生長抑素類似物對肝癌細胞凋亡及c-myc蛋白表達的影響_《中國普外基礎與臨床雜志》

作者：

張燕玲 , 張正

四川大學華西醫院老年科（成都610041）;

關鍵詞：

生長抑素類似物人肝癌細胞SMMC-7721凋亡 c-myc蛋白表達

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目的探討生長抑素類似物8肽（SS8）對人原發性肝癌細胞凋亡和cmyc蛋白表達的影響。方法體外培養肝癌細胞SMMC7721，用10 μg/ml SS8處理后，流式細胞儀檢測肝癌細胞凋亡率和cmyc蛋白的表達。結果與對照組相比，SS8使實驗組S期和G2/M期細胞數減少、G0/G1期細胞數增加，兩組細胞的凋亡率分別為6.1%和14.2%，差異有顯著性意義（P＜0.05）。經SS8作用24 h后，實驗組cmyc蛋白表達水平為0.833±0.035，與對照組相比差異無顯著性意義（P＞0.10），而在SS8作用48、72、96、120和144 h后，實驗組cmyc蛋白表達水平分別為0.818±0.04、0.721±0.029、0.669±0.026、0.648±0.045和0.642±0.028，較對照組顯著降低（P＜0.05）。結論SS8有誘導肝癌細胞SMMC7721凋亡和降低cmyc蛋白表達的作用。

引用本文： 張燕玲,張正. 生長抑素類似物對肝癌細胞凋亡及c-myc蛋白表達的影響. 中國普外基礎與臨床雜志, 2003, 10(1): 25-27. doi: 復制

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《中國普外基礎與臨床雜志》

生長抑素類似物對肝癌細胞凋亡及c-myc蛋白表達的影響

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《中國普外基礎與臨床雜志》

生長抑素類似物對肝癌細胞凋亡及c-myc蛋白表達的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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