- The S econd Department of General S urgery , The S econd A f f i l icated Hos pi tal of N orthern S ichuan Medical College,Mianyang 404 Hospital , Mianyang 621000 , China;
Objective To review the research advancement of multimodal therapy for advanced gast ric carcinoma. Methods The literatures on multimodal therapy for advanced gastric carcinoma in recent years were collected and reviewed. Results The multimodal therapy , such as preoperative chemotherapy , preoperative adjuvant chemoradiotherapy , preoperative interventional chemoradiotherapy for advanced gast ric carcinoma was effective because it could increase the rate of R0 resection for the patients with advanced gastric carcinoma. And it can decrease the mortality rate after operation , extend the overall survival time and improve patients’life quality. Conclusion Multimodal therapy is a promising method for the treatment of advanced gastric carcinoma and it should be further developed.
Citation： HE Yunsheng,J IANG Huaiwu.. Current Status of Multimodal Therapy for A vanced Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(1): 31-35. doi: Copy
Copyright ? the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. | <>[1]Higuchi K,Phan A,Ajani JA.Gastric cancer:advances in adjuvant and adjunct therapy[J].Curr Treat Options Oncol,2003; 4(5)∶413. |
| 2. | 劉福坤,姚學權.胃癌的新輔助化療[J].中國普外基礎與臨床雜志,2006; 13(1)∶18. |
| 3. | Cheong JH,Shen JY,Song CS,et al.Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer[J].Ann Surg Oncol,2007; 14(1)∶61. |
| 4. | 詹文華.胃癌手術前化療的研究現狀[J].中華胃腸外科雜志,2005; 8(5)∶471. |
| 5. | Frei E 3rd.Clinical cancer research:an embattled species[J].Cancer,1982; 50(10)∶1979. |
| 6. | Cunningham D,Allum WH,Stenning SP,et al.Perioperative chemotherapy in operable gastric and lower oesophageal cancer:final results of a randomized controlled trial (the MAGIC trial,ISRCTN 93793971)[J].Proc Am Soc Clin Oncol,2005; 23∶308s. |
| 7. | Wilke H,Preusser P,Fink U,et al.Preoperative chemotherapy in locally advanced and nonresectable gastric cancer:a phase Ⅱ study with etoposide,doxorubicin,and cisplatin[J].J Clin Oncol,1989; 7(9)∶1318. |
| 8. | Yamaguchi K,Nakagawa S,Yabusaki H,et al.A case of advanced gastric cancer responding remarkably to paclitaxel + low-dose FP therapy in a neoadjuvant setting[J].Gan To Kagaku Ryoho,2006; 33(8)∶1163. |
| 9. | Persiani R,D’Ugo D,Biondi A,et al.T-downstaging after neoadjuvant chemotherapy in locally advanced gastric carcinoma[J].Suppl Tumori,2005; 4(3)∶S88. |
| 10. | Newman E,Marcus SG,Potmesil M,et al.Neoadjuvant ch-emotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer[J].J Gastrointest Surg,2002; 6(2)∶212. |
| 11. | Lowy AM,Mansfield PF,Leach SD,et al.Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer[J].Ann Surg,1999; 229(3)∶303. |
| 12. | Koizumi W,Kurihara M,Nakano S,et al.Phase Ⅱ study of S-1,a novel oral derivative of 5-fluorouracil,in advanced gastric cancer.For the S-1 Cooperative Gastric Cancer Study Group[J].Oncology,2000; 58(3)∶191. |
