MELD評分系統在肝移植中的應用和意義_《中國普外基礎與臨床雜志》

作者：

謝建國 , 嚴律南

四川大學華西醫院肝移植中心（成都610041）;;
通訊作者：嚴律南;

關鍵詞：

終末期肝病模型肝移植器官分配

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

【摘要】目的討論終末期肝病模型（MELD）的產生與發展，評價對肝移植的影響。
方法回顧性分析MELD在肝移植應用中的有關文獻。
結果 MELD廣泛應用于預測和評定終末期肝病的嚴重程度及患者等待肝移植期間死亡危險度，以決定器官分配的優先順序。
結論 MELD為新的評分系統，可減少患者等待肝移植的時間，客觀地、精確地預測終末期肝病患者的短期生存率和死亡危險度，是較為理想的器官分配評分系統。

引用本文： 謝建國,嚴律南. MELD評分系統在肝移植中的應用和意義. 中國普外基礎與臨床雜志, 2005, 12(6): 634-636. doi: 復制

1.	Testa R, Valente U, Risso D, et al. Can the MEGX test and serum bile acids improve the prognostic ability of ChildPugh’s score in liver cirrhosis? [J]. Eur J Gastroenterol Hepatol, 1999; 11(5)559.
2.	Malinchoc M, Kamath PS, Gordon FD, et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts [J]. Hepatology, 2000; 31(4)864.
3.	Chalasani N, Kahi CJ, Francois F, et al. Mayo clinic endstage liver disease model (MELD) for predicting patient outcomes following acute variceal bleeding [J]. Hepatology, 2001； 34∶345A.
4.	Carithers RL Jr. Liver transplantation. American Association for the Study of Liver Diseases [J]. Liver Transpl, 2000; 6(1)122.
5.	Abouassi SG, Mihas AA, Williams LM, et al. MELD and CTP scores are equivalent predictors of mortality in cirrhotic veterans referred for orthotopic liver transplantation (OLT) [J]. Hepatology, 2001; 34207A.
6.	Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with endstage liver disease [J]. Hepatology, 2001; 33(2)464.
7.	Bambha K, Kim WR, Kremers WK, et al. Predicting survival among patients listed for liver transplantation: an assessment of serial MELD measurements [J]. Am J Transplant, 2004; 4(11)1798.
8.	Wiesner RH, McDiarmid SV, Kamath PS, et al. MELD and PELD: application of survival models to liver allocation [J]. Liver Transpl, 2001; 7(7)567.
9.	Botta F, Giannini E, Romagnoli P, et al. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study [J]. Gut, 2003; 52(1)134.
10.	Freeman RB Jr, Wiesner RH, Roberts JP, et al. Improving liver allocation: MELD and PELD [J]. Am J Transplant, 2004; 4(Suppl 9)114.
11.	Freeman RB, Wiesner RH, Edwards E, et al. Results of the first year of the new liver allocation plan [J]. Liver Transpl, 2004; 10(1)7.
12.	Jacob M, Copley LP, Lewsey JD, et al. Pretransplant MELD score and post liver transplantation survival in the UK and Ireland [J]. Liver Transpl, 2004; 10(7)903.
13.	Onaca NN, Levy MF, Sanchez EQ, et al. A correlation between the pretransplantation MELD score and mortality in the first two years after liver transplantation [J]. Liver Transpl, 2003; 9(2)117.
14.	Bambha K, Kim WR, Kremers WK, et al. Predicting survival among patients listed for liver transplantation: an assessment of serial MELD measurements [J]. Am J Transplant, 2004; 4(11)1798.
15.	Wiesner RH, Freeman RB, Mulligan DC. Liver transplantation for hepatocellular cancer: the impact of the MELD allocation policy [J]. Gastroenterology, 2004; 127(5 Suppl 1)S261.
16.	Sharma P, Balan V, Hernandez JL, et al. Liver transplantation for hepatocellular carcinoma: the MELD impact [J]. Liver Transpl, 2004; 10(1)36.
17.	Yao FY, Bass NM, Ascher NL, et al. Liver transplantation for hepatocellular carcinoma: lessons from the first year under the Model of EndStage Liver Disease (MELD) organ allocation policy [J]. Liver Transpl, 2004; 10(5)621.
18.	Olthoff KM, Brown RS Jr, Delmonico FL, et al. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA [J]. Liver Transpl, 2004; 10(10 Suppl 2)A6.
19.	Wang VS, Saab S. Liver transplantation in the era of model for endstage liver disease [J]. Liver Int, 2004; 24(1)1.
20.	Trotter JF, Brimhall B, Arjal R, et al. Specific laboratory methodologies achieve higher model for endstage liver disease (MELD) scores for patients listed for liver transplantation [J]. Liver Transpl, 2004; 10(8)995.
21.	McCaughan GW, Strasser SI. To MELD or not to MELD? [J]. Hepatology， 2001; 34(1)215.
22.	Heuman DM, AbouAssi SG, Habib A, et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death [J]. Hepatology， 2004; 40(4)802.
23.	Freeman RB. Mathematical models and behavior: assessing delta MELD for liver allocation [J]. Am J Transplant， 2004; 4(11)1735.

