血管內皮細胞在動脈粥樣硬化中的損傷機理_《中國普外基礎與臨床雜志》

作者：

趙泉 ¹ , 鄧靖宇 ² , 羅開元 ¹ , 時德 ²

1.云南省第二人民醫院普外科（昆明650021）;;
2.重慶醫科大學附屬第一醫院血管外科（重慶400016）;

關鍵詞：

動脈粥樣硬化血管內皮細胞粘附分子

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的探討血管內皮細胞在動脈粥樣硬化形成過程中的損傷機理。方法復習相關文獻，對有關進展進行總結分析。結果各種致病因素造成細胞因子生成增多，激活了控制細胞粘附分子表達的核因子-κB，進而使細胞粘附分子表達增強，促進單核細胞血管內皮細胞為主的粘附形成增多，釋放大量炎性介質(氧自由基及蛋白酶等)，不僅直接損傷血管內皮細胞，并可以通過免疫機理使大量單核細胞及中性粒細胞與血管內皮細胞粘附結合，進一步損傷血管內皮細胞。同時，受損的血管內皮細胞由于膜結構的改變引起抗動脈抗體的產生以致補體系統被激活而加重了血管內皮細胞的損傷，也促進了動脈粥樣硬化的發生和發展。結論正確認識血管內皮細胞在動脈粥樣硬化發生、發展過程中受損機理，對于動脈粥樣硬化的防治具有重要意義。

引用本文： 趙泉,鄧靖宇,羅開元,時德. 血管內皮細胞在動脈粥樣硬化中的損傷機理. 中國普外基礎與臨床雜志, 2004, 11(4): 325-327. doi: 復制

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1. Reiner Z, TedeschiReiner E. New information on the pathophysiology of atherosclerosis [J]. Lijec Vjesn, 2001; 123(1-2)∶26.
2. Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis [J]. Circulation, 1997; 95(4)∶1062.
3. Colome C, MartinezGonzalez J, Vidal F, et al. Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A [J].Atherosclerosis, 2000; 149(2)∶295.
4. Cockerill GW, Saklatvala J, Ridley SH, et al. Highdensity lipoproteins differentially modulate cytokineinduced expression of Eselectin and cyclooxygenase2 [J]. Arterioscler Thromb Vasc Biol, 1999; 19(4)∶910.
5. Khan BV, Harrison DG, Olbrych MT, et al. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redoxsensitive transcriptional events in human vascular endothelial cells [J]. Proc Natl Acad Sci USA, 1996; 93(17)∶9114.
6. Keck C, Herchenbach D, Pfisterer J, et al. Effects of 17betaestradiol and progesterone on interleukin6 production and proliferation of human umbilical vein endothelial cells [J]. Exp Clin Endocrinol Diabetes, 1998; 106(4)∶334.
7. Walsh BA, Mullick AE, Banka CE, et al. 17betaestradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation [J]. J Lipid Res, 2000; 41(1)∶134.
8. Spyridopoulos I, Sullivan AB, Kearney M, et al. Estrogen receptor mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor [J]. Circulation, 1997； 95(6)∶1505.
9. Best PJ, Berger PB, Miller VM, et al. The effect of estrogen replacement therapy on plasma nitric oxide and endothelin1 levels in postmenopausal women [J]. Ann Intern Med, 1998; 128(4)∶285.
10. Simoncini T, Maffei S, Basta G, et al. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule1 expression by different transcriptional mechanisms [J]. Circ Res, 2000; 87(1)∶19.
11. CaulinGlaser T, Farrell WJ, Pfau SE, et al. Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease [J]. J Am Coll Cardiol, 1998; 31(7)∶1555.
12. Manduteanu L, Voinea M, Serban G, et al. High glucose induces enhanced monocyte adhesion to valvular endothelial cells via a mechanism involving ICAM1, VCAM1 and CD18 [J]. Endothelium, 1999; 6(4)∶315.
13. Kado S, Nagata N. Circulating intercellular adhesion molecule1, vascular cell adhesion molecule1, and Eselectin in patients with type 2 diabetes mellitus [J]. Diabetes Res Clin Pract, 1999; 46(2)∶143.
14. Ribau JC, Hadcock SJ, Teoh K, et al. Endothelial adhesion molecule expression is enhanced in the aorta and internal mammary artery of diabetic patients [J]. J Surg Res, 1999; 85(2)∶225.
15. Kol A, Bourcier T, Lichtman AH, et al. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages [J].J Clin Invest， 1999; 103(4)∶571.
16. Shen Y, Rattan V, Sultana C, et al. Cigarette smoke condensateinduced adhesion molecule expression and transendothelial migration of monocytes [J]. Am J Physiol, 1996; 270(5 Pt 2)∶H1624.
17. Rosenbaum J, Pottinger BE, Woo P, et al. Measurement and charactersation of circulating antiendothelial cell IgG connective tissue diseases [J]. Clin Exp Immunol, 1998; 72(3)∶450.
18. Kawana S. The membrane attack complex of complement alters the membrane integrity of cultured endothelial cells: a possible pathophysiology for immune complex vasculitis [J]. Acta Derm Venereol, 1996; 76(1)∶13.
19. Miyagawa S, Shirakura R, Mikata S, et al. Functional feature of C5b8step lysis of swine endothelial cell transfected CD59 [J]. Transplant Proc, 1996; 28(2)∶597.
20. McCurry KR, Kooyman DL, Diamond LE, et al. Transgenic expression of human complement regulatory proteins in mice results in diminished complement deposition during organ xenoperfusion [J]. Transplantation, 1995; 59(8)∶1177.
21. Li W, Tada T, Miwa T, et al. mRNA expression of complement components and regulators in rat arterial smooth muscle cells [J]. Microbiol Immunol, 1999; 43(6)∶585.
22. Seifert PS, Roth I, Schmiedt W, et al. CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b9 attack, in human atherosclerotic lesions [J]. Atherosclerosis, 1992; 96(2-3)∶135.

《中國普外基礎與臨床雜志》

血管內皮細胞在動脈粥樣硬化中的損傷機理

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《中國普外基礎與臨床雜志》

血管內皮細胞在動脈粥樣硬化中的損傷機理

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料