慢性胰腺炎動物模型研究進展_《中國普外基礎與臨床雜志》

作者：

陳啟龍 ¹ , 溫浩 ² , 李國威 ¹

1.西安交通大學第二醫院普外科（西安710004）;;
2.新疆醫科大學第一附屬醫院普外科（烏魯木齊830000）;

關鍵詞：

慢性胰腺炎實驗模型

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導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的探討慢性胰腺炎動物模型的制作方法及各類模型的特點。方法通過對近年來慢性胰腺炎動物模型的相關文獻的回顧，總結各模型的制作方法、特點及適合研究各種慢性胰腺炎的最佳模型。結果飲食、胰管結扎、蛙皮素、二丁基二氯化物（DBTC）、動脈注射微球、動脈結扎及胰管注射等方法可誘導不同的慢性胰腺炎動物模型。飲食法誘發自發性慢性胰腺炎，胰管結扎法和胰管注射法誘導慢性阻塞性胰腺炎，蛙皮素誘導復發性慢性胰腺炎，動脈注射微球和動脈結扎誘導慢性活動性胰腺炎。結論不同的方法均可誘導慢性胰腺炎模型，但各具特點。

引用本文： 陳啟龍,溫浩,李國威. 慢性胰腺炎動物模型研究進展. 中國普外基礎與臨床雜志, 2003, 10(6): 560-563. doi: 復制

1.	Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments [J]. Gastroenterology, 2001; 120(3)∶682.
2.	佟衛剛，盧實春，胡驥，等. 慢性胰腺炎的外科治療及遠期療效 [J]. 中國普外基礎與臨床雜志, 1999; 6(6)∶347.
3.	Ohashi K, Kim JH, Hara H, et al. WBN/Kob rats. A new spontaneously occurring model of chronic pancreatitis [J]. Int J pancreatol, 1990; 6(4)∶231.
4.	Su SB, Motoo Y, Xie MJ, et al. Expression of transforming growth factorbeta in spontaneous chronic pancreatitis in the WBN/Kob rat [J]. Dig Dis Sci, 2000; 45(1)∶151.
5.	耿智敏，向國安，韓慶，等. 轉化生長因子β1在膽管愈合過程中的表達及意義 [J]. 中國普外基礎與臨床雜志, 2000; 7(6)∶362.
6.	Su SB, Motoo Y, Iovanna JL, et al. Effect of camostat mesilate on the expression of pancreatitisassociated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis [J]. Pancreas, 2001; 23(2)∶134.
7.	Su SB, Motoo Y, Xie MJ, et al. Apoptosis in rat spontaneous chronic pancreatis: role of the Fas and Fas ligand system [J]. Dig Dis Sci, 2001; 46(1)∶166.
8.	Widdison AL, Alvarez C, Schwarz M, et al. The influence of ethanol on pancreatic blood flow in cats with chronic pancreatitis [J]. Surgery, 1992; 112(2)∶202.
9.	Karanjia ND, Widdison AL, Leung F, et al. Compartment syndrome in experimental chronic obstructive pancreatitis: effect of decompressing the main pancreatic duct [J]. Br J Surg, 1994; 81(2)∶ 259.
10.	Reber PU, Patel AG, Toyama MT, et al. Feline model of chronic obstructive pancreatitis: effects of acute pancreatic duct decompression on blood flow and interstitial pH [J]. Scand J Gastroenterol, 1999; 34(4)∶439.
11.	Toyama MT, Patel AG, Nguyen T, et al. Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis [J]. Ann Surg, 1997; 225(2)∶223.
12.	Patel AG, Reber PU, Toyama MT, et al. Effect of pancreaticojejunostomy on fibrosis, pancreatic blood flow, and interstitial pH in chronic pancreatitis: a feline model [J]. Ann Surg, 1999; 230(5)∶672.