| 13. | Nakano K,Koizumi H,Okugawa K,et al.Evaluation of pre-operative administration of TS-1 in patients with advanced gastric or colorectal cancer--estimation of pathological effectiveness for postoperative adjuvant chemotherapy with TS-1[J].Gan To Kagaku Ryoho,2005; 32(3)∶329. |
| 14. | Yoshida K,Ishikawa H,Sumida Y,et al.A case of N3 gastric cancer successfully treated by TS-1 followed by curative resection[J].Gan To Kagaku Ryoho,2006; 33(9)∶1321. |
| 15. | Tsuchiya Y,Nashimoto A,Nakagawa S,et al.Advanced gastric cancer responding to pathological CR after neoadjuvant TS-1 combined with CDDP therapy--report of a case[J].Gan To Kagaku Ryoho,2006; 33(6)∶807. |
| 16. | Nomura M,Inoue Y,Fujita S,et al.A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy[J].Gan To Kagaku Ryoho,2006; 33(1)∶99. |
| 17. | Mori S,Kishimoto H,Tauchi K,et al.Histological complete response in advanced gastric cancer after 2 weeks of S-1 administration as neoadjuvant chemotherapy[J].Gastric Cancer,2006; 9(2)∶136. |
| 18. | Willett CG.Results of radiation therapy in gastric cancer[J].Semin Radiat Oncol,2002; 12(2)∶170. |
| 19. | Klautke G,Foitzik T,Ludwig K,et al.Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma[J].Strahlenther Onkol,2004; 180(11)∶695. |
| 20. | Ajani JA,Mansfield PF,Janjan N,et al.Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma[J].J Clin Oncol,2004; 22(14)∶2774. |
| 21. | Mauera M,Harafd C,Ferguson K,et al.Docetaxel-based combined modality therapy for locally advance carcinoma of the esophagus and gastric carcinoma[J].Proc Am Soc Clin Oncol,2000; 19(6)∶954. |
| 22. | Roth AD,Allal AS,Brundler MA,et al.Neoadjuvant radiochemotherapy for locally advanced gastric cancer:a phase Ⅰ-Ⅱ study[J].Ann Oncol,2003; 14(1)∶110. |
| 23. | Lowy AM,Feig BW,Janjan N,et al.A pilot study of preoperative chemoradiotherapy for resectable gastric cancer[J].Ann Surg Oncol,2001; 8(6)∶519. |
| 24. | Shchepotin IB,Chorny V,Hanfelt J,et al.Palliative superselective intra-arterial chemotherapy for advanced nonresectable gastric cancer[J].J Gastrointest Surg,1999; 3(4)∶426. |
| 25. | 吳鵬,朱正綱,葉正寶,等.5-氟尿嘧啶-2′-脫氧核苷經胃左動脈介入灌注后的藥代動力學實驗研究[J].外科理論與實踐,2004; 9(2)∶135. |
| 26. | 蒲青凡,孫碎康,劉占培,等.術前胃動脈化療栓塞對胃癌淋巴結轉移灶癌細胞凋亡的影響[J].中國普外基礎與臨床雜志,2006; 13(4)∶427. |
| 27. | 王舒寶,王俊.胃癌復發與轉移的有關問題及綜合治療[J].中國普外基礎與臨床雜志,2006; 13(1)∶9. |
| 28. | 孫建軍,馬建芳,陳少華.動脈灌注化療聯合栓塞治療晚期胃癌[J].江西醫學院學報,2006; 46(4)∶138. |
| 29. | 時桂蘭,邢海鳳,劉文昌,等.胃癌術前介入治療的臨床意義[J].現代醫用影像學,2005; 14(4)∶165. |
| 30. | Pestieau SR,Sugarbaker PH.Treatment of primary colon cancer with peritoneal carcinomatosis:comparison of concomitant vs.delayed management[J].Dis Colon Rectum,2000; 43(10)∶1341. |
| 31. | Brenner B,Shah MA,Karpeh MS,et al.A phase Ⅱ trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer[J].Ann Oncol,2006; 17(9)∶1404. |
| 32. | Ceelen WP,Hesse U,de Hemptinne B,et al.Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer[J].Br J Surg,2000; 87(8)∶1006. |
| 33. | Pestieau SR,Schnake KJ,Stuart OA,et al.Impact of carrier solutions on pharmacokinetics of intraperitoneal chemotherapy[J].Cancer Chemother Pharmacol,2001; 47(3)∶269. |