1. Testa R, Valente U, Risso D, et al. Can the MEGX test and serum bile acids improve the prognostic ability of ChildPugh’s score in liver cirrhosis? [J]. Eur J Gastroenterol Hepatol, 1999; 11(5)559.
2. Malinchoc M, Kamath PS, Gordon FD, et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts [J]. Hepatology, 2000; 31(4)864.
3. Chalasani N, Kahi CJ, Francois F, et al. Mayo clinic endstage liver disease model (MELD) for predicting patient outcomes following acute variceal bleeding [J]. Hepatology, 2001； 34∶345A.
4. Carithers RL Jr. Liver transplantation. American Association for the Study of Liver Diseases [J]. Liver Transpl, 2000; 6(1)122.
5. Abouassi SG, Mihas AA, Williams LM, et al. MELD and CTP scores are equivalent predictors of mortality in cirrhotic veterans referred for orthotopic liver transplantation (OLT) [J]. Hepatology, 2001; 34207A.
6. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with endstage liver disease [J]. Hepatology, 2001; 33(2)464.
7. Bambha K, Kim WR, Kremers WK, et al. Predicting survival among patients listed for liver transplantation: an assessment of serial MELD measurements [J]. Am J Transplant, 2004; 4(11)1798.
8. Wiesner RH, McDiarmid SV, Kamath PS, et al. MELD and PELD: application of survival models to liver allocation [J]. Liver Transpl, 2001; 7(7)567.
9. Botta F, Giannini E, Romagnoli P, et al. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study [J]. Gut, 2003; 52(1)134.
10. Freeman RB Jr, Wiesner RH, Roberts JP, et al. Improving liver allocation: MELD and PELD [J]. Am J Transplant, 2004; 4(Suppl 9)114.
11. Freeman RB, Wiesner RH, Edwards E, et al. Results of the first year of the new liver allocation plan [J]. Liver Transpl, 2004; 10(1)7.
12. Jacob M, Copley LP, Lewsey JD, et al. Pretransplant MELD score and post liver transplantation survival in the UK and Ireland [J]. Liver Transpl, 2004; 10(7)903.
13. Onaca NN, Levy MF, Sanchez EQ, et al. A correlation between the pretransplantation MELD score and mortality in the first two years after liver transplantation [J]. Liver Transpl, 2003; 9(2)117.
14. Bambha K, Kim WR, Kremers WK, et al. Predicting survival among patients listed for liver transplantation: an assessment of serial MELD measurements [J]. Am J Transplant, 2004; 4(11)1798.
15. Wiesner RH, Freeman RB, Mulligan DC. Liver transplantation for hepatocellular cancer: the impact of the MELD allocation policy [J]. Gastroenterology, 2004; 127(5 Suppl 1)S261.
16. Sharma P, Balan V, Hernandez JL, et al. Liver transplantation for hepatocellular carcinoma: the MELD impact [J]. Liver Transpl, 2004; 10(1)36.
17. Yao FY, Bass NM, Ascher NL, et al. Liver transplantation for hepatocellular carcinoma: lessons from the first year under the Model of EndStage Liver Disease (MELD) organ allocation policy [J]. Liver Transpl, 2004; 10(5)621.
18. Olthoff KM, Brown RS Jr, Delmonico FL, et al. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA [J]. Liver Transpl, 2004; 10(10 Suppl 2)A6.
19. Wang VS, Saab S. Liver transplantation in the era of model for endstage liver disease [J]. Liver Int, 2004; 24(1)1.
20. Trotter JF, Brimhall B, Arjal R, et al. Specific laboratory methodologies achieve higher model for endstage liver disease (MELD) scores for patients listed for liver transplantation [J]. Liver Transpl, 2004; 10(8)995.
21. McCaughan GW, Strasser SI. To MELD or not to MELD? [J]. Hepatology， 2001; 34(1)215.
22. Heuman DM, AbouAssi SG, Habib A, et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death [J]. Hepatology， 2004; 40(4)802.
23. Freeman RB. Mathematical models and behavior: assessing delta MELD for liver allocation [J]. Am J Transplant， 2004; 4(11)1735.

《中國普外基礎與臨床雜志》

MELD評分系統在肝移植中的應用和意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

《中國普外基礎與臨床雜志》

MELD評分系統在肝移植中的應用和意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料