13.	Reber PU, Patel AG, Lewis MP, et al. Stenting does not decompress the pancreatic duct as effective as surgery in experimental chronic pancreatitis [J]. Surgery, 1998; 124(3)∶561.
14.	李春艷，崔美芝，成曉松，等. 急性胰腺炎動物模型概況 [J]. 哈爾濱醫科大學學報, 1998; 32(4)∶308.
15.	姜永鋒，張延齡. 急性胰腺炎的實驗研究進展 [J]. 國外醫學外科學分冊, 1996; 23(1)∶13.
16.	NeuschwanderTetri BA, Burton FR, Presti ME, et al. Repetitive selflimited acute pancreatitis induces pancreatic fibrogenesis in the mouse [J]. Dig Dis Sci, 2000; 45(4)∶665.
17.	Murayama KM, Barent BL, Gruber M, et al. Characterization of a novel model of pancreatic fibrosis and acinar atrophy [J]. J Gastrointest Surg, 1999; 3(4)∶418.
18.	Miyahara T, Kawabuchi M, Goto M, et al. Morphological study of pancreatic endocrine in an experimental chronic pancreatitis with diabetes induced by stress and cerulein [J]. Ultrastruct Pathol, 1999; 23(3)∶171.
19.	Merkord J, Weber H, Sparmann G, et al. The course of pancreatic fibrosis induced by dibutyltin dichloride (DBTC) [J]. Ann N Y Acad Sci, 1999; 880∶231.
20.	Merkord J, Weber H, Jonas L, et al. The influence of ethanol on longterm effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats [J]. Hum Exp Toxicol, 1998; 17(3)∶144.
21.	Sparmann G, Merkord J, Jaschke A, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride [J]. Gasteroenterology, 1997; 112(5)∶1664.
22.	Sparmann G, Behrend S, Merkord J, et al. Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride [J]. Dig Dis Sci, 2001; 46(8)∶1647.
23.	Freiburghaus AU, Redha F, Ammann RW. Does actue pancreatitis progress to chronic pancreatitis? A microvascular pancreatitis model in the rat [J]. Pancreas, 1995; 11(4)∶374.
24.	Tanaka T, Ichiba Y, Miura Y, et al. Canine model of chronic pancreatitis due to chronic ischemia [J]. Digestion, 1994; 55(2)∶86.
25.	Kataoka K, Sasaki T, Yorizumi H, et al. Pathophsiologic studies of experimental chronic pancreatitis in rats induced by injection of zeinoleic acidlinoleic acid solution into the pancreatic duct [J]. Pancreas, 1998; 16(3)∶289.
26.	Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis [J]. Am J Pathol, 1999; 155(4)∶ 1087.
27.	梁林，馮凱琳，呂維富. 胰腺分裂在慢性胰腺炎病因學中的作用及其發病機制 [J]. 實用放射學雜志, 2000; 16(9)∶522.
28.	Vogelmann R, Ruf D, Wagner M, et al. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGFbeta1 transgenic mouse model [J]. Am J Physiol Gastrointest Liver Physiol, 2001; 280(1)∶ G164.

