or plateletderived growth factor gene into the rat kidney [Ｊ]. J Clin Invest， 1993; 92(6)∶2597.
5. Yamamoto T,Noble NA,Miller DE,et al.Sustained expression of TGFbeta 1 underlies development of progressive kidney fibrosis[Ｊ]. Kidney Int，1994; 45(3)∶916.
6. Sharma VK,Bologa RM, Xu GP,et al.Intragraft TGFbeta1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy[Ｊ]. Kidney Int，1996; 49(5)∶1297.
7. Sankaran D, Asderakis A, Asharaf S, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation[Ｊ]. Kidney Int, 1999; 56(1)∶281.
8. ElGamel A,Sim E,Hasleton P,et al.Transforming growth factor beta(TGFbeta) and obliterative bronchiolitis following pulmnary transplantation[Ｊ]. J Heart Lung transplant，1999; 18(9)∶828.
9. Charpin JM,Valcke J,Kettaneh L,et al.Peaks of transforming growth factorbeta mRNA in alveoral cells of lung transplant recipients as an early marker of chronic rejection[Ｊ]. Transplantation,1998; 65(5)∶752.
10. ElGamel A,Awad M,Sim E,et al.Transforming growth factorbeta1 and lung allograft fibrosis[Ｊ]. Eur J Cardiothorac Surg，1998; 13(4)∶424.
11. Awad MR,ElGamel A,Hasleton P,et al. Genotypic variation in the transforming growth factorbeta1 gene: association with transforming growth factorbeta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation [Ｊ]. Transplantation,1998; 66(8)∶101.
12. ElGamel A,Awad MR,Hasleton PS,et al.Transforming growth factorbeta (TGFbeta) genotype and lung allograft fibrosis[Ｊ]. J Heart Lung Transplant, 1999; 18(6)∶517.
13. De GrootKruseman HA,Baan CC,Mol WM,et al.Up regulated transforming growth factorbeta 1 mRNA expression in endomyocardial biopsies during the development of graft vascular disease after clinical heart transplantation[Ｊ]. Transplant Proc,1999; 31(7)∶2724.
14. Aziz T,Hasleton P,Hann AW,et al.Transforming growth factor beta in relation to cardiac allograft vasculopathy after heart transplantation[Ｊ]. J Thorac Cardiovasc Surg，2000; 119(4 pt 1)∶700.
15. Densem CG,Hutchinson IV,Cooper A,et al.Polymorphism of the transforming growth factorbeta1 gene correlates with the development of coronary vasculopathy following cardiac transplantation[Ｊ]. J Heart Lung Transplant,2000; 19(6)∶551.
16. Demirci G,Nashan B,Pichlmayr R.Fibrosis in chronic rejection of human liver allografts:expression patterns of transforming growth factor TGFbeta1 and TGFbeta3[Ｊ]. Transplantation,1996; 62(12)∶1776.
17. Hadley GA,Rostapshova EA,Gomolka DM,et al.Regulation of the epithelial cellspecific integin,CD103,by human CD8+ cytolytic T lymphocytes[Ｊ]. Transplantation,1999; 67(11)∶1418.
18. Robertson H, Wong WK,Talbot D,et al.Tubulitis after renal transplantation:demonstration of an association between CD103+ T cells,transforming growth factor beta1 expression and rejection grade[Ｊ]. Transplantation,2001; 71(2)∶306.
19. Basile DP,Rovak JM,Martin DR,et al.Increased transforming growth factorbeta1 expression in regenerating rat renal tubules following ischemia injury[Ｊ]. Am J Physiol,1996; 270（3 Pt 2）∶F500.
20. Mohamed MA,Robertson H,Booth TA,et al.TGFbeta expression in renal transplant biopsies:a comparative study between cyclosporinA and tacrolimus[Ｊ]. Transplantation,2000; 69（5）∶1002.
21. Hutchinson IV.The role of transforming growth factorbeta in transplant rejection[Ｊ]. Transplant Proc,1999; 31(7A)∶9S.
22. Khanna A,Cairns V,Hosenpud JD.Tacrolimus induces increased expression of transforming growth factorbeta1 in mammalian lymphoid as well as nonlymploid cells[Ｊ]. Transplantation,1999; 67（4）∶614.
23. Hughes JR,Hughes VF,Trull AK,et al.Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus of microemulsified cyclosporine[Ｊ]. Transplantation,1999; 68（4）∶583.

《中國普外基礎與臨床雜志》

轉化生長因子β在移植排斥中的作用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

轉化生長因子β在移植排斥中的作用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料