| 34. | Jansen M,Büchin P,Dreuw B,et al.Prognostic factors for development of peritoneal carcinosis in stomach carcinoma[J].Chirurgeon,2001; 72(5)∶561. |
| 35. | Newman E,Potmesil M,Ryan T,et al.Neoadjuvant chemotherapy,surgery,and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma:a phase Ⅱ study[J].Semin Oncol,2005; 32(6 Suppl 9)∶S97. |
| 36. | 梁寒,王仆,王曉娜,等.活性碳吸附絲裂霉素C腹腔化療預防進展期胃癌術后復發[J].中華外科雜志,2003; 41(4)∶274. |
| 37. | 李琛.腹腔溫熱化療的臨床意義及其對機體生理功能的影響[J].外科理論與實踐,1998; 3(1)∶48. |
| 38. | Roviello F,Marrelli D,Neri A,et al.Treatment of peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP):postoperative outcome and risk factors for morbidity[J].World J Surg,2006; 30(11)∶2033. |
| 39. | Marutsuka T,Shimada S,Shiomori K,et al.Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma:an ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis[J].Clin Cancer Res,2003; 9(2)∶678. |
| 40. | 何濤,楊志明,伍曉汀.胃癌腹膜播散轉移機理的研究進展[J].中國普外基礎與臨床雜志,2005; 12(1)∶45. |
| 41. | De Roover A,Detroz B,Detry O,et al.Adjuvant hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) associated with curative surgery for locally advanced gastric carcinoma.An initial experience[J].Acta Chir Belg,2006; 106(3)∶297. |
| 42. | Yonemura Y,de Aretxabala X,Fujimura T,et al.Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer:final results of a randomized controlled study[J].Hepatogastroenterology,2001; 48(42)∶1776. |
| 43. | 朱正綱,湯睿.術中腹腔內溫熱化療對進展期胃癌的臨床療效研究[J].中華胃腸外科雜志,2006; 9(1)∶26. |
| 44. | Janunger KG,Hafstrom L,Glimelius B.Chemotherapy in gastric cancer:a review and updated meta-analysis[J].Eur J Surg,2002; 168(11)∶597. |
| 45. | Valentini V,Cellini F,D’Angelillo RM.Combined treatments in gastric cancer:radiotherapy[J].Suppl Tumori,2003; 2(5)∶S39. |
| 46. | 季加孚主編.胃癌防治新觀念[M].北京:人民軍醫出版社,2007∶1～4. |
| 47. | Cunliffe WJ,Sugarbaker PH.Gastrointestinal malignancy:rationale for adjuvant therapy using early postoperative intraperitoneal chemotherapy[J].Br J Surg,1989; 76(10)∶1082. |
| 48. | van Ruth S,Verwaal VJ,Hart AA,et al.Heat penetration in locally applied hyperthermia in the abdomen during intra-operative hyperthermic intraperitoneal chemotherapy[J].Anticancer Res,2003; 23(2B)∶1501. |
- 1. <>[1]Higuchi K,Phan A,Ajani JA.Gastric cancer:advances in adjuvant and adjunct therapy[J].Curr Treat Options Oncol,2003; 4(5)∶413.
- 2. 劉福坤,姚學權.胃癌的新輔助化療[J].中國普外基礎與臨床雜志,2006; 13(1)∶18.
- 3. Cheong JH,Shen JY,Song CS,et al.Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer[J].Ann Surg Oncol,2007; 14(1)∶61.
- 4. 詹文華.胃癌手術前化療的研究現狀[J].中華胃腸外科雜志,2005; 8(5)∶471.
- 5. Frei E 3rd.Clinical cancer research:an embattled species[J].Cancer,1982; 50(10)∶1979.
- 6. Cunningham D,Allum WH,Stenning SP,et al.Perioperative chemotherapy in operable gastric and lower oesophageal cancer:final results of a randomized controlled trial (the MAGIC trial,ISRCTN 93793971)[J].Proc Am Soc Clin Oncol,2005; 23∶308s.
- 7. Wilke H,Preusser P,Fink U,et al.Preoperative chemotherapy in locally advanced and nonresectable gastric cancer:a phase Ⅱ study with etoposide,doxorubicin,and cisplatin[J].J Clin Oncol,1989; 7(9)∶1318.
