高強度聚焦超聲治療對肝癌患者外周血AFP mRNA的影響_《中國普外基礎與臨床雜志》

作者：

李富宇 , 劉紅 , 龍泉伊 , 蔣力生 , 許瑞華

四川大學華西醫院普外科、海扶治療中心（成都610041）;

關鍵詞：

高強度聚焦超聲肝癌血道播散AFP mRNA

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目的探討高強度聚焦超聲治療對肝癌細胞血道播散的影響。方法應用NestedRTPCR技術檢測19例患者高強度聚焦超聲治療前、后外周血AFP mRNA的表達，觀察其對肝癌細胞血道播散的影響。結果①高強度聚焦超聲治療前，19例肝癌患者外周血檢出AFP mRNA表達者11例（57.9%），良性疾病對照組均未檢出。治療前AFP mRNA表達陽性率與血清AFP水平、腫瘤直徑、門靜脈癌栓、遠處轉移等臨床參數明顯相關(P＜0.05)。②余8例治療前AFP mRNA表達陰性者，有2例于術后即刻轉為陽性，其中1例于72 h后又復轉為陰性； 19例患者于治療后1周時其AFP mRNA表達陽性率（31.6%）低于治療前，但差異無統計學意義（P gt;0.05）。③治療后1周時，腫瘤直徑≤8 cm者AFP mRNA表達陽性率低于直徑 gt;8 cm者(P＜0.05)。結論高強度聚焦超聲治療可能會降低肝癌的血道播散，特別是對于腫瘤直徑≤8 cm的肝癌患者，療效較好。

引用本文： 李富宇,劉紅,龍泉伊,蔣力生,許瑞華. 高強度聚焦超聲治療對肝癌患者外周血AFP mRNA的影響. 中國普外基礎與臨床雜志, 2004, 11(3): 247-249. doi: 復制

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1. Farmer DG, Rosove MH, Shaked A, et al. Current treatment modalities for hepatocellular carcinoma [Ｊ]. Ann Surg, 1994; 219(3)∶ 236.
2. Yang R, Reilly CR, Rescorla FJ, et al. Highintensity focused ultrasound in the treatment of experimental liver cancer [Ｊ]. Arch Surg, 1991; 126(8)∶1002.
3. Oosterhof GO, Cornel EB, Smits GA, et al. Influence of highintensity focused ultrasound on the development of metastases [Ｊ]. Eur Urol, 1997; 32(1)∶91.
4. Komeda T, Fukuda Y, Sando T, et al. Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood [Ｊ]. Cancer, 1995; 75(9)∶2214.
5. Wang L, Tang ZY, Qin LX, et al. Highdose and longterm therapy with interferonalfa inhibits tumor growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential [Ｊ]. Hepatology, 2000; 32(1)∶43.
6. Matsumura M, Niwa Y, Kato N, et al. Detection of alphafetoprotein mRNA, an indicator of hematogenous spreading hepatocellular carcinoma, in the circulation: a possible predictor of metastatic hepatocellular carcinoma [Ｊ]. Hepatology, 1994; 20(6)∶1418.
7. Prat F, Centarti M, Sibille A, et al. Extracorporeal highintensity focused ultrasound for VX2 liver tumors in the rabbit [Ｊ]. Hepatology, 1995; 21(3)∶832.

《中國普外基礎與臨床雜志》

高強度聚焦超聲治療對肝癌患者外周血AFP mRNA的影響

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《中國普外基礎與臨床雜志》

高強度聚焦超聲治療對肝癌患者外周血AFP mRNA的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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