Seprase表達與人結直腸癌臨床病理特征的關系_《中國普外基礎與臨床雜志》

作者：

張雪峰 ¹ , 金鑫 ² , 吳國強 ¹ , 王希澤 ¹ , 李謹 ¹ , 宗修錕 ¹

1.沈陽軍區總醫院普通外科（沈陽110016）;;
2.中國醫科大學藥理系（沈陽110001）;

關鍵詞：

Seprase 結直腸癌轉移免疫組織化學

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目的探討Seprase表達與結直腸癌臨床病理特征間的關系。
方法分別采用免疫組織化學、免疫印跡及半定量免疫組織化學方法對50例結直腸癌患者腫瘤標本中Seprase的表達進行了檢測，并對Seprase的表達與其臨床病理特征的關系進行了分析。
結果Seprase在腫瘤細胞和鄰近基質細胞中均有表達，Seprase蛋白在腫瘤組織中的表達明顯高于正常結直腸組織（P＜0.01），其表達與腫瘤Dukes分期及淋巴結轉移有關。
結論Seprase在結直腸癌中高表達與腫瘤Dukes分期及淋巴結轉移有關。

引用本文： 張雪峰,金鑫,吳國強,王希澤,李謹,宗修錕. Seprase表達與人結直腸癌臨床病理特征的關系. 中國普外基礎與臨床雜志, 2006, 13(1): 89-93. doi: 復制

1.	Ariga N, Sato E, Ohuchi N, et al. Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast [Ｊ]. Int J Cancer, 2001; 95(1)∶67.
2.	Aoyama A, Chen WT. A 170kDa membranebound protease is associated with the expression of invasiveness by human malignant melanoma cells [Ｊ]. Proc Natl Acad Sci USA， 1990; 87(21)∶8296.
3.	Monsky WL, Lin CY, Aoyama A, et al. A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells [Ｊ]. Cancer Res， 1994; 54(21)∶5702.
4.	Papadopoulou S, Scorilas A, Arnogianaki N, et al. Expression of gelatinaseA (MMP2) in human colon cancer and normal colon mucosa [Ｊ]. Tumour Biol， 2001; 22(6)∶383.
5.	Heppner KJ, Matrisian LM, Jensen RA, et al. Expression of most matrix metalloproteinase family members in breast cancer represents a tumorinduced host response [Ｊ]. Am J Pathol， 1996; 149(1)∶273.
6.	Ito A, Nakajima S, Sasaguri Y, et al. Coculture of human breast adenocarcinoma MCF7 cells and human dermal fibroblasts enhances the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts [Ｊ]. Br J Cancer， 1995; 71(5)∶1039.
7.	Scanlan MJ, Raj BK, Calvo B, et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers [Ｊ]. Proc Natl Acad Sci USA， 1994; 91(12)∶5657.
8.	Harvey SR, Sait SN, Xu Y, et al. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization [Ｊ]. Am J Pathol, 1999; 155(4)∶1115.
9.	Okada K, Chen WT, Iwasa S, et al. Seprase, a membranetype serine protease, has different expression patterns in intestinal and diffusetype gastric cancer [Ｊ]. Oncology, 2003; 65(4)∶363.
10.	Sato T, Nishimura G, Yonemura Y, et al. Association of immunohistochemical detection of urokinasetype plasminogen activator with metastasis and prognosis in colorectal cancer [Ｊ]. Oncology, 1995; 52(4)∶347.

1. Ariga N, Sato E, Ohuchi N, et al. Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast [Ｊ]. Int J Cancer, 2001; 95(1)∶67.
2. Aoyama A, Chen WT. A 170kDa membranebound protease is associated with the expression of invasiveness by human malignant melanoma cells [Ｊ]. Proc Natl Acad Sci USA， 1990; 87(21)∶8296.
3. Monsky WL, Lin CY, Aoyama A, et al. A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells [Ｊ]. Cancer Res， 1994; 54(21)∶5702.
4. Papadopoulou S, Scorilas A, Arnogianaki N, et al. Expression of gelatinaseA (MMP2) in human colon cancer and normal colon mucosa [Ｊ]. Tumour Biol， 2001; 22(6)∶383.
5. Heppner KJ, Matrisian LM, Jensen RA, et al. Expression of most matrix metalloproteinase family members in breast cancer represents a tumorinduced host response [Ｊ]. Am J Pathol， 1996; 149(1)∶273.
6. Ito A, Nakajima S, Sasaguri Y, et al. Coculture of human breast adenocarcinoma MCF7 cells and human dermal fibroblasts enhances the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts [Ｊ]. Br J Cancer， 1995; 71(5)∶1039.
7. Scanlan MJ, Raj BK, Calvo B, et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers [Ｊ]. Proc Natl Acad Sci USA， 1994; 91(12)∶5657.
8. Harvey SR, Sait SN, Xu Y, et al. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization [Ｊ]. Am J Pathol, 1999; 155(4)∶1115.
9. Okada K, Chen WT, Iwasa S, et al. Seprase, a membranetype serine protease, has different expression patterns in intestinal and diffusetype gastric cancer [Ｊ]. Oncology, 2003; 65(4)∶363.
10. Sato T, Nishimura G, Yonemura Y, et al. Association of immunohistochemical detection of urokinasetype plasminogen activator with metastasis and prognosis in colorectal cancer [Ｊ]. Oncology, 1995; 52(4)∶347.

《中國普外基礎與臨床雜志》

Seprase表達與人結直腸癌臨床病理特征的關系

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《中國普外基礎與臨床雜志》

Seprase表達與人結直腸癌臨床病理特征的關系

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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