熱休克蛋白70疫苗在消化道腫瘤研究中的進展_《中國普外基礎與臨床雜志》

作者：

劉勝 , 應敏剛

福建醫科大學教學醫院福建省腫瘤醫院 (福州350014);

關鍵詞：

熱休克蛋白70 疫苗消化道腫瘤

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　綜述熱休克蛋白70（heat shock protein 70，HSP70）疫苗在消化道腫瘤中的研究進展。
方法　對近年來的相關文獻進行分析。
結果　HSP70能與腫瘤特異性抗原結合，形成HSP70-多肽復合物；它作為“分子伴侶”參與腫瘤免疫作用，激活機體特異和非特異免疫反應。
結論　HSP70的應用在消化道腫瘤的預防和治療中顯示出誘人的前景。

引用本文： 劉勝,應敏剛. 熱休克蛋白70疫苗在消化道腫瘤研究中的進展. 中國普外基礎與臨床雜志, 2007, 14(6): 728-730. doi: 復制

1.	Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells [J]. Cancer Res, 2000; 60(11)∶2942.
2.	Ozdemirler Erata G, Kanbaqli O, Durlanik O, et al. Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas [J]. Jpn J Clin Oncol， 2005; 35(2)∶74.
3.	Ueda G, Tamura Y, Hirai I, et al. Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity [J]. Cancer Sci， 2004; 95(3)∶248.
4.	Maier T, Tun-Kyi A, Tassis A, et al. Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells [J]. Blood， 2003; 102(7)∶2338.
5.	Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells [J]. Cell Growth Differ， 2001; 12(8)∶419.
6.	王小平, 劉國貞, 宋愛利, 等. 人肝癌組織熱休克蛋白70的表達 [J]. 首都醫科大學學報, 2004; 25(2)∶186.
7.	李春梅, 劉志峰, 張紅緒, 等. Hsp70和PCNA在NIH小鼠前胃癌變過程中的表達及意義 [J]. 細胞與分子免疫學雜志, 2004; 20(5)∶625.
8.	Wang XP, Qiu FR, Liu GZ, et al. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma [J]. World J Gastroenterol， 2005; 11(7)∶1056.
9.	Massé D, Ebstein F, Bougras G, et al. Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy [J]. Int J Cancer， 2004; 111(4)∶575.
10.	Massa C, Melani C, Colombo MP. Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens [J]. Cancer Res， 2005; 65(17)∶7942.
11.	Krause SW, Gastpar R, Andreesen R, et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase Ⅰ trial [J]. Clin Cancer Res， 2004; 10(11)∶3699.
12.	Wan T, Zhou X, Chen G, et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant [J]. Blood， 2004; 103(5)∶1747.
13.	史斌, 陳以娟, 王申五, 等. 熱休克蛋白-樹突狀細胞疫苗對慢性髓系白血病免疫治療作用的體外研究 [J]. 中華內科雜志, 2004; 43(5)∶380.
14.	錢世鹍, 閔軍, 褚忠華, 等. 熱休克蛋白對樹突狀細胞成熟的影響研究 [J]. 中國病理生理雜志, 2004; 20(7)∶1190.
15.	萬敏, 張培因, 王宣軍, 等. 熱休克蛋白融合蛋白對人樹突狀細胞分化成熟的刺激作用 [J]. 吉林大學學報（醫學版）, 2004; 30(6)∶835.
16.	Srivastava PK, MR Das. The serologically unique cell surface of zajdela ascitic hepatoma is also it tumor-associated transplantation antigen [J]. Int J Cancer, 1984; 33(3)∶417.
17.	黃波, 馮作化, 張桂梅. Hsp70-腫瘤抗原肽復合物修飾的DC疫苗體內外特異性抗瘤作用 [J]. 中國免疫學雜志, 2002; 18(9)∶614.
18.	陳代雄, 蘇艷蓉, 錢振超. HSP70-腫瘤肽對小鼠肝癌的抗腫瘤免疫效應 [J]. 中國腫瘤生物治療雜志, 2002; 9(3)∶163.
19.	袁慶文, 劉學政, 劉學農, 等. 胃癌Hsp70-肽復合物致敏樹突狀細胞抗腫瘤作用的研究 [J]. 江西醫學院學報, 2005; 45(3)∶1.
20.	華贇鵬, 梁力建, 黃潔夫. 熱休克蛋白與肝缺血再灌注損傷 [J]. 中國普外基礎與臨床雜志, 2000; 7(4)∶269.
21.	Todryk SM, Eaton J, Birchall L, et al. Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity [J]. Cancer Immunol Immunother， 2004; 53(4)∶323.
22.	Nylandsted J, Wick W, Hirt UA, et al. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion [J]. Cancer Res， 2002; 62(24)∶7139.
23.	邱健, 李國威, 隋延仿, 等. 熱休克腫瘤細胞抗原負載的樹突狀細胞瘤苗對原位接種結腸腫瘤的免疫預防作用 [J]. 世界華人消化雜志, 2005; 13(5)∶635.