- 8. Yamaguchi K,Nakagawa S,Yabusaki H,et al.A case of advanced gastric cancer responding remarkably to paclitaxel + low-dose FP therapy in a neoadjuvant setting[J].Gan To Kagaku Ryoho,2006; 33(8)∶1163.
- 9. Persiani R,D’Ugo D,Biondi A,et al.T-downstaging after neoadjuvant chemotherapy in locally advanced gastric carcinoma[J].Suppl Tumori,2005; 4(3)∶S88.
- 10. Newman E,Marcus SG,Potmesil M,et al.Neoadjuvant ch-emotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer[J].J Gastrointest Surg,2002; 6(2)∶212.
- 11. Lowy AM,Mansfield PF,Leach SD,et al.Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer[J].Ann Surg,1999; 229(3)∶303.
- 12. Koizumi W,Kurihara M,Nakano S,et al.Phase Ⅱ study of S-1,a novel oral derivative of 5-fluorouracil,in advanced gastric cancer.For the S-1 Cooperative Gastric Cancer Study Group[J].Oncology,2000; 58(3)∶191.
- 13. Nakano K,Koizumi H,Okugawa K,et al.Evaluation of pre-operative administration of TS-1 in patients with advanced gastric or colorectal cancer--estimation of pathological effectiveness for postoperative adjuvant chemotherapy with TS-1[J].Gan To Kagaku Ryoho,2005; 32(3)∶329.
- 14. Yoshida K,Ishikawa H,Sumida Y,et al.A case of N3 gastric cancer successfully treated by TS-1 followed by curative resection[J].Gan To Kagaku Ryoho,2006; 33(9)∶1321.
- 15. Tsuchiya Y,Nashimoto A,Nakagawa S,et al.Advanced gastric cancer responding to pathological CR after neoadjuvant TS-1 combined with CDDP therapy--report of a case[J].Gan To Kagaku Ryoho,2006; 33(6)∶807.
- 16. Nomura M,Inoue Y,Fujita S,et al.A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy[J].Gan To Kagaku Ryoho,2006; 33(1)∶99.
- 17. Mori S,Kishimoto H,Tauchi K,et al.Histological complete response in advanced gastric cancer after 2 weeks of S-1 administration as neoadjuvant chemotherapy[J].Gastric Cancer,2006; 9(2)∶136.
- 18. Willett CG.Results of radiation therapy in gastric cancer[J].Semin Radiat Oncol,2002; 12(2)∶170.
- 19. Klautke G,Foitzik T,Ludwig K,et al.Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma[J].Strahlenther Onkol,2004; 180(11)∶695.
- 20. Ajani JA,Mansfield PF,Janjan N,et al.Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma[J].J Clin Oncol,2004; 22(14)∶2774.
- 21. Mauera M,Harafd C,Ferguson K,et al.Docetaxel-based combined modality therapy for locally advance carcinoma of the esophagus and gastric carcinoma[J].Proc Am Soc Clin Oncol,2000; 19(6)∶954.
- 22. Roth AD,Allal AS,Brundler MA,et al.Neoadjuvant radiochemotherapy for locally advanced gastric cancer:a phase Ⅰ-Ⅱ study[J].Ann Oncol,2003; 14(1)∶110.
- 23. Lowy AM,Feig BW,Janjan N,et al.A pilot study of preoperative chemoradiotherapy for resectable gastric cancer[J].Ann Surg Oncol,2001; 8(6)∶519.
- 24. Shchepotin IB,Chorny V,Hanfelt J,et al.Palliative superselective intra-arterial chemotherapy for advanced nonresectable gastric cancer[J].J Gastrointest Surg,1999; 3(4)∶426.
- 25. 吳鵬,朱正綱,葉正寶,等.5-氟尿嘧啶-2′-脫氧核苷經胃左動脈介入灌注后的藥代動力學實驗研究[J].外科理論與實踐,2004; 9(2)∶135.
- 26. 蒲青凡,孫碎康,劉占培,等.術前胃動脈化療栓塞對胃癌淋巴結轉移灶癌細胞凋亡的影響[J].中國普外基礎與臨床雜志,2006; 13(4)∶427.