1. Etemad B, Whitcomb DC. Chronic pancreatitis: diagnosis, classification, and new genetic developments [J]. Gastroenterology, 2001; 120(3)∶682.
2. 佟衛剛，盧實春，胡驥，等. 慢性胰腺炎的外科治療及遠期療效 [J]. 中國普外基礎與臨床雜志, 1999; 6(6)∶347.
3. Ohashi K, Kim JH, Hara H, et al. WBN/Kob rats. A new spontaneously occurring model of chronic pancreatitis [J]. Int J pancreatol, 1990; 6(4)∶231.
4. Su SB, Motoo Y, Xie MJ, et al. Expression of transforming growth factorbeta in spontaneous chronic pancreatitis in the WBN/Kob rat [J]. Dig Dis Sci, 2000; 45(1)∶151.
5. 耿智敏，向國安，韓慶，等. 轉化生長因子β1在膽管愈合過程中的表達及意義 [J]. 中國普外基礎與臨床雜志, 2000; 7(6)∶362.
6. Su SB, Motoo Y, Iovanna JL, et al. Effect of camostat mesilate on the expression of pancreatitisassociated protein (PAP), p8, and cytokines in rat spontaneous chronic pancreatitis [J]. Pancreas, 2001; 23(2)∶134.
7. Su SB, Motoo Y, Xie MJ, et al. Apoptosis in rat spontaneous chronic pancreatis: role of the Fas and Fas ligand system [J]. Dig Dis Sci, 2001; 46(1)∶166.
8. Widdison AL, Alvarez C, Schwarz M, et al. The influence of ethanol on pancreatic blood flow in cats with chronic pancreatitis [J]. Surgery, 1992; 112(2)∶202.
9. Karanjia ND, Widdison AL, Leung F, et al. Compartment syndrome in experimental chronic obstructive pancreatitis: effect of decompressing the main pancreatic duct [J]. Br J Surg, 1994; 81(2)∶ 259.
10. Reber PU, Patel AG, Toyama MT, et al. Feline model of chronic obstructive pancreatitis: effects of acute pancreatic duct decompression on blood flow and interstitial pH [J]. Scand J Gastroenterol, 1999; 34(4)∶439.
11. Toyama MT, Patel AG, Nguyen T, et al. Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis [J]. Ann Surg, 1997; 225(2)∶223.
12. Patel AG, Reber PU, Toyama MT, et al. Effect of pancreaticojejunostomy on fibrosis, pancreatic blood flow, and interstitial pH in chronic pancreatitis: a feline model [J]. Ann Surg, 1999; 230(5)∶672.
13. Reber PU, Patel AG, Lewis MP, et al. Stenting does not decompress the pancreatic duct as effective as surgery in experimental chronic pancreatitis [J]. Surgery, 1998; 124(3)∶561.
14. 李春艷，崔美芝，成曉松，等. 急性胰腺炎動物模型概況 [J]. 哈爾濱醫科大學學報, 1998; 32(4)∶308.
15. 姜永鋒，張延齡. 急性胰腺炎的實驗研究進展 [J]. 國外醫學外科學分冊, 1996; 23(1)∶13.
16. NeuschwanderTetri BA, Burton FR, Presti ME, et al. Repetitive selflimited acute pancreatitis induces pancreatic fibrogenesis in the mouse [J]. Dig Dis Sci, 2000; 45(4)∶665.
17. Murayama KM, Barent BL, Gruber M, et al. Characterization of a novel model of pancreatic fibrosis and acinar atrophy [J]. J Gastrointest Surg, 1999; 3(4)∶418.
18. Miyahara T, Kawabuchi M, Goto M, et al. Morphological study of pancreatic endocrine in an experimental chronic pancreatitis with diabetes induced by stress and cerulein [J]. Ultrastruct Pathol, 1999; 23(3)∶171.
19. Merkord J, Weber H, Sparmann G, et al. The course of pancreatic fibrosis induced by dibutyltin dichloride (DBTC) [J]. Ann N Y Acad Sci, 1999; 880∶231.
20. Merkord J, Weber H, Jonas L, et al. The influence of ethanol on longterm effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats [J]. Hum Exp Toxicol, 1998; 17(3)∶144.
21. Sparmann G, Merkord J, Jaschke A, et al. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride [J]. Gasteroenterology, 1997; 112(5)∶1664.
22. Sparmann G, Behrend S, Merkord J, et al. Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride [J]. Dig Dis Sci, 2001; 46(8)∶1647.
23. Freiburghaus AU, Redha F, Ammann RW. Does actue pancreatitis progress to chronic pancreatitis? A microvascular pancreatitis model in the rat [J]. Pancreas, 1995; 11(4)∶374.
24. Tanaka T, Ichiba Y, Miura Y, et al. Canine model of chronic pancreatitis due to chronic ischemia [J]. Digestion, 1994; 55(2)∶86.
25. Kataoka K, Sasaki T, Yorizumi H, et al. Pathophsiologic studies of experimental chronic pancreatitis in rats induced by injection of zeinoleic acidlinoleic acid solution into the pancreatic duct [J]. Pancreas, 1998; 16(3)∶289.
26. Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis [J]. Am J Pathol, 1999; 155(4)∶ 1087.
27. 梁林，馮凱琳，呂維富. 胰腺分裂在慢性胰腺炎病因學中的作用及其發病機制 [J]. 實用放射學雜志, 2000; 16(9)∶522.
28. Vogelmann R, Ruf D, Wagner M, et al. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGFbeta1 transgenic mouse model [J]. Am J Physiol Gastrointest Liver Physiol, 2001; 280(1)∶ G164.

《中國普外基礎與臨床雜志》

慢性胰腺炎動物模型研究進展

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《中國普外基礎與臨床雜志》

慢性胰腺炎動物模型研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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