1. 　Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells [J]. Cancer Res, 2000; 60(11)∶2942.
2. 　Ozdemirler Erata G, Kanbaqli O, Durlanik O, et al. Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas [J]. Jpn J Clin Oncol， 2005; 35(2)∶74.
3. 　Ueda G, Tamura Y, Hirai I, et al. Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity [J]. Cancer Sci， 2004; 95(3)∶248.
4. 　Maier T, Tun-Kyi A, Tassis A, et al. Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells [J]. Blood， 2003; 102(7)∶2338.
5. 　Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells [J]. Cell Growth Differ， 2001; 12(8)∶419.
6. 　王小平, 劉國貞, 宋愛利, 等. 人肝癌組織熱休克蛋白70的表達 [J]. 首都醫科大學學報, 2004; 25(2)∶186.
7. 　李春梅, 劉志峰, 張紅緒, 等. Hsp70和PCNA在NIH小鼠前胃癌變過程中的表達及意義 [J]. 細胞與分子免疫學雜志, 2004; 20(5)∶625.
8. 　Wang XP, Qiu FR, Liu GZ, et al. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma [J]. World J Gastroenterol， 2005; 11(7)∶1056.
9. 　Massé D, Ebstein F, Bougras G, et al. Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy [J]. Int J Cancer， 2004; 111(4)∶575.
10. 　Massa C, Melani C, Colombo MP. Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens [J]. Cancer Res， 2005; 65(17)∶7942.
11. 　Krause SW, Gastpar R, Andreesen R, et al. Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase Ⅰ trial [J]. Clin Cancer Res， 2004; 10(11)∶3699.
12. 　Wan T, Zhou X, Chen G, et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant [J]. Blood， 2004; 103(5)∶1747.
13. 　史斌, 陳以娟, 王申五, 等. 熱休克蛋白-樹突狀細胞疫苗對慢性髓系白血病免疫治療作用的體外研究 [J]. 中華內科雜志, 2004; 43(5)∶380.
14. 　錢世鹍, 閔軍, 褚忠華, 等. 熱休克蛋白對樹突狀細胞成熟的影響研究 [J]. 中國病理生理雜志, 2004; 20(7)∶1190.
15. 　萬敏, 張培因, 王宣軍, 等. 熱休克蛋白融合蛋白對人樹突狀細胞分化成熟的刺激作用 [J]. 吉林大學學報（醫學版）, 2004; 30(6)∶835.
16. 　Srivastava PK, MR Das. The serologically unique cell surface of zajdela ascitic hepatoma is also it tumor-associated transplantation antigen [J]. Int J Cancer, 1984; 33(3)∶417.
17. 　黃波, 馮作化, 張桂梅. Hsp70-腫瘤抗原肽復合物修飾的DC疫苗體內外特異性抗瘤作用 [J]. 中國免疫學雜志, 2002; 18(9)∶614.
18. 　陳代雄, 蘇艷蓉, 錢振超. HSP70-腫瘤肽對小鼠肝癌的抗腫瘤免疫效應 [J]. 中國腫瘤生物治療雜志, 2002; 9(3)∶163.
19. 　袁慶文, 劉學政, 劉學農, 等. 胃癌Hsp70-肽復合物致敏樹突狀細胞抗腫瘤作用的研究 [J]. 江西醫學院學報, 2005; 45(3)∶1.
20. 　華贇鵬, 梁力建, 黃潔夫. 熱休克蛋白與肝缺血再灌注損傷 [J]. 中國普外基礎與臨床雜志, 2000; 7(4)∶269.
21. 　Todryk SM, Eaton J, Birchall L, et al. Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity [J]. Cancer Immunol Immunother， 2004; 53(4)∶323.
22. 　Nylandsted J, Wick W, Hirt UA, et al. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion [J]. Cancer Res， 2002; 62(24)∶7139.
23. 　邱健, 李國威, 隋延仿, 等. 熱休克腫瘤細胞抗原負載的樹突狀細胞瘤苗對原位接種結腸腫瘤的免疫預防作用 [J]. 世界華人消化雜志, 2005; 13(5)∶635.

《中國普外基礎與臨床雜志》

熱休克蛋白70疫苗在消化道腫瘤研究中的進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

熱休克蛋白70疫苗在消化道腫瘤研究中的進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料