- 27. 王舒寶,王俊.胃癌復發與轉移的有關問題及綜合治療[J].中國普外基礎與臨床雜志,2006; 13(1)∶9.
- 28. 孫建軍,馬建芳,陳少華.動脈灌注化療聯合栓塞治療晚期胃癌[J].江西醫學院學報,2006; 46(4)∶138.
- 29. 時桂蘭,邢海鳳,劉文昌,等.胃癌術前介入治療的臨床意義[J].現代醫用影像學,2005; 14(4)∶165.
- 30. Pestieau SR,Sugarbaker PH.Treatment of primary colon cancer with peritoneal carcinomatosis:comparison of concomitant vs.delayed management[J].Dis Colon Rectum,2000; 43(10)∶1341.
- 31. Brenner B,Shah MA,Karpeh MS,et al.A phase Ⅱ trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer[J].Ann Oncol,2006; 17(9)∶1404.
- 32. Ceelen WP,Hesse U,de Hemptinne B,et al.Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer[J].Br J Surg,2000; 87(8)∶1006.
- 33. Pestieau SR,Schnake KJ,Stuart OA,et al.Impact of carrier solutions on pharmacokinetics of intraperitoneal chemotherapy[J].Cancer Chemother Pharmacol,2001; 47(3)∶269.
- 34. Jansen M,Büchin P,Dreuw B,et al.Prognostic factors for development of peritoneal carcinosis in stomach carcinoma[J].Chirurgeon,2001; 72(5)∶561.
- 35. Newman E,Potmesil M,Ryan T,et al.Neoadjuvant chemotherapy,surgery,and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma:a phase Ⅱ study[J].Semin Oncol,2005; 32(6 Suppl 9)∶S97.
- 36. 梁寒,王仆,王曉娜,等.活性碳吸附絲裂霉素C腹腔化療預防進展期胃癌術后復發[J].中華外科雜志,2003; 41(4)∶274.
- 37. 李琛.腹腔溫熱化療的臨床意義及其對機體生理功能的影響[J].外科理論與實踐,1998; 3(1)∶48.
- 38. Roviello F,Marrelli D,Neri A,et al.Treatment of peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP):postoperative outcome and risk factors for morbidity[J].World J Surg,2006; 30(11)∶2033.
- 39. Marutsuka T,Shimada S,Shiomori K,et al.Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma:an ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis[J].Clin Cancer Res,2003; 9(2)∶678.
- 40. 何濤,楊志明,伍曉汀.胃癌腹膜播散轉移機理的研究進展[J].中國普外基礎與臨床雜志,2005; 12(1)∶45.
- 41. De Roover A,Detroz B,Detry O,et al.Adjuvant hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) associated with curative surgery for locally advanced gastric carcinoma.An initial experience[J].Acta Chir Belg,2006; 106(3)∶297.
- 42. Yonemura Y,de Aretxabala X,Fujimura T,et al.Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer:final results of a randomized controlled study[J].Hepatogastroenterology,2001; 48(42)∶1776.
- 43. 朱正綱,湯睿.術中腹腔內溫熱化療對進展期胃癌的臨床療效研究[J].中華胃腸外科雜志,2006; 9(1)∶26.
- 44. Janunger KG,Hafstrom L,Glimelius B.Chemotherapy in gastric cancer:a review and updated meta-analysis[J].Eur J Surg,2002; 168(11)∶597.
- 45. Valentini V,Cellini F,D’Angelillo RM.Combined treatments in gastric cancer:radiotherapy[J].Suppl Tumori,2003; 2(5)∶S39.
- 46. 季加孚主編.胃癌防治新觀念[M].北京:人民軍醫出版社,2007∶1～4.
- 47. Cunliffe WJ,Sugarbaker PH.Gastrointestinal malignancy:rationale for adjuvant therapy using early postoperative intraperitoneal chemotherapy[J].Br J Surg,1989; 76(10)∶1082.
- 48. van Ruth S,Verwaal VJ,Hart AA,et al.Heat penetration in locally applied hyperthermia in the abdomen during intra-operative hyperthermic intraperitoneal chemotherapy[J].Anticancer Res,2003; 23(2B)∶1501.